Manganese-based nanoenzymes: from catalytic chemistry to design principle and antitumor/antibacterial therapy.

Manganese (Mn)-based materials have been extensively investigated for a wide range of biomedical applications owing to their remarkable catalytic chemistry, magnetic resonance imaging (MRI) capacity, biodegradability, low toxicity, and good biosafety. In this review, we first elaborate on the catalytic principle of Mn-based nanoenzymes for antitumor and antibacterial therapy, followed by a comprehensive discussion of the interesting structural design engineering strategies used to achieve multi-dimensional Mn-based nanoarchitectures, such as zero-dimensional (0D) nanoparticles, 1D nanotubes, 2D nanosheets, 3D hollow porous Mn ball, and core-shell nanostructures. Moreover, the therapeutic applications of different Mn-based nanoenzymes, including manganese dioxide (MnO)-based nanoenzymes that can trigger catalytic reactions, Mn-doped metal nanoenzymes and Mn-coordinated nanoenzymes that promote hydroxyl/reactive oxygen species (ROS) generation, and MnO-based micro/nanorobots that can effectively penetrate tumor tissues, are critically reviewed.

Thermodynamics and kinetics of lithiation-induced phase transitions in nanoporous antimony.

The impact of nanosizing on the phase transition mechanisms of electrode materials is still not well understood. In this study, we reveal that nanosizing can lower the energy barrier and entropy changes associated with phase transformations, ultimately improving the electrochemical performance of nanoporous antimony electrodes in comparison to microsized antimony.

Early Diagnosis of Colorectal Cancer via Plasma-Derived SDC2, KCNQ5, and IKZF1 Methylation Levels.

Background: The incidence of colorectal cancer (CRC) is rapidly increasing, and early detection plays a crucial role in improving the prognosis and survival rates of patients. This study aimed to assess the diagnostic ability of combined SDC2-KCNQ5-IKZF1 methylation levels in plasma for CRC detection.

Methods: A total of 92 patients were recruited from the Department of General Surgery at the Second Hospital of Hebei Medical University, including 56 CRC patients, 22 polyp and adenoma patients, and 14 healthy controls.

Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress via ERK/JNK Pathway in Hyperplastic Prostate.

Benign prostatic hyperplasia (BPH) is a prevalent disorder in aging males. It is investigated whether heat shock protein family A member 1A (HSPA1A), a cytoprotective chaperone induced under stress, has been implicated in the development of BPH. RNA-sequencing and single-cell sequencing analyses revealed significant upregulation of HSPA1A in BPH compared to controls.

Comparative and Functional Analysis of Exosomal microRNAs During Semelparous Reproduction in Ayu Fish ().

As a life history strategy, some semelparous organisms, such as the ayu fish (), reproduce only once in their lifetime and then die. They invest heavily in their single reproductive event, producing many offspring. However, the regulatory mechanisms that trigger mortality after reproduction are not well understood.

Design of an ultrasound appointment system based on a patient-centered real-time dynamic resource allocation strategy.

Introduction: The existing ultrasound appointment system faces multiple challenges, including a lack of diversity in its operation modes, sluggish efficiency, and limited flexibility. During emergency situations, such as disease outbreaks or severe disaster events, the demand for ultrasound examinations skyrockets, making it imperative to offer patients efficient and user-friendly ultrasound appointment services.

Methods: This study introduces the application of a patient-centered real-time dynamic resource allocation strategy in an ultrasound appointment system.

miR-6089 Alleviates Inflammation and Cell Apoptosis Through Modulating the TLR4 Pathway in Mite-Sensitized Allergic Rhinitis.

Purpose: Allergic rhinitis (AR), a chronic inflammatory disease of nasal mucosa, is considered as a classic Th2-mediated disease. We aimed to elucidate the molecular mechanisms and therapeutic potential of microRNAs (miRNAs) in AR.

Methods: Nasal mucosa was collected from patients with mite-sensitized AR and non-allergic controls for miRNA and mRNA sequencing.

cultured calculus bovis alleviates cerebral ischemia-reperfusion injury in rats through regulating microglial polarization and inhibiting NLRP3.

Objectives: To investigate the effect of cultured calculus bovis (ICCB) on cerebral ischemia/reperfusion injury (CIRI) and its mechanism.

