A Mannosylated peptidyl lipid CManDA doped into cytidinyl/cationic lipids efficiently delivers siG12Ss to lung cancer in vivo.

Gene therapy has attracted widespread attention in recent years, and one of the important delivery systems is the LNP. However, many LNPs have potential toxicity and accumulate in the liver. Here, we designed and synthesized a Gemini-type mannosylated peptidyl lipid called CManDA(M), which, in combination with the cytidinyl lipid DNCA(D) and the peptidyl lipid CLD(C) (D/50C/50 M), could transfect siRNA (siG12S) into A549 cells to target and silence the KRAS gene.

Caveolin-1 protects against liver injury and lipid accumulation in alcoholic fatty liver via ferroptosis resistance.

Alcoholic fatty liver (AFL) is one of the most common chronic liver diseases globally with complex and controversial pathogenesis. Recent evidence suggests that iron overload and lipid peroxidation are risk factors for AFL. Caveolin-1 (CAV1) is an important signal platform that can maintain lipid homeostasis during the development of non-alcoholic fatty liver.

Effect of Diethanolamine after Carbon Dioxide Absorption and Desorption on Mechanical Strength of Cement Mortar and Mechanism.

Diethanolamine (DEA) can be used not only as a cement admixture but also to capture carbon dioxide (CO). However, the waste liquid treatment still faces the problems of high energy consumption and increasing environmental burden. The effects of DEA waste liquid (WL-DEA) with multiple cycles of CO absorption and desorption on the setting time, hydration temperature, mechanical strength, and microstructure of cement-based materials were explored.

Study on Vacuum Breakdown Properties of Surface-Modified 304 Stainless Steel Electrodes Based on Fractal Theory.

This paper reports on the effect of the micro-morphological characteristics of stainless steel electrodes on vacuum breakdown properties under the action of a strong electric field generated by high-power electric pulses. Using chemical passivation modification and atomic layer deposition (ALD) technology, alumina composite films were prepared on the surface of the stainless steel electrodes to reshape the surface microstructure of the electrodes. The surface morphology features of the electrodes were characterized in detail.

Molecular Dynamics Simulation Study on the Influence of Twin Spacing and Temperature on the Deformation Behavior of Nanotwinned AgPd Alloy.

This study employs molecular dynamics simulations to unravel the interplay between twin spacing, temperature, and mechanical response in nanotwinned AgPd alloys. For fine-grained systems, a dual strengthening-softening transition emerges as twin spacing decreases, driven by a shift in dislocation behavior from inclined-to-twin-boundary slip to parallel-to-twin-boundary glide. In contrast, coarse-grained configurations exhibit monotonic strengthening with reduced twin spacing, governed by strain localization at grain boundaries and suppressed dislocation activity.

Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma.

Objective: Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma (MCL) than those in Western. Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas, we designed a prospective, phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL. The primary endpoint was the complete remission rate (CRR) at the end of induction (EOI).

A PEGylated conjugated-BODIPY oligomer for NIR-II imaging-guided photothermal therapy.

The integration of second near-infrared (NIR-II) fluorescence imaging and photothermal therapy (PTT) achieved precise and efficient tumor treatment. BODIPY, a promising fluorescent dye, is widely used in biological fluorescence imaging due to its excellent optical properties and chemical stability. However, the excitation wavelengths of BODIPY typically range from 530 nm to 650 nm within the visible spectrum, which significantly limits tissue penetration.

Application of Near-Infrared Spectroscopy in Early Detection of Antidepressant Treatment Efficacy in Major Depressive Disorder: A Longitudinal Study.

Background: Major depressive disorder (MDD) is a prevalent and debilitating mental health condition, necessitating early detection and effective treatment strategies. Near-infrared spectroscopy (NIRS) is a promising neuroimaging technique for monitoring cerebral hemodynamics and may serve as an objective biomarker for MDD diagnosis and treatment efficacy. This study aimed to investigate the utility of NIRS in the early detection and longitudinal monitoring of antidepressant treatment efficacy in MDD patients.

Leveraging Large Language Models for Predicting Postoperative Acute Kidney Injury in Elderly Patients.

