Transcriptomic Characterization of miRNAs in Larvae Responding to Infection.

is a fungal pathogen that specifically infects bee larvae, causing an outbreak of chalkbrood disease in the bee colony and a decline in the number of bee colonies. The role of miRNA regulation in honeybees in response to infection is unclear. In this study, based on small RNA-seq, we identified the differentially expressed miRNAs (DEmiRNAs) and their regulatory networks and functions in the gut of on the first day (AcT1), the second day (AcT2) and the third day (AcT3) after infection, and analyzed the immune response mechanism of through the miRNAs-mRNA regulation network of infection.

Measuring the Effective Electro-Optic Coefficient of Low-Temperature-Prepared Lead Zirconate Titanate Thin Films.

Developing lead zirconate titanate (PZT)-based electro-optic (EO) modulators is vital for integrated photonics. The high annealing temperature required for the processing of PZT thin films restricts their compatibility with modern complementary metal-oxide-semiconductor (CMOS) technology. In this work, high-quality PZT films were fabricated on SiO/Si substrates at a low annealing temperature of 450 °C.

Effect of Bayer Red Mud on the Mechanical Strength of Grouting Material.

The massive stockpiles of Bayer-process red mud (BRM) severely compromise soil integrity, necessitating the urgent development of efficient large-scale utilization strategies. BRM contains large amounts of calcium, silicon, and aluminum. Theoretically, water glass and flue gas desulfurization gypsum (FGD) can increase the active substances in BRM, making it a cementitious raw material capable of replacing cement.

A Starch Phosphorylase, ZmPHOH, Improves Photosynthetic Recovery from Short-Term Cold Exposure in Maize.

The photosynthetic system of maize () leaves is sensitive to low temperatures and suffers from irreversible damage induced by cold exposure, making cold stress a major factor limiting maize yield. Identifying genes that improve the recovery of photosynthesis from low temperatures in maize will help enhance the cold tolerance of this crop and ensure stable yields. Here, we demonstrate the role of () in promoting photosynthetic recovery from cold damage.

Decreasing β-Catenin Leads to Altered Endothelial Morphology, Increased Barrier Permeability and Cognitive Impairment During Chronic Methamphetamine Exposure.

Cognitive impairment induced by chronic methamphetamine (METH) exposure exhibits similarities to neurodegenerative disorders and is associated with blood-brain barrier (BBB) dysfunction. However, the potential involvement of β-catenin in maintaining BBB integrity during METH exposure remains unexplored. In this study, Y-maze and novel object recognition tests were conducted to assess cognitive impairment in mice exposed chronically to methamphetamine for 2 and 4 weeks.

The Effect of on Cadmium Uptake and Gene Expression in Rice.

The molecular mechanism of arbuscular mycorrhizal fungi (AMF) in reducing cadmium (Cd) accumulation in plants remains unclear. In this respect, the effects of (Ri) inoculation under Cd stress on rice growth, the uptake of Cd along with other elements, and the expression of Cd transport genes, including , were studied using wild-type (WT) and mutant rice. The results showed that Ri inoculation did not affect rice growth.

Improved CNN Prediction Based Reversible Data Hiding for Images.

This paper proposes a reversible data hiding (RDH) scheme for images with an improved convolutional neural network (CNN) predictor (ICNNP) that consists of three modules for feature extraction, pixel prediction, and complexity prediction, respectively. Due to predicting the complexity of each pixel with the ICNNP during the embedding process, the proposed scheme can achieve superior performance compared to a CNNP-based scheme. Specifically, an input image is first split into two sub-images, i.

Serum Carnosinase 1 Is Not Associated with Insulin Resistance or Glucose Metabolism in a Type 1 Diabetes Cohort.

: Preclinical studies suggest that the deleterious effect of a high serum carnosinase 1 (CN1) concentration is attributed to its adverse effects on insulin sensitivity and glucose metabolism. However, there is little evidence for a modulating role of CN1 in glucose metabolism in humans. : We measured serum CN1 concentration in an observational type 1 diabetes cohort of 172 patients in whom glucose variability (MAGE, MODD, SD of individual blood glucose, mean, and CV) was recorded by blinded continuous glucose monitoring for 5-7 days.

Integrated Transcriptome and Proteome Analysis Provides New Insights into Starch and Sucrose Metabolism and Regulation of Corm Expansion Process in .

Unlabelled: The global significance of , a tuber crop rich in nutritional value and starch, prompts further investigation into its corm development.

Background: Previous studies have focused on starch accumulation within the tubers, yet the genetic and proteomic basis of corm expansion remains largely unexplored. This study aims to elucidate the key genes and proteins involved in this process.