Methods: The CIRI animal model and cell model were induced by middle cerebral artery occlusion (MCAO) in Sprague Dawley rats and oxygen glucose deprivation/reperfusion (OGD/R) in BV2 cells, respectively. The CIRI of rat model was evaluated using modified neurological severity score (mNSS), brain water content, and cerebral infarction volume after 1.

Nanoscale Spatially Resolved Terahertz Response of a PbS-Graphene Heterostructure.

Heterostructures have promising applications in photonics and optoelectronics, mainly due to their high electron mobility and broadband photoresponse covering visible, infrared, and terahertz (THz) ranges. However, it is challenging to detect heterostructures in high definition with conventional THz techniques. Here we demonstrate a THz nanoscopic imaging method which is capable of resolving the local THz response of PbS-graphene heterostructures based upon a sophisticated THz near-field optical microscope.

[The regulation and mechanism of apolipoprotein A5 on myocardial lipid deposition].

The current study aimed to clarify the roles of apolipoprotein A5 (ApoA5) and milk fat globule-epidermal growth factor 8 (Mfge8) in regulating myocardial lipid deposition and the regulatory relationship between them. The serum levels of ApoA5 and Mfge8 in obese and healthy people were compared, and the obesity mouse model induced by the high-fat diet (HFD) was established. In addition, primary cardiomyocytes were purified and identified from the hearts of suckling mice.

Precise engineering of gene expression by editing plasticity.

Background: Identifying transcriptional cis-regulatory elements (CREs) and understanding their role in gene expression are essential for the precise manipulation of gene expression and associated phenotypes. This knowledge is fundamental for advancing genetic engineering and improving crop traits.

Results: We here demonstrate that CREs can be accurately predicted and utilized to precisely regulate gene expression beyond the range of natural variation.

Can cardiovascular health and its modifiable healthy lifestyle offset the increased risk of all-cause and cardiovascular deaths associated with insulin resistance?

Background: Insulin resistance(IR) is associated with an increased risk of all-cause and cardiovascular death, and modifiable healthy lifestyles play an active role in the improvement of IR and the reduction of all-cause and cardiovascular death. Whether cardiovascular health (CVH) and modifiable healthy lifestyles within it can attenuate or even offset the heightened perils of both all-cause and cardiovascular deaths associated with insulin resistance remains unclear.

Methods: The study encompassed 14,172 healthy participants from the 2005-2018 NHANES programme.

From interference to insight: pseudo-lipidemia led to the diagnosis of Waldenström macroglobulinemia.

Waldenström macroglobulinemia (WM) is a rare hematological disorder with an annual incidence of about 3 per million. Its clinical manifestations are diverse and non - specific, and approximately 30% of patients are asymptomatic, making early diagnosis challenging. This paper reports a 73-year-old female who was admitted to the hospital due to atrial fibrillation.

The effects of China-recommended gestational weight gain guidelines and the Institute of Medicine guidelines on adverse birth outcomes: A population- based cohort study.

Objectives: This study aimed to assess and compare the Institute of Medicine (IOM) guidelines and the recently published China guidelines regarding their applicability for gestational weight gain (GWG) management among Chinese pregnant women.

Method: Data were extracted from the Electronic Medical Record System of Zhoushan, China. Adverse outcomes include small for gestational age (SGA), large for gestational age (LGA), low birth weight and macrosomia.

Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation.

During homeostasis and regeneration, satellite cells, the resident stem cells of skeletal muscle, have distinct metabolic requirements for fate transitions between quiescence, proliferation and differentiation. However, the contribution of distinct energy sources to satellite cell metabolism and function remains largely unexplored. Here, we uncover a role of mitochondrial fatty acid oxidation (FAO) in satellite cell integrity and function.

Risk factors and an optimized prediction model for urosepsis in diabetic patients with upper urinary tract stones.

To identify independent risk factors for urosepsis in diabetic patients with upper urinary tract stones (UUTS) and develop a prediction model to facilitate early detection and diagnosis, we retrospectively reviewed medical records of patients admitted between January 2020 and June 2023. Patients were divided based on the quick Sequential Organ Failure Assessment (qSOFA) score. The least absolute shrinkage and selection operator (LASSO) regression analysis was used for variable selection to form a preliminary model.

