Tree shrew as a new animal model for musculoskeletal disorders and aging.

Intervertebral disc degeneration (IDD), osteoarthritis (OA), and osteoporosis (OP) are common musculoskeletal disorders (MSDs) with similar age-related risk factors, representing the leading causes of disability. However, successful therapeutic development and translation have been hampered by the lack of clinically-relevant animal models. In this study, we investigated the potential suitability of the tree shrew, a small mammal with a close genetic relationship to primates, as a new animal model for MSDs.

"Raman plus X" dual-modal spectroscopy technology for food analysis: A review.

Raman spectroscopy, a nondestructive optical technique that provides detailed chemical information, has attracted growing interest in the food industry. Complementary spectroscopic methods, such as near-infrared (NIR) spectroscopy, nuclear magnetic resonance (NMR), terahertz (THz) spectroscopy, laser-induced breakdown spectroscopy (LIBS), and fluorescence spectroscopy (Flu), enhance Raman spectroscopy's capabilities in various applications. The integration of Raman with these techniques, termed "Raman plus X," has shown significant potential in agri-food analysis.

Efficient and Robust Europium(III)-Based Hybrid Lanthanide Scintillators for Advanced X-ray Imaging.

Scintillators that convert ionizing radiation into low-energy photons are essential for medical diagnostics and industrial inspections. Despite advances in X-ray scintillators, challenges remain in achieving high efficiency, environmental compatibility, stability, and flexibility. Here, we present experimental investigations of a new type of europium(III)-based hybrid ternary complex scintillators for improved X-ray detection and imaging.

[Structural equation analysis and modeling of wrist WMSDs and its adverse ergonomic factors].

To investigate the relationships and impacts between various occupational ergonomic hazards and hand and wrist fatigue, as well as work-related musculoskeletal disorders (WMSDs) of the hand and wrist, and to propose targeted preventive and intervention measures for adverse occupational ergonomic factors causing WMSDs of the hand and wrist. From 2018 to December 2023, a nationwide epidemiologic survey study of wrist WMSDs was conducted using the Chinese version of the electronic questionnaire system for musculoskeletal disorders.A total of 88, 609 valid questionnaires were collected.

[Study on the epidemiological characteristics of work-related musculoskeletal disorders among 29 industries or occupational groups in China].

To analyze the distribution characteristics of work-related musculoskeletal disorders (WMSDs) among the occupational population in China's key industries during the period from 2018 to 2023, and to provide data support for the formulation of targeted prevention strategies. Between January 1, 2018, and December 31, 2023, a cross-sectional epidemiological survey and a retrospective investigation were conducted in seven geographical regions of North China, East China, Central China, South China, Southwest China, Northwest China, and Northeast China, using a combination of epidemiological cross-sectional and retrospective surveys. The industries were stratified according to the degree of closeness to WMSDs, the size of the occupational population, and the importance of the national economy, and then cluster sampling was conducted according to the size of the enterprises (large, medium, and small) within each stratum.

Comparison of Two-Point Versus Three-Point Fixation in Treatment of Zygomaticomaxillary Complex Fractures: An Updated Meta-Analysis.

Purpose: Zygomaticomaxillary complex (ZMC) fractures are a prevalent form of craniofacial trauma. However, no universally accepted fixation method has been established to prevent postreduction displacement in ZMC fractures.

Methods: Computerized and additional manual searches of the Medline, Embase, Chinese National Knowledge Infrastructure, and Cochrane Central database for potential studies, published from inception to May 2024, were performed.

Tissue-specific vitellogenesis and 17β-estradiol facilitate ovarian maturation of the swimming crab Portunus trituberculatus.

The present study investigated the changes of expression and localization of PtVg mRNA, tissue Vg/ Vn concentrations, the contents of progesterone and 17ß-estradiol during the ovarian development of P. trituberculatus. The results showed that: 1) The most abundant mRNA levels of PtVg were found in stage IV, and hepatopancreatic PtVg mRNA was markedly greater than that in ovaries from stage II to stage V.

