GPR65 contributes to constructing immunosuppressive microenvironment in glioma.

Glioma, especially glioblastoma patients, present highly heterogeneous and immunosuppressive microenvironment, leading to their poor response to treatment and survival. Targeting the tumor microenvironment is considered a promising therapeutic strategy. M2 macrophages are highly infiltrated in glioma tissue, even up to 50% of the total number of bulk tissue cells.

Ultrasonic-Assisted Preparation of Biodiesel Products from Vegetable Oils.

Utilizing vegetable oil as a sustainable feedstock, this study presents an innovative approach to ultrasonic-assisted transesterification for biodiesel synthesis. This alkaline-catalyzed procedure harnesses ultrasound as a potent energy input, facilitating the rapid conversion of extra virgin olive oil into biodiesel. In this demonstration, the reaction is run in an ultrasonic bath under ambient conditions for 15 min, requiring a 1:6 molar ratio of extra virgin olive oil to methanol and a minimum amount of KOH as the catalyst.

NCAPH serves as a prognostic factor and promotes the tumor progression in glioma through PI3K/AKT signaling pathway.

Non-SMC (Structural Maintenance of Chromosomes) condensin I complex subunit H (NCAPH) has been shown to facilitate progression and predict adverse prognostic outcome in many cancer types. However, the function of NCAPH in gliomas is still unclear. Series of experiments were taken to uncover the function of NCAPH in glioma.

TCAF2 drives glioma cellular migratory/invasion properties through STAT3 signaling.

Glioma is an intracranial tumor characterized by high mortality and recurrence rates. In the present study, the association of TRPM8 channel-associated factor 2 (TCAF2) in glioma was investigated using bioinformatics, showing significant relationships with age, WHO grade, IDH, and 1p/19q status, as well as being an independent predictor of prognosis. Immunohistochemistry of a glioma sample microarray showed markedly increased TCAF2 expression in glioblastoma relative to lower-grade glioma, with elevated expression predominating in the tumor center.

PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma.

The tumor immunosuppressive microenvironment (IME) significantly affects tumor occurrence, progression, and prognosis, but the underlying molecular mechanisms remain to make known. We investigated the prognostic significance of PDPN and its role in IME in glioma. Weighted gene co-expression network analysis (WGCNA) found PDPN closely related to IDH wildtype status and higher immune score.

A Novel Prognostic Signature Based on Glioma Essential Ferroptosis-Related Genes Predicts Clinical Outcomes and Indicates Treatment in Glioma.

Background: Ferroptosis is a form of programmed cell death (PCD) that has been implicated in cancer progression, although the specific mechanism is not known. Here, we used the latest DepMap release CRISPR data to identify the essential ferroptosis-related genes (FRGs) in glioma and their role in patient outcomes.

Methods: RNA-seq and clinical information on glioma cases were obtained from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA).

Interactions between Active Ingredient Ranitidine and Clay Mineral Excipients in Pharmaceutical Formulations.

Excipients play an important role in pharmaceutical formulations. Many clay minerals, because of their large specific surface area and inert behaviour in reactions with active ingredients, are commonly used as excipients. In this study, the uptake of ranitidine (RT), the active ingredient of Zantac, on and released from palygorskite (Pal), kaolinite (Kao), and talc was evaluated under different physicochemical conditions.

Formation of a metalloporphyrin-based nanoreactor by postsynthetic metal-ion exchange of a polyhedral-cage containing a metal-metalloporphyrin framework.

A change for the better: Exchange of Cd(II) in the catalytically inactive framework MMPF-5 (see scheme) with Co(II) afforded a metalloporphyrin-based nanoreactor, MMPF-5(Co). This framework, consisting of small cubicuboctahedral cages, demonstrated interesting performances in the catalytic epoxidation of trans-stilbene with tBuOOH.

A porous covalent porphyrin framework with exceptional uptake capacity of saturated hydrocarbons for oil spill cleanup.

