Publications by authors named "Xirui Pei"
Transplantation
August 2024
Article Synopsis
- Islet transplantation offers hope for type 1 diabetes patients, but islet quality is often compromised by ischemic injury during cold preservation.*
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- This study investigates the effects of liraglutide, a glucagon-like peptide-1 receptor agonist, on improving islet viability and function by reducing cold-ischemic injury through mechanisms like enhancing antioxidant levels and activating Akt signaling.*
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- Results show that liraglutide supplementation during preservation significantly enhances islet outcomes in both mouse models and human islet transplants by mitigating oxidative stress.*
