Macrocyclic Compounds with Diverse Skeletons from the Roots of and Their Spasmolytic Activity.

Six undescribed macrocyclic compounds, including diarylhexanoids ( and ), a diarylhexanoid glucoside (), diarylheptanoids ( and ), and an aceroside (), were isolated from the roots of Cheval., along with 11 known analogues (-). The structures were elucidated by spectroscopic analysis, as well as by calculated optical rotatory dispersion and derivatization reactions.

Ethnobotanical study of medicinal plants used by the Yi people in Mile, Yunnan, China.

Background: The Yi people are a sociolinguistic group living in Mile City, which is their typical settlement in southeastern Yunnan, China. Over the long history of using medicinal plants, the Yi people have accumulated and developed a wealth of traditional medicinal knowledge, which has played a vital role in their health care. However, only a few studies have been performed to systematically document the medicinal plants commonly used by the Yi people.

The antinociceptive and anti-alpha-glucosidase effects of glucosides from Wall.

Wall. is commonly used in traditional Yi herbal medicine for treating bellyache and toothache. In the current study, an unreported monoterpene glucoside, ()-thymoquinol -(6--oleuropeoyl)--d-glucopyranoside (), together with 11 known glucosides were obtained from the whole herb of .

Triterpenoid saponins from Psammosilene tunicoides and their antinociceptive activities.

Herein, five undescribed oleanane-type triterpenoid saponins, namely, psammosaponins A-E, along with nine known compounds, were isolated from the roots of Psammosilene tunicoides. Moreover, part of the ethanolic extract of P. tunicoides was acid-hydrolyzed and three aglycones were isolated from the resulting hydrolysate.

Antinociceptive activity of doliroside B.

Context: Linn (Leguminosae) is often used in Yi ethnic medicine to treat pain, fracture, and rheumatism.

Objective: To explore the therapeutic potential of doliroside B (DB) from and its disodium salt (DBDS) and the underlying mechanism in pain.

Materials And Methods: In the writhing test, Kunming mice were orally treated with DB and DBDS at doses of 0.

Two new monoterpene esters from Dunn roots.

Two new monoterpene esters, illigerates H and I ( and ), and six known compounds actinodaphine (), bulbocupnine (), stephanine (), hypserpanine B (), betulinic acid () and gallic acid () were obtained from the root of Dunn. Their structures were elucidated by spectroscopic analysis. Anti-inflammatory and α-glucosidase inhibitory activity of some isolated compounds were assessed.

A Voice Cloning Method Based on the Improved HiFi-GAN Model.

With the aim of adapting a source Text to Speech (TTS) model to synthesize a personal voice by using a few speech samples from the target speaker, voice cloning provides a specific TTS service. Although the Tacotron 2-based multi-speaker TTS system can implement voice cloning by introducing a d-vector into the speaker encoder, the speaker characteristics described by the d-vector cannot allow for the voice information of the entire utterance. This affects the similarity of voice cloning.

Cytotoxic flavanes from Uraria clarkei.

Two new flavanes, (2R)-4'-hydroxy-2',5,7-trimethoxyflavane (1) and (2R,4R)-2',4'-dihydroxy-5,7-dimethoxyflavan-4-ol (2), were isolated from Uraria clarkei, together with two known compounds 5,7-dimethoxy-4'-hydroxyflavan (3) and 5,7,4'-trimethoxyflavan (4). The structures of the new flavanes were characterized by analyses of the MS, IR, UV, CD, 1D, and 2D NMR data. Cytotoxicity test suggested that compounds 1-4 possessed slight activity against K-562 and Hela cell lines, with the IC50 values ranging from 26.