Activity Evaluation and Mode of Action of ICA Against In Vitro.

Toxoplasmosis is a significant zoonotic parasitic disease. Currently, there is no effective vaccine available to prevent human infection, and treatment primarily relies on chemotherapy. However, the lack of specific therapeutic agents and the limitations of existing drugs highlight the urgent need for novel, safe, and effective anti- () medications.

Stroke-Homing Peptide-DNase1 Alleviates Intestinal Ischemia Reperfusion Injury by Selectively Degrading Neutrophil Extracellular Traps.

Neutrophil extracellular traps (NETs) act as a vital first line of defence against tissue damage and pathogens, playing a significant role in improving diseases such as intestinal ischemia reperfusion injury (IRI). However, we observed that after intestinal injury, intestinal bacteria and lipopolysaccharides (LPS) can enter the circulatory system, leading to a significant secondary increase in NETs production and the subsequent activation of a coagulation cascade. This phenomenon contributes to a pathological process known as the 'second strike' of NETs, which exaggerates intestinal damage and microcirculation disturbance.

Post-marketing safety surveillance of Amivantamab: a real world study based on the FDA adverse event reporting system.

Background: Amivantamab stands as the pioneering bispecific antibody that targets both EGFR and MET, utilized in the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EGFR ex20ins mutations. Nevertheless, a thorough assessment of its safety characteristics in the real-world remains unknown.

Research Design And Methods: The adverse event (AE) reports were collected through a search of the FDA Adverse Event Reporting System (FAERS) database spanning from 2019 Q1 to 2024 Q1, and then disproportionality analysis was utilized.

Altered synaptic homeostasis: a key factor in the pathophysiology of depression.

Depression, a widespread psychiatric disorder, is characterized by a diverse array of symptoms such as melancholic mood and anhedonia, imposing a significant burden on both society and individuals. Despite extensive research into the neurobiological foundations of depression, a complete understanding of its complex mechanisms is yet to be attained, and targeted therapeutic interventions remain under development. Synaptic homeostasis, a compensatory feedback mechanism, involves neurons adjusting synaptic strength by regulating pre- or postsynaptic processes.

Deformable registration for nasopharyngeal carcinoma using adaptive mask and weight allocation strategy based CycleFCNs model.

Background: Deformable registration plays an important role in the accurate delineation of tumors. Most of the existing deep learning methods ignored two issues that can lead to inaccurate registration, including the limited field of view in MR scans and the different scanning angles that can exist between multimodal images. The purpose of this study is to improve the registration accuracy between CT and MR for nasopharyngeal carcinoma cases.

Performance of a six-methylation-marker assay in predicting LEEP specimen histology results of cervical HSIL patients: a retrospective study.

Background: Discrepancies have been found between preoperative colposcopic biopsy results and histology results of loop electrical excision procedure (LEEP) specimens. GynTect is a six-methylation-marker assay that has demonstrated its potential as a triage tool for cervical lesion detection and prediction. The aim of this study was to evaluate the effectiveness of GynTect in predicting the histology outcomes of post-LEEP specimens.

Bifidobacterium bifidum reduces oxidative stress and alters gut flora to mitigate acute liver injury caused by N-acetyl-p-aminophenol.

Pharmacologically-induced liver injury from N-acetyl-p-aminophenol (APAP) overdose has become a leading cause of acute liver failure. Extensive research has elucidated the relationship between the intestinal microbiota and the pathophysiology of liver diseases. The growing body of evidence supporting the beneficial effects of probiotics, coupled with their established safety profile, has led to their widespread adoption in clinical practice.

Ultrasensitive photoelectric detection with room temperature extremum.

Room-temperature photodetection holds pivotal significance in diverse applications such as sensing, imaging, telecommunications, and environmental remote sensing due to its simplicity, versatility, and indispensability. Although different kinds of photon and thermal detectors have been realized, high sensitivity of photodetection with room temperature extremum is not reported until now. Herein, we find evident peaks in the photoelectric response originated from the anomalous excitonic insulator phase transition in tantalum nickel selenide (TaNiSe) for room-temperature optimized photodetection from visible light to terahertz ranges.

Role of Peripheral NLRP3 Inflammasome in Cognitive Impairments: Insights of Non-central Factors.

Cognitive impairments are common clinical manifestation of Alzheimer's disease, vascular dementia, type 2 diabetes mellitus, and autoimmune diseases. Emerging evidence has suggested a strong correlation between peripheral chronic inflammation and cognitive impairments. For example, nearly 40% of individuals with inflammatory bowel disease also suffer from cognitive impairments.

