Effect of acupuncture on arthritic pathological injury in rats with type Ⅱ collagen-induced rheumatoid arthritis.

Objectives: To observe the effect of acupuncture stimulation of "Yanglingquan"(GB34), "Zusanli"(ST36) and "Xuanzhong" (GB39) on arthritis index (AI), joint synovial membrane pathology, serum-related immunoinflammatory factors, and expressions of tumor suppressor gene mt-p53, nuclear factor kappa B (NF-κB) and peroxisome proliferator activated receptor gamma (PPARγ) in knee joint synovial tissue of rats with type Ⅱ collagen-induced arthritis (CIA), so as to explore its possible mechanisms underlying improvement of rheumatoid arthritis (RA).

Methods: Male SD rats were used in the present study. The CIA model was established by subcutaneous injection of collagen emulsion (200 μL/rat) in the tail root region on the first day and repeat (100 μL/rat) once on the 9 day.

Effects of Zishen Yutai Pills on in vitro Fertilization-Embryo Transfer Outcomes in Patients with Diminished Ovarian Reserve: A Prospective, Open-Labeled, Randomized and Controlled Study.

Objective: To explore the effects of Zishen Yutai Pills (ZYPs) on the quality of oocytes and embryos, as well as pregnancy outcomes in patients with diminished ovarian reserve (DOR) receiving in vitro fertilization-embryo transfer (IVF-ET). The possible mechanisms, involving the regulation of bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), were also investigated.

Methods: A total of 120 patients with DOR who underwent their IVF-ET cycle were randomly allocated to 2 groups in a 1:1 ratio.

Design, synthesis and biological characteristics of pyrazolo[3,4-]pyrimidine derivatives as potential VEGFR-2 inhibitors.

Several VEGFR-2 inhibitors with the structure of [3,4-d]pyrimidine and based on sorafenib were designed and synthesized. Cytotoxic activity was evaluated by MTT, wound healing and clone formation assays. Cell cycle and apoptosis were analyzed by flow cytometry.

The Role of Traditional Chinese Formula Ding-Kun Pill (DKP) in Expected Poor Ovarian Response Women (POSEIDON Group 4) Undergoing Fertilization-Embryo Transfer: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.

Objective: The primary objective of the study was to assess traditional Chinese formula DKP supplementation in terms of efficacy and safety on reproductive outcomes of expected poor ovarian responder (POR, POSEIDON Group 4) undergoing fertilization-embryo transfer (IVF-ET).

Design Setting And Participants: Women eligible for IVF-ET were invited to participate in this randomized, double-blind, placebo-controlled, superiority trial at academic fertility centers of ten public hospitals in Chinese Mainland. A total of 462 patients (35-44 years) equally divided between DKP and placebo groups with antral follicle count (AFC) <5 or anti-müllerian hormone (AMH) <1.

Monoclonal Antibodies, Small Molecule Inhibitors and Antibody-drug Conjugates as HER2 Inhibitors.

Overexpression of human epidermal growth factor receptor (HER)-2 is found in a variety of cancers, often portending poor clinical outcomes. Therefore, HER2 is an attractive target for treatment. This review describes the research progress of HER2 targeted inhibitors in recent years.

[GG Genotype at rs1275988 and rs2586886 Loci of TWIK-related Acid-sensitive K Channel-1 Gene is A Potential Risk Factor for Severe Obstructive Sleep Apnea].

To explore the mechanism of obstructive sleep apnea(OSA) by assessing the association between human TWIK-related acid-sensitive K channel-1(TASK-1) gene and OSA. A total of 164 patients with severe OSA and 171 patients without OSA were recruited from the Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region,China,from April to December 2016.Two single nucleotide polymorphisms(rs1275988 and rs2586886) in the TASK-1 gene were selected and genotyped using a Kompetitive Allele Specific PCR genotyping system.

Genetic variants of rs1275988 and rs2586886 in TWIK-related acid-sensitive K+ channel-1 gene may be potential risk factors for obese patients with obstructive sleep apnea.

Background: The pathogenesis of obstructive sleep apnea (OSA) remains not fully understood. This study aimed to explore the mechanism of OSA by assessing the association between the human tandem of P domains in a weak inwardly rectifying K channel (TWIK)-related acid-sensitive K channel-1 (TASK-1) gene and OSA.

Methods: A total of 164 patients with severe OSA and 171 patients without OSA were recruited from the Center for Hypertension of People's Hospital of Xinjiang Uygur Autonomous Region (China) from April to December in 2016.

Preventive treatment of astaxanthin provides neuroprotection through suppression of reactive oxygen species and activation of antioxidant defense pathway after stroke in rats.