MCP-enhanced SOD3 activity inhibits gastric cancer and potentiate chemotherapy via modulating EGFR signaling.

Aims: This study aims to investigate the role of SOD3 in gastric cancer (GC) progression and its impact on chemotherapy efficacy and toxicity. It further seeks to evaluate the therapeutic potential of MCP in enhancing SOD3 activity to improve treatment outcomes and reduce chemotherapy-induced peripheral neurotoxicity (CIPN).

Materials And Methods: We used overexpression plasmids and small interfering RNAs (siRNAs) to modulate the expression of SOD3 and Desmocollin2 (DSC2) in gastric cancer cells.

C-C motif chemokine ligand 5 contributes to radon exposure-induced lung injury by recruiting dendritic cells to activate effector T helper cells.

Radon (Rn) is a naturally occurring radioactive gas, ionizing radiation emitted by the radon induces oxidative stress and the up-regulation of inflammatory proteins, which may cause lung damage or cancer. However, the underlying pathogenesis remains to be determined. effector T helper cells are key in mediating the host's protection and immune homeostasis.

Liangxue Tongyu Prescription exerts neuroprotection by regulating the microbiota-gut-brain axis of rats with acute intracerebral hemorrhage.

Liangxue Tongyu Prescription (LTP) is a classic herbal formula for treating acute intracerebral hemorrhage (AICH) in China. Previous studies have shown that LTP significantly ameliorates neurological impairments and gastrointestinal dysfunction in patients with AICH. However, the underlying molecular mechanism remains unclear.

Identification of the linear Fc-binding epitope on the bovine IgG1 Fc receptor of (boFcγRI) using synthetic peptides.

Background: Bovine IgG1 Fc receptor (boFcγRI) is a homologue to human FcγRI (CD64) that has three extracellular Ig-like domains and can bind bovine IgG1 with high affinity. Identification of the linear epitope for Fc-binding on boFcγRI provides new insights for the IgG-Fcγ interaction and FcγR-targeting drugs development.

Methods: The boFcγRI molecules were expressed on cell surface of the boFcγRI -transfected COS-7 cells.

The psychological disorder and personality traits of individuals with pulmonary nodules.

Introduction: With the widespread use of Low-dose computed tomography (LDCT) in the chest, more and more people will be detected with pulmonary nodules. The presence of uncertainty following the detection of these nodules can impose significant psychological distress. This study aimed to investigate personality traits, psychological distress, and their impact on pulmonary nodule patients in China.

Structural and physicochemical properties of debranched lotus seed starch treated with high hydrostatic pressure.

Lotus seeds represent a significant economic crop and are abundant in starch. To further enhance their application value, this study investigates the structural characteristics of lotus seed starch (LS) under the combined influence of pullulanase and high hydrostatic pressure (HHP). Pullulanase increased amylose content from 39.

Integrated bioinformatics and multi-omics to investigate the mechanism of Rhododendron molle Flos-induced hepatotoxicity.

Ethnopharmacological Relevance: Drug-induced liver injury (DILI) is an important and common adverse drug event. Rhododendron molle Flos (RMF), as one of toxic Traditional Chinese medicines (TCMs), holds a prominent position in clinical practice for treating rheumatoid arthritis. However, the toxicity of RMF limits its safe.

Correlation between Neuroimaging Scores and Carotid Artery Ultrasound Features in Cerebral Small Vessel Disease Patients.

Introduction: The recently proposed cerebral small vessel disease (CSVD) score system may help to capture the overall burden of CSVD. This study aimed to investigate the associations between carotid artery ultrasound features and the burden score and cognitive performance of CSVD patients.

Methods: This is a cross-sectional analysis of an ongoing prospective study.

Liquid chromatography coupled with high resolution mass spectrometry reveals the inhibitory effects of Huangkuisiwu formula on biosynthesis of protein-binding uremic toxins in rats with chronic kidney disease.