The objective of this work is to develop a framework based on large language models (LLMs) to predict postoperative acute kidney injury (AKI) outcomes in elderly patients. Our study demonstrates that LLMs have the potential to address the issues of poor generalization and weak interpretability commonly encountered in disease prediction using traditional machine learning (ML) models. AKI is a severe postoperative complication, especially in elderly patients with declining renal function.

Integrated multi-biomarker panel of CXCL13, HS-CRP, and WBC counts predicts outcomes in stroke neurosyphilis patients treated with HBO and TUS-NMES.

Background: Neurosyphilis results from invading the central nervous system, leading to severe neurological issues like stroke. Combining hyperbaric oxygen (HBO) therapy and transcranial ultrasound neuromuscular stimulation (TUS-NMES) shows promise in improving outcomes.

Objective: This study evaluates the predictive value and clinical significance of CXCL13, WBC, and Hs-CRP levels in neurosyphilis patients undergoing HBO and TUS-NMES therapy.

Stabilizing Ru in Multicomponent Alloy as Acidic Oxygen Evolution Catalysts with Machine Learning-Enabled Structural Insights and Screening.

Developing active, stable, and cost-effective acidic oxygen evolution reaction (OER) catalyst is a critical challenge in realizing large-scale hydrogen (H) production via electrochemical water splitting. Utilizing highly active and relatively inexpensive Ru is generally challenged by its long-term durability issue. Here, we explore the potential of stabilizing active Ru sites in Ru(Ir,Fe,Co,Ni) multicomponent alloy by investigating its phase formation behavior, OER performance, and OER-induced surface reconstruction.

CNV-mediated dysregulation of the ceRNA network mechanism revealed heterogeneity in diffuse and intestinal gastric cancers.

Background: Gastric cancer (GC) is a highly heterogeneous tumour with high morbidity. Approximately 95% of GC cases are gastric adenocarcinomas, which are further categorized into two predominant subtypes: diffuse gastric cancer (DGC) and intestinal gastric cancer (IGC). These subtypes exhibit distinct pathophysiological and molecular characteristics, reflecting their unique tumorigenic mechanisms.

Mortality rate and risk factors for relaparotomy after caesarean section: a systematic review and meta-analysis.

Background: The high prevalence of caesarean section (CS) is a global concern. Relaparotomy is needed when conservative managements are not effective in CS complications. This study aimed to systematically review and meta-analyze the mortality rate and risk factors of relaparotomy after CS.

Confronting cultures: northern Madagascar's cultural beliefs and the relationship of owls and humans.

Owls are often associated with superstitions and witchcraft in various cultures, leading to conflicts between human communities and these birds. This study, conducted in 2023 across 16 villages in Andapa, a northern district of Madagascar, aimed to investigate the challenges of human-owl coexistence. It specifically explored the cultural beliefs and conflicts driving the motivation to kill owls, particularly during witch-hunting incidents between 2021 and 2022.

Association between Geriatric Nutritional Risk Index and all-cause mortality in individuals with osteoporotic fractures: a retrospective cohort study.

Background: The number of patients with osteoporotic fractures (OPFs) is on the rise because of global aging. However, few studies have examined the connection between Geriatric Nutritional Risk Index (GNRI) and overall mortality among inpatients with OPFs. Thus, our research seeks to investigate the link between GNRI and overall mortality in inpatients with OPFs.

CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling.

SARS-CoV-2 can encode circular RNAs (circRNAs); however, the potential effects of exogenous SARS-CoV-2 circRNAs on cardiovascular sequelae remain unknown. Three circRNAs derived from the nucleocapsid (N) gene of SARS-CoV-2, namely, circSARS-CV2-Ns, were identified for functional studies. In particular, circSARS-CV2-N1368 was shown to enhance platelet adhesiveness to endothelial cells (ECs) and inhibit EC-dependent vascular relaxation.

Irreversible electroporation combined with PD-L1/IL-6 dual blockade promotes anti-tumor immunity via cDC2/CD4T cell axis in MHC-I deficient pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) is a "cold" solid tumor with frequent Major Histocompatibility Complex I (MHC-I) deficiency, thereby making it resistant to type-1-conventional dendritic cell (cDC1)-CD8T cell mediated anti-tumor immunity. Current studies have demonstrated the emerging compensatory role of MHC-II-mediated antigen presentation and CD4T cell activation in anti-tumor immunity against MHC-I-deficient tumors. However, the underlying mechanism of the compensatory immune response by CD4T cells in cancer ablation therapy remains to be elucidate.