Integrative single cell transcriptomic analysis reveals 3p deletion associated tumor microenvironment and chemoresistance in head and neck squamous cell carcinoma.

Head and neck squamous cell carcinoma (HNSCC) remains a prevalent and lethal malignancy, with a five-year survival rate of just 50% for cases of locally advanced disease. Chromosomal aberrations, particularly the deletion of the short arm of chromosome 3 (3p), have been strongly associated with poor prognosis and more aggressive tumor phenotypes. The tumor microenvironment (TME) plays a pivotal role in tumor progression and resistance to therapy.

Competitive antagonism of KAT7 crotonylation against acetylation affects procentriole formation and colorectal tumorigenesis.

Accurate procentriole formation is critical for centriole duplication. However, the holistic transcriptional regulatory mechanisms underlying this process remain elusive. Here, we show that KAT7 crotonylation, facilitated by the crotonyltransferase hMOF, competes against its acetylation regulated by the deacetylase HDAC2 at the K432 residue upon DNA damage stimulation.

Edaravone dexborneol for ischemic stroke with sufficient recanalization after thrombectomy: a randomized phase II trial.

phase II, randomized, double blinded, multi-center study aims to explore whether intravenous edaravone dexborneol (ED) could improve clinical outcomes in patients with anterior circulation stroke with successful endovascular reperfusion (ClinicalTrials.gov: NCT04667637 Eligible patients were randomly (1:1) assigned into ED, which received intravenous ED (37.5 mg, 2/day, for 12 days) or control group, which received placebo.

Integrated Three-in-one to Boost Nitrate Electroreduction to Ammonia Utilizing a 1D Mesoporous Carbon Cascade Nanoreactor.

The electrochemical reduction of nitrate (NO) offers a promising waste-to-value strategy for synthesizing ammonia (NH), yet it involves a complex multi-interface system with several stages such as mass transport, species enrichment, and interfacial transformation. This complexity necessitates catalysts with diverse structural characteristics across multiple temporal and spatial scales. Herein, a three-in-one nanoreactor system is designed with 1D geometry, open mesochannels, and synergistic active sites for optimized NH synthesis.

Far-red light-driven photoautotrophy of chlorophyll f-producing cyanobacterium without red-shifted phycobilisome core complex.

Chlorophyll (Chl) f production expands oxygenic photosynthesis of some cyanobacteria into the far-red light (FRL) region through reconstructed FRL-allophycocyanin (APC) cores and Chl f-containing photosystems. Presently, a unicellular cyanobacterium was isolated for studying FRL photoacclimation (FaRLiP) and classified as a new species Altericista leshanensis. It uses additional Chl f and FRL-APC cores, with retained white light (WL)-phycobiliproteins to thrive FRL conditions.

Unveiling the power of R: a comprehensive perspective for laboratory medicine data analysis.

R language has gained traction in laboratory medicine for its statistical power and dynamic tools like RMarkdown and RShiny. However, there is limited literature summarizing R packages and functions tailored for laboratory medicine, making it difficult for clinical laboratory workers to access these tools. Additionally, varying algorithms across R packages can lead to inconsistencies in published reports.

Endovascular treatment and hybrid surgery for extracranial internal carotid artery aneurysms.

Background: Extracranial internal carotid artery aneurysms (EICAAs) are rare, and both endovascular treatment and hybrid surgery have been used to treat them. Herein, we evaluated the outcomes of endovascular treatment and hybrid surgery for EICAAs treated at our institution.

Methods: Twenty-eight patients diagnosed with EICAA and treated with endovascular treatment or hybrid surgery in our center from January 2013 to June 2023 were retrospectively reviewed.

BQU57 suppresses IL-1β-induced apoptosis and extracellular matrix degradation in nucleus pulposus cells by blocking the NF-κB signaling pathway.

Background: Intervertebral disc degeneration (IVDD) is a significant contributor to lower back pain (LBP), affecting approximately 80 % of the global population. The RalA inhibitor BQU57 plays a role in various cellular functions; however, its impact on nucleus pulposus cell (NPC) degeneration remains unclear.

Methods: This study employed a combination of bioinformatics analysis and experimental validation to investigate the role of RALA in IVDD and its inhibitor BQU57 in its therapeutic potential.