Causal relationship between hypothyroidism and peripheral neuropathy: a Mendelian randomization study of European ancestry.

Background: Metabolic disorders are significant risk factors for peripheral neuropathy (PN) diseases. However, current clinical observational studies cannot fully determine the causal relationships between hypothyroidism (HT) and PN diseases.

Methods: We performed univariate Mendelian randomization (MR) analyses using single nucleotide polymorphisms (SNPs) associated with hypothyroidism and two diseases clinically presented as HT (autoimmune thyroid disease and benign neoplasm of the pituitary gland and craniopharyngeal duct) as instrumental variables.

Classification and identification of agricultural products based on improved MobileNetV2.

With the advancement of technology, the demand for increased production efficiency has gradually risen, leading to the emergence of new trends in agricultural automation and intelligence. Precision classification models play a crucial role in helping farmers accurately identify, classify, and process various agricultural products, thereby enhancing production efficiency and maximizing the economic value of agricultural products. The current MobileNetV2 network model is capable of performing the aforementioned tasks.

Sirtuins mediate mitochondrial quality control mechanisms: a novel therapeutic target for osteoporosis.

Mitochondria plays a role in cell differentiation and apoptosis processes. Maintaining mitochondrial function is critical, and this involves various aspects of mitochondrial quality control such as protein homeostasis, biogenesis, dynamics, and mitophagy. Osteoporosis, a metabolic bone disorder, primarily arises from two factors: the dysregulation between lipogenic and osteogenic differentiation of aging bone marrow mesenchymal stem cells, and the imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption.