Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study.

This study aimed to investigate the effects of physical multimorbidity on the trajectory of cognitive decline over 17 years and whether vary across wealth status. The study was conducted in 9035 respondents aged 50+ at baseline from nine waves (2002-2019) of the English Longitudinal Study of Aging. A latent class analysis was used to identify patterns of physical multimorbidity, and mixed multilevel models were performed to determine the association between physical multimorbidity and trajectories of cognitive decline.

Prognostic value and immune landscapes of disulfidptosis‑related lncRNAs in bladder cancer.

Disulfidptosis, which was recently identified, has shown promise as a potential cancer treatment. Nonetheless, the precise role of long non-coding RNAs (lncRNAs) in this phenomenon is currently unclear. To elucidate their significance in bladder cancer (BLCA), a signature of disulfidptosis-related lncRNAs (DRlncRNAs) was developed and their potential prognostic significance was explored.

The impact of immune-related adverse events on the outcome of advanced gastric cancer patients with immune checkpoint inhibitor treatment.

Background: The occurrence of immune-related adverse events (irAEs) seemed to be associated with better outcomes in advanced gastric cancer (AGC) patients. However, research focusing on the impact of the single-organ irAE (uni-irAE) or multi-organ irAEs (multi-irAEs) on the AGC outcome is relatively limited. In this study, we investigated individually the impact of the different irAEs on AGC survival as well as the co-occurrence patterns of multi-irAEs.

Novel rhesus macaque immunoglobulin germline genes identified by three sequencing approaches.

Introduction: Rhesus macaques have long been a focus of research for understanding immune responses to human pathogens due to their close phylogenetic relationship with humans. As rhesus macaque antibody germlines show high degrees of polymorphism, the spectrum of database-covered genes expressed in individual macaques remains to be determined.

Methods: Here, four rhesus macaques infected with SHIV became a study of interest because they developed broadly neutralizing antibodies against HIV-1.

Erratum: Regulation of ezrin tension by S-nitrosylation mediates non-small cell lung cancer invasion and metastasis: Erratum.

[This corrects the article DOI: 10.7150/thno.32479.

Correction: Reconstructing the phase of vanadium oxides enables redox-catalysis manipulated reversible sulfur conversion for stable Zn-S batteries.

[This corrects the article DOI: 10.1039/D4SC06593J.].

Efficacy of Hongjing I granule, an herbal medicine, in patients with mild to moderate erectile dysfunction in a randomized controlled trial.

Background: HJIG is a potential treatment for erectile dysfunction (ED) that has been used in China for over 20 years. We conducted a multi-center, double-blind, randomized, placebo-controlled trial to evaluate the effectiveness and safety of the Chinese Herbal Medicine, Hongjing I granule (HJIG), in patients with mild to moderate erectile dysfunction (ED).

Methods: This study is structured as a randomized, double-blind, placebo-controlled trial, executed across multiple centers.

The complete mitochondrial genome of an important medicinal plant, (Gaertn.) DC., 1845 (Lamiales, Orobanchaceae).

, an extensively utilized Chinese herbal medicine, is highly valued for its medicinal properties. In this study, the complete mitochondrial genome (mitogenome) of was sequenced and assembled for the first time. The mitogenome is 547,032 bp in length, with an overall GC content of 44.

Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review.

The inner ear sensory epithelium consists of two major types of cells: hair cells (HCs) and supporting cells (SCs). Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have long been elucidated. SCs are indispensable components of the sensory epithelia, and they maintain the structural integrity and ionic environment of the inner ear.

Interpreting the Additive Components of Multi-Species Distributional Aggregation: II. Species-Level Insights.

The conspecific encounter index can be further decomposed into two components, which represent two ecological processes.

Symmetry Breaking of FeN4 Moiety via Edge Defects for Acidic Oxygen Reduction Reaction.

Fe-N-C catalysts, with a planar D4h symmetric FeN4 structure, show promising as noble metal-free oxygen reduction reaction catalysts. Nonetheless, the highly symmetric structure restricts the effective manipulation of its geometric and electronic structures, impeding further enhancements in oxygen reduction reaction performance. Here, a high proportion of asymmetric edge-carbon was successfully introduced into Fe-N-C catalysts through morphology engineering, enabling the precise modulation of the FeN4 active site.

Efficacy and safety of tirofiban in acute ischemic stroke patients with ideal reperfusion: A cohort study of LAA and CE subgroups.

Background And Objectives: Despite achieving ideal reperfusion (eTICI = 3) through endovascular treatment (EVT), some acute ischemic stroke (AIS) patients still experience poor outcomes. This study aims to evaluate the efficacy and safety of tirofiban in AIS patients with ideal reperfusion, focusing on its effects in large artery atherosclerosis (LAA) and cardioembolic (CE) stroke.

Methods: A total of 474 AIS patients from the RESCUE-BT database were included.

Insect Cytochrome P450 Database: An Integrated Resource of Genetic Diversity, Evolution and Function.

Insects, the most numerous and diverse group of animal species on Earth, have important interactions with humans through providing resources, transmitting diseases and damaging agricultural cultivars. Cytochrome P450 monooxygenases (P450s) are one of the most important protein families in insects implicated in the endogenous metabolism and detoxification of xenobiotics, including allelochemicals, insecticides and environmental pollutants. To better understand the evolution and function of insect P450s and support the development and application of insecticides for pest control, an integrated bioinformatics platform is highly desirable.