A highly porous porphyrin-based organic polymer, PCPF-1, was constructed via homo-coupling reaction of the custom-designed porphyrin ligand, 5,10,15,20-tetrakis(4-bromophenyl)porphyrin. PCPF-1 possesses a large BET surface area of over 1300 m(2) g(-1) (Langmuir surface area of over 2400 m(2) g(-1)) and exhibits strong hydrophobicity with a water contact angle of 135°, and these features afford it the highest adsorptive capacities for saturated hydrocarbons and gasoline among sorbent materials reported thus far, as well as render it the capability to remove oil from water.

Quest for highly porous metal-metalloporphyrin framework based upon a custom-designed octatopic porphyrin ligand.

A porous metal-metalloporphyrin framework, MMPF-2, has been constructed from a custom-designed octatopic porphyrin ligand, tetrakis(3,5-dicarboxyphenyl)porphine, that links a distorted cobalt trigonal prism secondary building unit. MMPF-2 possesses permanent microporosity with the highest surface area of 2037 m(2) g(-1) among reported porphyrin-based MOFs, and demonstrates a high uptake capacity of 170 cm(3) g(-1) CO(2) at 273 K and 1 bar.

Porous double-walled metal triazolate framework based upon a bifunctional ligand and a pentanuclear zinc cluster exhibiting selective CO2 uptake.

The self-assembly of a custom-designed bifunctional ligand featuring both 1,2,3-triazolate and carboxylate donor groups with a pentanuclear zinc cluster generated in situ affords a double-walled metal triazolate framework (MTAF) material, MTAF-1 (Zn(5)(μ(3)-O)(2)(C(9)N(3)H(5)O(2))(5)(H(+))(4)(H(2)O)(17)(C(3)H(7)NO)(10)), which exhibits a surface area of 2300 m(2)/g and demonstrates interesting selective CO(2) uptake performances.

Three-dimensional porous metal-metalloporphyrin framework consisting of nanoscopic polyhedral cages.

An unprecedented nanoscopic polyhedral cage-containing metal-metalloporphyrin framework, MMPF-1, has been constructed from a custom-designed porphyrin ligand, 5,15-bis(3,5-dicarboxyphenyl)porphine, that links Cu(2)(carboxylate)(4) moieties. A high density of 16 open copper sites confined within a nanoscopic polyhedral cage has been achieved, and the packing of the porphyrin cages via an "ABAB" pattern affords MMPF-1 ultramicropores which render it selective toward adsorption of H(2) and O(2) over N(2), and CO(2) over CH(4).

Immobilization of MP-11 into a mesoporous metal-organic framework, MP-11@mesoMOF: a new platform for enzymatic catalysis.

Microperoxidase-11 has for the first time been successfully immobilized into a mesoporous metal-organic framework (MOF) consisting of nanoscopic cages and it demonstrates superior enzymatic catalysis performances compared to its mesoporous silica counterpart.

Hydrogencyanamido bridged multinuclear copper(II) complexes: from strong antiferromagnetic couplings to weak ferromagnetic couplings.

In the presence of ammonia, the reactions of cyanamide and Cu(II) ions with different organic blocking ligands afford three hydrogencyanamido bridged dinuclear complexes: [(dmbpy)(4)Cu(2)(HNCN)](ClO(4))(3)·H(2)O (1, dmbpy = 4,4'-dimethyl-2,2'-bipyridine), [(phen)(4)Cu(2)(HNCN)](ClO(4))(3)·2H(2)O (2, phen = 1,10-phenanthroline) and [(bpy)(2)Cu(2)(HNCN)(2)(ClO(4))(2)] (3, bpy = 2,2'-bipyridine), respectively. However, using the di(2-pyridyl)ketone (dpk) ligand in similar experimental conditions, an interesting reaction between the hydrogencyanamido anion and dpk is observed. Using Cu(ClO(4))·6H(2)O or Co(ClO(4))·6H(2)O as the metal source, it gives the mixed bridged hexanuclear complex [(dpk·OMe)(4)(dpk·NCN)(2)Cu(6)(H(2)O)(2)](ClO(4))(4) (4), or the mononuclear complex [(dpk·OMe)(dpk·HNCN)Co](ClO(4))·2H(2)O (5), respectively.

