Triggering Receptor Expressed on Myeloid Cell-2 Protects PC12 Cells Injury by Inhibiting BV2 Microglial Activation.

Microglia play a crucial role in the activation of immune defense mechanism as the resident macrophages in the central nervous system (CNS). Microglia can eliminate damaged neurons, plaques, and other infectious agents. Triggering receptor expressed on myeloid cell-2 (TREM-2) speculates to be beneficial in preventing inflammation-induced bystander damage of neurons.

Active Ingredients and Mechanism of Action of Rhizoma Coptidis against Type 2 Diabetes Based on Network-Pharmacology and Bioinformatics.

A pharmacological network of "component/target/pathway" for Rhizoma coptidis against type 2 diabetes (T2D) was established by network-pharmacology, and the active components of Rhizoma coptidis and its mechanism were explored. A literature-based and database study of the components of Rhizoma coptidis was carried out and screened by ADME parameters. The targets of Rhizoma coptidis were predicted by the ligand similarity method.

Network Pharmacology-based Research of Active Components of Albiziae Flos and Mechanisms of Its Antidepressant Effect.

Albiziae Flos (AF) has been experimentally proven to have an antidepressant effect. However, due to the complexity of botanical ingredients, the exact pharmacological mechanism of action of AF in depression has not been completely deciphered. This study used the network pharmacology method to construct a component-target-pathway network to explore the active components and potential mechanisms of action of AF.

A Novel Antiplatelet Aggregation Target of Justicidin B Obtained From (L.) Nees.

The present study explored the possible bioactive ingredients and target protein of (L.) Nees. Firstly, we found that the ethyl acetate extraction obtained from could inhibit platelet aggregation.

[Study on wild germplasm resoures of Begonia fimbristipula in Dinghu District, Zhaoqing City, Guangdong Province].

Objective: A systematical investigation on the distribution of wild germplasm of Regonia fimbristipula in Dinghu District, Zhaoqing City, Guangdong Province was conducted at 8 sites.

Methods: Field quadrat survey method was carried out.

Results: Begonia fimbristipula had obvious phenotypical plasticity showing three phenotypes with red, green and bicolor leaf, respectively.

[Effect of activated charcoal on rooting in tissue culture seedling of Begonia fimbristipula on Dinghushan Mountain].

Objective: To study the effect of different plant growth substance and activated charcoal on rooting in culture seedling of Begonia fimbristpula on Dinghushan mountain.

Methods: Tissue culture single factor experiment method was used.

Results: NAA 0.