Energy-Saving Electrochemical Hydrogen Production via Amorphous CoMoP/NF Bifunctional Catalyst Coupled with HMF Oxidation Reactions in Alkaline Electrolyte.

To improve water splitting efficiency and enhance energy utilization, it is crucial to develop catalysts with excellent activity, long-term stability, and low cost. In this study, we synthesized a three-dimensional nanostructured amorphous CoMoP/NF bifunctional catalyst for both the hydrogen evolution reaction (HER) and the 5-hydroxymethylfurfural oxidation reaction (HMFOR), using a sacrificial template method. Benefiting from element doping regulation and morphology control, CoMoP/NF exhibited outstanding catalytic activity.

Facile Fabrication of Monodisperse Vinyl Hybrid Core-Shell Silica Microsphere with Short Range Radial Channel in bi-phase System.

The development of monodisperse hybrid silica microspheres with highly regular pore structure and uniform distribution of functional groups have significant value in the biomolecular separation field. In this work, the short range ordered pore channels are precisely constructed onto the non-porous silica microsphere surface by a bi-phase assembly method, and the cylindrical silica channel introduced a plethora of vinyl groups by "one-pot" co-condensation to form vinyl hybrid silica shell. As hydrophilic interaction chromatography (HILIC) stationary phase, the vinyl hybrid core-shell silica microsphere is simply modified with zwitterion glutathione (SiO@SiO-GSH), in which the HILIC enrichment process is significantly shortened due to its specific porous characteristics.

"Turn-on-off" Fluorescent Probes Based on Carbon Nanoparticles for Hypochlorite and Fe Detection.

The identification of ClO and iron ions in water medium is a difficult task and has been one of the hot issues in analytical chemistry. For this objective, we synthesized carbon nanoparticles (CNPs) through a solvothermal reaction between 1, 3, 5-trimesic acid and o-phenylenediamine, which served as a sequential fluorescent probe for ClO and Fe ions. The obtained CNPs were spherical particles with a diameter of 26.

Ferroelectric Optical Memristors Enabled by Non-Volatile Electro-Optic Effect.

Memristors enable non-volatile memory and neuromorphic computing. Optical memristors are the fundamental element for programmable photonic integrated circuits due to their high-bandwidth computing, low crosstalk, and minimal power consumption. Here, an optical memristor enabled by a non-volatile electro-optic (EO) effect, where refractive index modulation under zero field is realized by deliberate control of domain alignment in the ferroelectric material Pb(MgNb)O-PbTiO(PMN-PT) is proposed.

HERC5/ISG15 Enhances Glioblastoma Stemness and Tumor Progression by mediating SERBP1protein stability.

Glioblastoma (GBM) is the most common malignant brain tumor, and has a low survival rate and a poor prognosis. Intensive studies of pathogenic mechanisms are essential for exploring therapeutic targets for GBM. In this study, the roles played by interferon-stimulated gene 15 (ISG15), HECT, RCC1-containing protein 5 (HERC5), and SERPINE1 mRNA binding protein 1 (SERBP1) in regulating GBM cell stemness were investigated.

Increased Mineral-Associated Organic Carbon and Persistent Molecules in Allochthonous Blue Carbon Ecosystems.

Coastal wetlands contain very large carbon (C) stocks-termed as blue C-and their management has emerged as a promising nature-based solution for climate adaptation and mitigation. The interactions among sources, pools, and molecular compositions of soil organic C (SOC) within blue C ecosystems (BCEs) remain elusive. Here, we explore these interactions along an 18,000 km long coastal line of salt marshes, mangroves, and seagrasses in China.

Riveting Nucleation Enabled Long Cycling Life Calcium Metal Anodes.

Calcium metal batteries with high capacity and low cost are promising alternatives to Li-ion batteries for large-scale energy storage. However, its development is crucially impeded by the irreversible Ca metal anode, which is highly associated with uncontrollable Ca plating/stripping. Here, we report a new riveting strategy to regulate the nucleation and growth of a Ca metal anode in the 3D structure of a carbon nanotube film (CNF) by introducing in situ-formed Na metal mediators.

Low-Temperature Oxidation of Methane to Methanol on a Zeolitic Octahedral Metal Oxide.

Direct oxidation of methane to methanol utilizing molecular oxygen under mild conditions is an important yet challenging process due to the difficulty in activation of methane under such conditions. In this research, we report zeolitic octahedral metal oxides based on cobalt vanadotungstates, which act as the catalysts for oxidation of methane using molecular oxygen as the oxidant without co-reductants at a low temperature of 90 oC even as low as 60 oC. This catalytic process results in the high-yield production of methanol as the major product.

Leech-Inspired Amphibious Soft Robot Driven by High-Voltage Triboelectricity.

Leech locomotion, characterized by alternating sucker attachment and body contraction provides high adaptability and stability on complex terrains. Herein, a leech-inspired triboelectric soft robot is proposed for the first time, capable of amphibious movement, climbing, and load-carrying crawling. A high-performance triboelectric bionic robot system is developed to drive and control electro-responsive soft robots.