Phase I clinical trial designs in oncology: A systematic literature review from 2020 to 2022.

Background: Phase I clinical trials aim to find the highest dose of a novel drug that may be administrated safely without having serious adverse effects. Model-based designs have recently become popular in dose-finding procedures. Our objective is to provide an overview of phase I clinical trials in oncology.

Light responsive Fe-Tcpp@ICG for hydrogen peroxide detection and inhibition of tumor cell growth.

In this work, we synthesized Fe-Tcpp@ICG(ICG, Indocyanine green) with light stimuli-response through 5,10,15,20-tetrakis (4-carboxyphenyl) porphyrin (Fe-Tcpp) loaded ICG by electrostatic adsorption. The morphology and properties of Fe-Tcpp and Fe-Tcpp@ICG were characterised by ultraviolet-visible absorption spectrometer, X-ray diffraction, thermogravimetric analyzer and transmission electron microscope, respectively. A non-enzymatic photoelectrochemical sensor based on Fe-Tcpp@ICG was constructed to quantitatively detect hydrogen peroxide in tumor microenvironment.

Suppression Attack Against Multicast Protocol in Low Power and Lossy Networks: Analysis and Defenses.

With increasingly prevalent wireless sensors and devices, low power and lossy networks (LLNs) play an essential role in the realization of ubiquitous computing and communication infrastructure, which, in turn, leads to enhanced data accessibility and availability. A multicast protocol for LLNs (MPL), has been standardized to provide both efficient and reliable multicast communication. Due to the shared wireless medium, lack of tamper resistance, and inherent resource constraints, MPL-based LLNs are undoubtedly vulnerable to various Denial-of-Service (DoS) attacks.