Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Alleviate Nuclear Pulposus Cells Degeneration Through the miR-145a-5p/USP31/HIF-1α Signaling Pathway.

Bone marrow mesenchymal stem cell (BMSC)-derived exosomes possess therapeutic potential against degenerative diseases. This study aimed to investigate the effects of BMSC-derived exosomes on intervertebral disc degeneration (IVDD) and explore the underlying molecular mechanisms. Through transcriptome sequencing and histological analysis, we observed a significant increase in HIF-1α expression in degenerative nucleus pulposus (NP) tissues.

Comparing Clinical and Radiographic Outcomes Between the Self-locking Stand-alone Cage and Conventional Cage-plate Construct: A Five-year Retrospective Cohort Study.

Study Design/setting: A retrospective cohort study.

Objective: To evaluate the clinical efficacy of the self-locking stand-alone (SA) cage and conventional cage-plate construct (CPC) in treating degenerative cervical spondylosis with a five-year follow-up.

Summary Of Background Data: The SA approach was designed to reduce complications associated with traditional anterior cervical discectomy and fusion.

Toward Risk Reduction for Mobile Service Composition.

The advances in mobile technologies enable us to consume or even provide services through powerful mobile devices anytime and anywhere. Services running on mobile devices within limited range can be composed to coordinate together through wireless communication technologies and perform complex tasks. However, the mobility of users and devices in mobile environment imposes high risk on the execution of the tasks.

Optimal Group Size for Software Change Tasks: A Social Information Foraging Perspective.

Group size is a key factor in collaborative software development and many other cybernetic applications where task assignments are important. While methods exist to estimate its value for proprietary projects, little is known about how group size affects distributed and decentralized cybernetic applications and in particular open source software (OSS) development. This paper presents a novel approach in which we frame developers' collective resolution of OSS change tasks as a social information foraging problem.