Integrating multi-omics data to reveal the host-microbiota interactome in inflammatory bowel disease.

Numerous studies have accelerated the knowledge expansion on the role of gut microbiota in inflammatory bowel disease (IBD). However, the precise mechanisms behind host-microbe cross-talk remain largely undefined, due to the complexity of the human intestinal ecosystem and multiple external factors. In this review, we introduce the concept to systematically summarize how intestinal dysbiosis is involved in IBD pathogenesis in terms of microbial composition, functionality, genomic structure, transcriptional activity, and downstream proteins and metabolites.

Job involvement in heavy manual or physical work associated with epigenetic age: A Mendelian randomization study.

Engaging in heavy manual or physical work has been linked to various health outcomes, but its effect on physiological aging, as measured by epigenetic clocks, remains unclear. This study aims to analyze the causal relationship between heavy manual or physical work and epigenetic age acceleration using Mendelian randomization (MR). In this study, we explored the causal link between job involvement in heavy manual or physical work and epigenetic age acceleration measured by 4 different epigenetic clocks using 2-sample MR.

Physical activity associated with age at menopause: A Mendelian randomization study.

In previous observational studies, physical activity may have an impact on the age at menopause (ANM), potentially delaying or advancing the onset of menopause. However, the causal relationship between physical activity and age at menopause remains unclear. Therefore, we designed a 2-sample Mendelian randomization (MR) and mediation MR study to explore the causal relationship between physical activity and ANM and to identify potential mediating factors such as BMI, insomnia, hypertension and hyperglycemia.