Publications by authors named "Xiong-Ying Pu"
Purpose: So far, there is no gold standard to diagnosis dysthyroid optic neuropathy (DON). Diffusion kurtosis imaging (DKI) has the potential to provide imaging biomarkers for the timely and accurate diagnosis of DON. This study aimed to explore the white matter (WM) alterations in thyroid-associated ophthalmopathy (TAO) patients with and without DON using DKI with tract-based spatial statistics method.
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- The study investigates the effectiveness of dynamic contrast-enhanced MRI in evaluating thyroid-associated ophthalmopathy (TAO) and how patients respond to glucocorticoid treatment.
- A total of 65 TAO patients were analyzed, with 41 classified as active and 24 as inactive, comparing various MRI parameters to assess disease activity and treatment responses.
- Findings show that certain MRI metrics, particularly TTP-mean and V-mean, are significant in determining active disease and treatment response, with the study achieving moderate to good diagnostic performance in identifying these factors.
Article Synopsis
- The study aimed to assess how Dixon MRI-based quantitative measurements of extraocular muscles, intraorbital fat, and lacrimal glands can help in staging thyroid-associated ophthalmopathy (TAO) in patients.* -
- A total of 200 TAO patients were divided into training and validation groups, with results showing that active TAO patients had higher signal intensity and water fraction values, but lower fat fraction values, compared to inactive patients.* -
- The research concluded that using a combination of specific MRI parameters enhances the ability to differentiate and stage active versus inactive TAO more effectively than using a single parameter alone.*
Article Synopsis
- This study assesses how well combined orbital MRI and diffusion kurtosis imaging (DKI) can diagnose dysthyroid optic neuropathy (DON) in patients with thyroid-related eye issues.
- Researchers analyzed data from 61 patients, finding that those with DON had distinct imaging characteristics compared to those without, such as higher apical muscle index and lower apparent diffusion coefficient of the optic nerve.
- The integrated approach of using both MRI and DKI showed the highest diagnostic accuracy, highlighting its potential to improve the diagnosis and treatment strategies for DON.*
Increased brain iron in patients with thyroid-associated ophthalmopathy: a whole-brain analysis.
Front Endocrinol (Lausanne)
December 2023
Article Synopsis
- The study aimed to investigate iron deposition changes in the brains of patients with thyroid-associated ophthalmopathy (TAO) using a technique called quantitative susceptibility mapping (QSM).
- A total of 48 TAO patients and 33 healthy controls underwent MRI scans, and it was found that TAO patients had higher QSM values in specific brain areas, which correlated with depression and cognitive assessment scores.
- The support vector machine analysis demonstrated that QSM values could effectively differentiate TAO patients from healthy individuals, indicating their potential as neuroimaging markers for the condition.
Structural and Functional Brain Changes After Glucocorticoid Therapy in Thyroid-Associated Ophthalmopathy.
J Clin Endocrinol Metab
February 2024
Article Synopsis
- This study aimed to explore brain changes in patients with thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid treatment using advanced MRI techniques.
- Researchers compared MRI results from 32 TAO patients and 23 healthy controls, finding significant differences in brain regions related to vision and emotion, notably decreased gray matter volume in certain areas before therapy.
- Post-treatment, patients showed improvement in brain function and structure, indicating that glucocorticoids may help mitigate some brain deficits associated with TAO, while also highlighting the complex mechanisms of the disease.
Article Synopsis
- The study investigates how brain activity and connectivity change in patients with thyroid-associated ophthalmopathy (TAO) using resting-state functional magnetic resonance imaging (rs-fMRI).
- It involved 47 TAO patients and 30 healthy controls, examining variations in brain activity's temporal patterns (dALFF) and the efficiency of communication between brain regions (dFC).
- Findings revealed decreased dALFF in specific areas related to vision and increased dALFF in regions linked to emotional and cognitive functions, with altered brain activity correlating with visual acuity and quality of life related to vision.