The Role of IL-10-Producing Regulatory B Cells in Children With Primary Nephrotic Syndrome.

Aim: This study aimed to investigate the contribution of interleukin (IL)-10-producing regulatory B cells (B10 cells) to the pathogenesis of PNS.

Methods: The percentages of B10 cells, CD19CD24CD27 B cells, CD19CD24CD38 B cells, CD19CD24CD27IL-10 B cells, CD19CD24CD38IL-10 B cells, Th17 cells, and regulatory T (Treg) cells within the peripheral blood mononuclear cells (PBMCs) from healthy subjects and PNS patients with active disease or in remission were analysed by flow cytometry.

Results: The percentages and IL-10 production of circulating B10 cells and the two subsets were decreased in children with active PNS and returned to normal levels in PNS patients in remission.

Effect of CD40/CD40L signaling on IL-10-producing regulatory B cells in Chinese children with Henoch-Schönlein purpura nephritis.

The aim of the present study was to examine the role and mechanism of interleukin-10 (IL-10)-producing regulatory B cells (B10 cells) in the pathogenesis of Henoch-Schönlein purpura nephritis (HSPN). We examined the percentage of B10 cells, CD19CD24CD38 B cells, CD19CD24CD27 B cells, Th17 cells, and T regulatory (Treg) cells within the peripheral blood mononuclear cell (PBMC) population in healthy subjects and HSP/HSPN patients. The percentage of B10 cells and CD19CD24CD38 B cells was reduced in HSPN patients and that of CD19CD24CD27 B cells was decreased only in HSPN patients with hematuria and proteinuria or massive proteinuria.