Identification of a novel signature based on RNA methylation-associated anoikis-related genes for predicting prognosis and characterizing immune landscape in colorectal cancer.

Background: RNA methylation is a potential target for cancer therapy, while anoikis, a form of programmed cell death, is linked to cancer metastasis. However, the prognostic and immune significance of RNA methylation- and anoikis-related genes in colorectal cancer (CRC) remains unknown.

Methods: Transcriptomic and clinicopathological data for CRC were obtained from TCGA and the GEO databases.

Characterization of a stable QTL for quality-related traits and its effects on yields in wheat (Triticum aestivum L.).

A total of 6 major stable QTLs and 59 pairwise epistatic eQTLs for quality-related traits were identified, and the candidate genes underlying qDt-KJ 4B, a novel major and stable QTL for dough tractility, were identified Wheat quality traits are usually negatively correlated with yield traits, but they affect the processing quality and nutritional value of wheat. Therefore, identifying more wheat quantitative trait loci (QTLs) and elucidating their genetic basis are essential for cultivating new high-quality and high-yielding wheat varieties. In this study, QTL analysis for five quality-related traits was performed on a recombinant inbred line (RIL) mapping population, KJ-RIL, derived from a cross between Kenong 9204 (KN9204) and Jing 411 (J411).

[Study on lightweight plasma recognition algorithm based on depth image perception].

In the clinical stage, suspected hemolytic plasma may cause hemolysis illness, manifesting as symptoms such as heart failure, severe anemia, etc. Applying a deep learning method to plasma images significantly improves recognition accuracy, so that this paper proposes a plasma quality detection model based on improved "You Only Look Once" 5th version (YOLOv5). Then the model presented in this paper and the evaluation system ‌were introduced‌ into the plasma datasets, and ‌the average accuracy of the final classification reached 98.

[Structural equation analysis and modeling of fect and ankles WMSDs and its adverse ergonomic factors].

To explore the structural equation model to explore the levels of work-related musculoskeletal disorders (WMSDs) and various risk factors in the feet and ankle of China's occupational population, providing scientific basis for for preventing WMSDs in feet and ankles. Data of 73497 national occupational epidemiological cases were selected from June 2018 to December 2023 used the Chinese version of the Electronic Questionnaire on Musculoskeletal Disorders. The adverse ergonomic factors and their source classification standard and confirmatory factor analysis were used to investigate foot and ankle WMSDs and their related risk factors (including individual factors, work organization, work posture, work type, fatigue, etc.

[Structural equation analysis of the incidence of shoulder WMSDs and individual and work-related factors].

To investigate the incidence of shoulder work-related musculoskeletal disorders (WMSDs) among occupational population in China, and to explore their intrinsic association with personal and work-related factors. In April 2024, 73497 valid questionnaires of the Chinese version of the Musculoskeletal Disorders Electronic Questionnaire were retrospectively analyzed from June 2018 to December 2023 in 22 provinces and 29 key industries in China, and the general information, occurrence of WMSDs and related risk factors of key occupational populations in different regions in China were collected. By using Chi-square test and confirmatory factor analysis, the relationship between shoulder fatigue and pain in key occupational groups and individual factors, work type, work posture and work organization was discussed, and the internal relationship was analyzed based on structural equation model.

A nationwide prospective registry of endovascular thrombectomy for extra-large ischemic stroke with large vessel occlusion (XL STROKE): rationale and design.

Introduction： The role of endovascular thrombectomy (EVT) for acute extra-large ischemic stroke patients with large vessel occlusion (LVO) is uncertain. We aimed to explore the clinical and safety outcomes of medical management (MM) plus EVT (EVT group) versus MM alone (MM group) among acute extra-large ischemic stroke patients with LVO within 24 hours of last known well. Methods： XL STROKE (endovascular thrombectomy for extra-large ischemic stroke) is an investigator-initiated, nationwide, prospective registry with blinded end point assessment performed at approximately 60 sites in China, and will enroll up to 990 acute ischemic stroke patients within 24 hours of last known well.

Research progress on the mechanism and treatment of cachexia based on tumor microenvironment.

Cachexia is a prevalent multifactorial syndrome characterized by a substantial decrease in food intake, which results from processes such as proteolysis, lipolysis, inflammatory activation, and autophagy, ultimately leading to weight loss. In cancer patients, this condition is referred to as cancer-related cachexia (CRC) and affects over 50% of this population. A comprehensive understanding of the intricate interactions between tumors and the host organism is essential for the development of effective treatments for tumor cachexia.