Chronic kidney disease (CKD) is recognized as a common disorder worldwide. Protein-binding uremic toxins that cannot be efficiently removed by extracorporeal renal replacement therapies, such as indoxyl sulfate (IS) and p-cresyl sulfate (PCS), are associated with high risks of cardiovascular complications and high mortality in CKD population. This study aimed to explore the therapeutical effects of Huangkuisiwu formula (HKSWF) on CKD rats.

Electroacupuncture promotes resolution of inflammation by modulating SPMs via vagus nerve activation in LPS-induced ALI.

During the process of acute lung injury (ALI) associated with sepsis, the α7nAChR in the cholinergic anti-inflammatory pathway (CAP) plays a crucial role. However, the roles of electroacupuncture (EA) and specialized pro-resolving mediators (SPMs) in this context remain unclear. In this study, we demonstrated that EA activates CAP via α7nAChR, reducing lung permeability and inflammatory cytokine release.

The characterization of tumor immune microenvironment after neoadjuvant immunotherapy in head and neck squamous cell cancer using multiplex immunohistochemistry.

Objective: Optimizing clinical decision-making in head and neck squamous cell carcinoma (HNSCC) is challenging due to the ambiguous understanding of the immune cell dynamics and immune checkpoints regulation in the disease after the administration of neoadjuvant immunotherapy (NIT).

Methods: HNSCC biopsy samples collected before and after the neoadjuvant treatment are classified into the pathologic response (PR) and the non-pathologic response (NPR) groups according to treatment responses and the expression of immune cells and checkpoints was labeled using multiplex immunohistochemistry (m-IHC).

Results: The populations of CD4 T cells, CD8 T cells, regulatory T cells (Treg), PD-1, and PD-L1 were particularly higher in the PR group than the NPR group in pre-treatment tissues, with the p-values of log-transformed positive cell density <0.

Molecular and sensory characterization of Chinese Baijiu aged in Jiuhai container and contribution of volatile odorous terpenes to Jiuhai-aroma.

Baijiu aged in Jiuhai container will produce a special Jiuhai-aroma, which has not been fully studied. In this study, check-all-that-apply method and quantitative descriptive analysis were used to characterize Jiuhai-aroma, and it was found that the aroma characteristics of herbs, spicy, cut hay and woody were prominent in Baijiu aged in Jiuhai container. According to the results of GC-O and quantification, 71 odorants were identified in Jiuhai sample.

Defect-regulated MnS@NiCoSeS structures: A novel approach to unlock energy storage potential in supercapacitors.

Transition metal sulfides (TMSs) have significant potential in energy storage applications due to their high theoretical capacity and diverse reaction mechanisms. However, performance limitations in supercapacitors arise from various intrinsic defects, including low active material utilization and poor cycling stability caused by unstable electrical conductivity. To address these issues, this paper incorporates selenium atoms into sulfides, aiming to leverage selenium's high conductivity to enhance the electroactivity of transition metal sulfides.

Self-healing, deformable and safe integrated supercapacitor enabled by synergistic effect of multiple physical interactions in gel polymer electrolyte with dual-role Co.

With the rapid development of wearable electronic devices, flexible supercapacitors have gained strong interest. However, traditional sandwich supercapacitors have weak interfacial binding, resulting in high interface resistance and poor deformability. Herein, a self-healing integrated supercapacitor based on a polyacrylic acid-polyisodecyl methacrylate-CoSO gel polymer electrolyte (GPE) was developed.

Mechanism of oxygen vacancy engineering CoO/FeO regulated electrocatalytic reduction of nitrate to ammonia.

To enhance the activity of the nitrate reduction reaction (NORR), the development of oxygen vacancies electrocatalysts is a promising approach for improving the efficiency of ammonia synthesis. However, the mechanism by which oxygen vacancies regulate NORR to ammonia remains poorly understood. In this study, a series of CoO/FeO composite catalysts derived from ZIF-67 containing oxygen vacancies (OVs) were synthesized to elucidate the role of OVs on the activity and selectivity of ammonia synthesis.