Publications by authors named "Xiongfei Shi"
Blume is a traditional Chinese medicine with a long history, which has numerous pharmacological activities, such as anti-inflammation, anti-oxidation and protection of nerves. The present study investigated the regulatory effect of ethyl acetate extract of (EEGE) on the β-amyloid (Aβ) toxicity of (). First, the main components of EEGE were analyzed using high-performance liquid chromatography, and the total phenols, total flavonoids and total antioxidant capacity of EEGE were determined.
View Article and Find Full Text PDFThe aim of the present study was to investigate the protective effect of Blume (GEB) against () in Alzheimer's disease (AD) through network pharmacology. Firstly, the active constituents of GEB through ETCM and BATMAN-TCM databases were collected and its potential AD-related targets in Swiss Target Prediction were predicted. The potential targets related to AD were collected from the GeneCards, OMIM, CTD and DisGeNET databases, and the differential genes (DEGs) between the normal population and the AD patient population in GSE5281 chip of the Gene Expression Omnibus database were collected at the same time.
View Article and Find Full Text PDFIntroduction: Accumulated studies have suggested that hepatitis C virus (HCV) infection is one of the leading causes for hepatocellular carcinoma (HCC). However, the mechanisms underlying the effect of HCV on the occurrence of HCC are still poorly understood.
Methods: HCV infection datasets (GSE82177 and GSE17856) and HCC datasets (The Cancer Genome Atlas Liver Hepatocellular Carcinoma and GSE89377) were downloaded from Gene Expression Omnibus or TCGA for analysis.
Article Synopsis
- - The study investigates how miRNA-30a-5p affects pulmonary fibrosis in mice infected with Streptococcus pneumoniae by regulating autophagy via Beclin-1.
- - Mice were divided into mimics, inhibitors, and control groups to assess the impact on pulmonary function and inflammatory markers, with results showing increased injury in the mimics group and better outcomes in the inhibitors.
- - Findings indicated a significant elevation in inflammatory markers like TNF-α and IL-6 in the mimics group, while the inhibitors group demonstrated improved lung function and autophagy-related gene expression, suggesting a protective effect of miRNA-30a-5p inhibition.