Astaxanthin, a natural antioxidant carotenoid, has been shown to reduce cerebral ischemic injury in rodents. However, there have not been any studies specifically addressing whether preventive administration of astaxanthin can protect against cerebral ischemia. The purpose of this study was to examine whether pretreatment of astaxanthin can protect against ischemic injuries in the adult rats.

[Factors affecting the success rate of artificial insemination with donor sperm].

Objective: To explore various factors affecting the clinical pregnancy outcomes of artificial insemination with donor sperm (AID).

Methods: We retrospectively analyzed 15,744 cycles of AID in 6302 women and investigated the association of the clinical pregnancy outcomes of AID with the treatment protocols, the times of insemination per cycle, the age of the infertile women, the status of the oviduct, and the number of AID cycles.

Results: The pregnancy rate of AID was higher in the chlomiphene-treated women than in those of the natural cycle group (P = 0.

Comparison of hypoglycemic and antioxidative effects of polysaccharides from four different Dendrobium species.

Four polysaccharides from Dendrobium huoshanense (DHP), D. officinale (DOP), D. nobile (DNP) and D.

[Effects of plasma from patients with preeclampsia on the proliferation and apoptosis of human umbilical vein endothelial cells and its relationship with lysophosphatidic acid receptors].

Objectives: To investigate the effects of plasma from the patients with preeclampsia on proliferation and apoptosis of human umbilical vein endothelial cells (HUVEC), and to explore the relationship between cell damage and lysophosphatidic acid (LPA) receptors.

Methods: Sixty patients with preeclampsia were recruited from October 2011 to June 2012 in the First Affiliated Hospital of Zhengzhou University. Among them, thirty cases were defined as the mild preeclampsia group and thirty cases were defined as the severe preeclampsia group.

[Behavioral characteristics of men who have sex with men with sadomasochism associated with bleeding].

Objective: To investigate the behavioral characteristics of men who have sex with men (MSM)with sadomasochism associated bleeding and to analyze the relationship with HIV/AIDS high risk behavior.

Methods: Using modified snowball sampling methods (target sampling methods) to carry out a cross-sectional study on persons with behavior of sadomasochism that associated with bleeding in MSM, using a valid questionnaire. Another control group without the related behavior was set up.

[Study on the AIDS-related high risk behaviors of men who have sex with men under the experience of exchanging money for the same sex].

Objective: To investigate the AIDS-related high risk behaviors of men who have sex with men (MSM) who ever exchanged money for the same sex.

Methods: Target sampling for cross-sectional study and valid anonymous questionnaires were adopted to compare the differences of AIDS-related high risk behaviors between MSM with the experience of exchanging money for the same sex and those without that experience. 1959 rstadied samples were recruited in nine cities.

[Study on the association of partner-seeking and high risk behaviors related to AIDS among men who have sex with men in the different sites].

Objective: To explore the situation of AIDS-related high risk behaviors among men who have sex with men (MSM) ever experienced partner-seeking in different sites.

Methods: Target sampling for cross-sectional study ("snowball") and valid anonymous questionnaires were adopted to compare the differences of high risk behaviors related to AIDS. 1834 MSM were studied in nine cities who sought sex partners through internet, bars or bath ponds.

[Study on the high risk behaviors related to AIDS among men who having sex with men in the floating population].

Objective: To explore the risks on sexual behaviors related to AIDS among men who having sex with men (MSM) in floating population and to develop relevant interventions.

Methods: Study objectives were recruited through target sampling and anonymous questionnaires were adopted. Male sexual behaviors were compared between floating population and permanent registered residents.

[Study on HIV/AIDS related high risk behaviors among unmarried men who have sex with women].

Objective: To explore the risk of sexual behaviors related to AIDS among unmarried men who often have sex with women.

Methods: Study objectives were recruited through target sampling and anonymous questionnaires were adopted. Men' s sexual behaviors were compared with each other between the group of men who always had sex with women (group A) and who never had sex with women (group B) in the past 6 months.

[Associations between partner-seeking activities through Internet and sexual risk behaviours related to HIV/AIDS among men who have sex with men in China].

Objective: To explore the associations between partner-seeking activities through internet and HIV/AIDS related risk behaviours among men who have sex with men (MSM).

Methods: Target sampling, anonymous questionnaires were adopted and analyzed with SPSS 11.0.

[Study on the comparison of high risk behaviors related to AIDS among different status of income in men who have had sex with men].

Objective: To explore the risk sexual behaviors related to AIDS among different status of income among men who have had sex with men and to provide relevant interventions for AIDS control and prevention.

Methods: Study objectives were recruited through target sampling and anonymous questionnaires were adopted. Men's sexual behaviors were reported under the categories as high, mid or low-income.