Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system.

Dopaminergic system dysfunction is proved to be a possible mechanism in acrylamide (ACR) -induced neurotoxicity. The neurotransmitter dopamine (DA) has an increasingly important role in the dopaminergic system. Thus, the goal of this study is to evaluate effects of ACR on dopamine and its metabolite levels, dopamine transport and metabolic gene expression in dopaminergic neurons.

[Effects of acrylamide on rat neurobehavior, the contents of dopamine and its metabolites in nigrostriatal dopaminergic pathways].

Objective: To explore the neurotoxic effect of acrylamide on nigrostriatal dopaminergic pathways in male SD rats and its mechanism.

Methods: Fourteen male SD rats were randomly divided into 2 groups: control group, and ACR exposed group (40 mg/kg). Exposed SD rats were intragastrically administrated acrylamide (40 mg/kg) once daily for 12 days, the control rats were only administrated with normal saline by gavage.