Publications by authors named "Xiongwei Zhang"

Rhoifolin (ROF) exhibits a diverse range of biological activities, encompassing anticancer, hepatoprotective, antidiabetic, antirheumatic, and antiviral properties. However, the specific protective effects and possible mechanisms of the compound against T-cell-mediated autoimmune hepatitis have not been previously elucidated. In the present study, adult male mice were administered Con A (20 mg/kg, intravenously) for 8 h.

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Ethnopharmacological Relevance: Physical therapy is the main clinical treatment for limb symptoms after ischemic stroke, and there is a lack of reliable drug intervention programs. HouShiHeiSan (HS)comes from "Synopsis of the Golden Chamber", where it is recorded: "seauelae of wind stroke and heaviness of limbs", indicating this formulae is a promising opion for clinical practice.

Aim Of The Study: The aim of this study is to explore the therapeutic effect of HS on sarcopenia after ischemic stroke (ISS) by using the middle cerebral artery occlusion (MCAO) rats.

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Ethnopharmacological Relevance: Citri Reticulatae Pericarpium (CRP), known as Chen Pi in China, is the most commonly used medicine for regulating qi. As a traditional medicine, CRP has been extensively used in the clinical treatment of nausea, vomiting, cough and phlegm for thousands of years. It is mainly distributed in Guangdong, Sichuan, Fujian and Zhejiang in China.

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This study aims to explore the potential mechanism of action in the intervention of acute lung injury(ALI) based on the blood entry components of Ganke Granules in rats and in conjunction with network pharmacology, molecular docking, and animal experimental validation. The blood entry components of Ganke Granules in rats were imported into the SwissTargetPrediction platform to predict drug targets, and ALI-related targets were collected from the disease database. Intersections were taken, and protein-protein interaction(PPI) networks were constructed to screen the core targets, followed by Gene Ontology(GO) functional and Kyoto encyclopedia of genes and gnomes(KEGG) pathway enrichment analyses.

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Article Synopsis
  • Formononetin (FMNT) is a flavonoid found in legumes and plants, traditionally used in Asian medicine for treating inflammatory diseases, immune disorders, and cancers.* -
  • Recent studies highlight FMNT's strong anti-inflammatory and antioxidant effects, revealing its potential against various diseases linked to inflammation and oxidative stress.* -
  • FMNT displays low toxicity and promises applications in medicine, food, and cosmetics, supporting its future use in preventing and treating a range of conditions, including cancers and autoimmune diseases.*
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Percutaneous nephrolithotomy (PCNL) is the recommended treatment for 2-4-cm renal stones. Minimally invasive PCNL (MPCNL) with ≤22F sheath was frequently used instead of standard PCNL. MPCNL uses pressurized irrigation to flush out stone fragments through a conventional nephrostomy sheath (cNS), which may result in higher intrarenal pressure (IRP) and longer operating time.

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Sj9gren's syndrome(SS) is an autoimmune disease with glandular dysfunction caused by the massive infiltration of the exocrine glands by lymphocytes. The pathogenesis of this disease is related to the chronic inflammatory response of the exocrine glands due to excessive activation of B cells and T cells. In addition to dry mouth and eyes, SS can also cause damage to other organs and systems in the human body, seriously affecting the quality of life of patients.

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Ethnopharmacological Relevance: Traditional Chinese medicine has accumulated valuable experience in the treatment of inflammatory diseases caused by Ferroptosis. Jing Jie and Fang Feng are two warm acrid exterior-resolving medicinal herbs that play an important role in the prevention and treatment of inflammatory diseases. The pairing of the two forms a drug pair (Jing-Fang) that shows significant advantages in fighting oxidative stress and inflammation.

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Recurrent neural networks (RNNs) continue to show outstanding performance in sequence learning tasks such as language modeling, but it remains difficult to train RNNs for long sequences. The main challenges lie in the complex dependencies, gradient vanishing or exploding, and low resource requirement in model deployment. In order to address these challenges, we propose dynamic recurrent routing neural networks (DRRNets), which can: 1) shorten the recurrent lengths by allocating recurrent routes dynamically for different dependencies and 2) reduce the number of parameters significantly by imposing low-rank constraints on the fully connected layers.

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Background: Common carotid artery (CCA) occlusion (CCAO) is a rare condition. Owing to collateral circulation, ipsilateral internal carotid artery (ICA) and external carotid artery (ECA) are often patent.

Methods: This study included 16 patients with unilateral CCAO and patent ipsilateral ICA and ECA.

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Article Synopsis
  • The study aimed to explore the relationship between atherosclerotic plaque features and inflammation using advanced imaging techniques (18F-FDG PET/CT and MRI).
  • Analyzed data from 31 patients showed that plaques with ruptured or thin fibrous caps and those rich in lipids or hemorrhage indicated higher inflammation, based on target/background ratios (TBR).
  • The findings suggest that combining these imaging methods could improve the assessment and classification of carotid atherosclerotic plaques for better diagnosis.
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Background: Monocytes and macrophages in atherosclerotic plaque lead to plaque instability. The aim of the study was to determine if plaque neovascularization led to inflammation.

Methods: Patients were consecutively enrolled if their carotid intimal media thickness was > 2 mm, as revealed by duplex ultrasound.

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Objective: To assess the value of contrast-enhanced ultrasonography (CEUS) and fluorodeoxyglucose positron emission tomography-computed tomography (¹⁸F-FDG PET/CT) in evaluating the stability of carotid atherosclerosis.

Methods: Seventeen patients with 21 carotid artery plaques received examinations with CEUS. According to the nature of the plaques, the patients were divided into soft and mixed plaque group and hard and calcified plaque group.

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