Dendritic donor engineering to optimize second near-infrared photothermal agents for in situ photothermal therapy.

Small organic photothermal agents (PTAs) with dual photothermal and imaging functions in the second near-infrared (NIR-II) window present a promising strategy for deep tumor treatment, however, fluorescence quenching conventional PTAs and low photothermal conversion efficiency (PCE) present obstacles to their widespread application. In this study, a novel "dendritic donor engineering" strategy was employed to design NIR-II organic PTAs (named DCTBBT and TCTBBT) with donor-π-acceptor-π-donor features and aggregation-induced emission (AIE) activity. Owing to the fine-tuning of the dendritic donors, the close co-facial packing of the central π-backbone was disrupted, effectively avoiding fluorescence quenching caused by π-π aggregation, which facilitated molecule-free motions in aggregate state, and as a result, the DCTBBT nanoparticles (NPs) demonstrated a PCE of 59.

Revisiting the Origins of Reactivity and Selectivity in the PdL-Cage-Catalyzed Diels-Alder Reactions: A Combined Computational and Experimental Study.

Supramolecular metal-organic cages (MOCs) have gained attention as versatile catalytic platforms due to their self-assembled architectures and well-defined cavities, which mimic enzyme active sites and enable spatial confinement. This confinement modulates the reaction pathways and enhances the catalytic performance. Recent studies highlight their catalytic potential in various organic transformations, but the factors governing the MOC-catalyzed reactions remain incompletely understood.

UW-DNeRF: Deformable Soft Tissue Reconstruction with Uncertainty-Guided Depth Supervision and Local Information Integration.

Reconstructing deformable soft tissues from endoscopic videos is a critical yet challenging task. Leveraging depth priors, deformable implicit neural representations have seen significant advancements in this field. However, depth priors from pre-trained depth estimation models are often coarse, and inaccurate depth supervision can severely impair the performance of these neural networks.

Cardiac MRI optimizes risk stratification accuracy in connective tissue disease-associated pulmonary arterial hypertension: a retrospective cohort study.

Objectives: The primary objective of this study is to investigate the potential of cardiovascular magnetic resonance (CMR) parameters to augment prognostic evaluation in patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH).

Methods: A retrospective, single-center cohort study was conducted on 110 patients with CTD-PAH who were diagnosed via right heart catheterization between 2017 and 2023. These patients underwent CMR examinations based on clinical indications.

Vertically Phase-Separated PEDOT:PSS Film via Solid-Liquid Interface Doping for Flexible Organic Electrochemical Transistors.

Organic electrochemical transistors (OECTs) are seen as some of the most promising devices in organic bioelectronics. Recent interest in OECTs is sparked by the high performance of an organic semiconductor channel material, i.e.

Impact of parathyroid gland classification on hypoparathyroidism following total thyroidectomy with central neck dissection for differentiated thyroid cancer.

Objective: To assess the impact of parathyroid gland (PG) classification on hypoparathyroidism incidence following total thyroidectomy (TT) with central neck dissection (CND) in patients with differentiated thyroid carcinoma (DTC).

Methods: In this prospective cohort study, adult patients with DTC who underwent TT with CND between 2021 and 2023 were enrolled, with a maximum follow-up duration of 32 months. A simplified PG classification system was employed, categorizing glands into four distinct types: tightly connected, loosely connected, non-connected, and thymic.

Efficacy and safety of non-ablative vs. ablative lasers for acne scarring: A meta-analysis.

Acne scarring significantly affects physical appearance and psychological well-being, prompting the exploration of various treatment options, including ablative and non-ablative laser therapies. The debate around their efficacy and safety persists, underscoring the need for a comprehensive analysis. This meta-analysis compares the therapeutic outcomes and safety profiles of ablative and non-ablative laser treatments for acne scars, based on a comprehensive review of clinical trials conducted up to March 2023.