Introduction of cavities up to 4 nm into a hierarchically-assembled metal-organic framework using an angular, tetratopic ligand.

Cavities up to 4 nm have been introduced into a hierarchically-assembled metal-organic framework by adopting an angular, semi-flexible tetratopic ligand. The resulting MOF possesses permanent porosity and exhibits stepwise sorption isotherms for O(2) and N(2) gases.

Metal-organic frameworks with exceptionally high methane uptake: where and how is methane stored?

Metal-organic frameworks (MOFs) are a novel family of physisorptive materials that have exhibited great promise for methane storage. So far, a detailed understanding of their methane adsorption mechanism is still scarce. Herein, we report a comprehensive mechanistic study of methane storage in three milestone MOF compounds (HKUST-1, PCN-11, and PCN-14) the CH(4) storage capacities of which are among the highest reported so far among all porous materials.

A large-surface-area boracite-network-topology porous MOF constructed from a conjugated ligand exhibiting a high hydrogen uptake capacity.

A new porous metal-organic framework, PCN-20 with a twisted boracite net topology, was constructed based on a highly conjugated planar tricarboxylate ligand; PCN-20 possesses a large Langmuir surface area of over 4200 m(2)/g as well as demonstrates a high hydrogen uptake capacity of 6.2 wt % at 77 K and 50 bar.

Preparation and gas adsorption studies of three mesh-adjustable molecular sieves with a common structure.

Solvothermal reactions of a predesigned amphiphilic ligand, 4'-tert-butyl-biphenyl-3,5-dicarboxylate (BBPDC), with Zn(NO(3))(2), Co(NO(3))(2), and Cu(NO(3))(2) gave rise to three isostructural mesh-adjustable molecular sieves (MAMSs), MAMS-2, MAMS-3, and MAMS-4, respectively. The three new MAMSs all exhibit temperature-tuned molecular sieving effect. There exists a linear relationship between mesh size and temperature, D = D(0) + alphaT (D, mesh size at temperature T K; D(0), mesh size at 0 K; and alpha, constant).

Microporous lanthanide metal-organic frameworks containing coordinatively linked interpenetration: syntheses, gas adsorption studies, thermal stability analysis, and photoluminescence investigation.

Under solvothermal conditions, the reactions of trigonal-planar ligand, TATB (4,4',4''-s-triazine-2,4,6-triyl-tribenzoate) with Dy(NO(3))(3), Er(NO(3))(3), Y(NO(3))(3), Yb(NO(3))(3), gave rise to four microporous lanthanide metal-organic frameworks (MOFs), designated as PCN-17 (Dy), PCN-17 (Er), PCN-17 (Y), and PCN-17 (Yb), respectively. The four porous MOFs are isostructural, with their crystal unit parameters shrinking in the order of PCN-17 (Dy), PCN-17 (Y), PCN-17 (Er), and PCN-17 (Yb), which also reflects the lanthanides' contraction trend. All of them adopt the novel square-planar Ln(4)(mu(4)-H(2)O) cluster as the secondary building unit and contain coordinatively linked doubly interpenetrated (8,3)-connected nets.

Ultramicroporous metal-organic framework based on 9,10-anthracenedicarboxylate for selective gas adsorption.

An ultramicroporous metal-organic framework based on 9,10-anthracenedicarboxylate (PCN-13) has been synthesized and structurally characterized. The desolvated PCN-13 demonstrates selective adsorption of oxygen and hydrogen over nitrogen and carbon monoxide.

Metal-organic framework based on a trinickel secondary building unit exhibiting gas-sorption hysteresis.

An interpenetrating microporous metal-organic framework based on a mu3-oxotrinickel basic carboxylate secondary building unit has been synthesized and structurally characterized. It exhibits pronounced gas-sorption hysteresis and selective adsorption of carbon dioxide over methane.

A mesoporous metal-organic framework with permanent porosity.

A mesoporous metal-organic framework possessing permanent porosity has been synthesized and characterized for the first time.