Effect of Yb on Microstructure and Mechanical Properties of Al-Cu-Mn Heat-Resistant Aluminum Alloys.

The effect of Yb on the microstructure and tensile properties at room temperature and high temperature (350 °C) of as-cast and T6 heat-treated Al-6Cu-0.4Mn alloys was investigated. The results show that Yb can refine the α-Al primary grain and α-Al + AlCu eutectic structure.

Systemic immune inflammation mediates the association of serum omega-3 and omega-6 polyunsaturated fatty acids with biological aging: a national population-based study.

Objective: This study aimed to explore the association between serum omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and biological aging, along with the potential mediating role of systemic immune inflammation (SII).

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were used for analyses. Accelerated aging in participants was assessed by calculating the difference between phenotypic age (PhenoAge) and chronological age.

Biomass-derived carbon dots: synthesis, modification and application in batteries.

Biomass-derived carbon dots (BCDs) have attracted considerable attention for their promising attributes, including low toxicity, excellent solubility, biocompatibility, and eco-friendliness. Their rich surface chemistry and impressive photoluminescent properties have sparked widespread research interest, particularly in areas such as sensing and biomedicine. However, the potential applications of BCDs in the energy sector, especially in electrochemical energy storage batteries, have received scant review focus.

MCnebula analysis combined with alpha-glucosidase inhibitory screening reveals potential chemical contributors to efficacy enhancement of natural products after processing.

Natural products often show enhanced therapeutic effects after processing, largely due to changes in their chemical profiles. However, identifying the key chemical classes and components responsible for these improvements remains a challenge. In this study, we present a novel workflow for mass spectrometry data analysis, based on our previously developed MCnebula, combined with in vivo and in vitro testing to identify contributors to the anti-diabetic effects of processed natural products.

Synergistic microglial modulation by laminarin-based platinum nanozymes for potential intracerebral hemorrhage therapy.

Abnormal microglial activation increases inflammation, causing significant brain damage after intracerebral hemorrhage (ICH). To aid recovery, treatments should regulate oxidative stress and inhibit the M1-like phenotype (pro-inflammation) of microglia. Recently, antioxidant nanozymes have emerged as tools for modulating microglial states, but detailed studies on their role in ICH treatment are limited.

Enzymatic bioelectrodes based on ferrocene-modified metal-organic layers for electrochemical glucose detection.

Metal-organic frameworks (MOFs) are often applied for enzyme immobilization, while they are limited for bioelectrochemical applications due to poor electronic conductivity. Two-dimensional (2D) metal-organic layers (MOLs) with an ultra-thin lamellar structure can effectively shorten the electron transport path and improve the electron transfer rate. In this study, ferrocene as an electron mediator is covalently bound to a 2D-MOL (Fc-NH-Hf-BTB-MOL) to accelerate electron transfer between the electrode surface and enzyme.

Comparison of primary duct closure versus T-tube drainage in laparoscopic common bile duct exploration: a propensity score matching analysis.

Background And Aims: Laparoscopic common bile duct exploration (LCBDE) is a safe and effective method for the treatment of choledocholithiasis. However, there is still controversy in clinical practice over whether primary duct closure (PDC) or T-tube drainage (TTD) should be selected after choledochotomy. Therefore, this study aimed to compare the two methods of closing the common bile duct in order to identify the safer and more effective approach.

A case of massive hematoma: reflections on hypermobile Ehlers-Danlos syndrome.

Ehlers-Danlos Syndrome (EDS) refers to a group of connective tissue disorders characterized by significant clinical and genetic variability, affecting multiple systems in the body. Classified as a rare disease, EDS includes 14 subtypes, all marked by joint hypermobility, skin extensibility, and tissue fragility. These subtypes present with a wide range of clinical manifestations and severities, including frequent joint dislocations, scoliosis, arterial dissections, and organ ruptures.

Hsp70 incompletely disaggregates misfolded K488X-menin to promote tumourigenesis in a family with multiple endocrine neoplasia type 1.

Multiple endocrine neoplasia type 1 (MEN1) is caused by germline mutations in the MEN1 gene, including nonsense mutations and missense variants, which result in the formation of truncated inactive menin protein and some of which cause degradation of mutant menin proteins. Here, we describe a c.1462 A > T (p.

Dynamic analysis of a novel 3D chaotic map with two internal frequencies.

Trigonometric functions serving as boundary functions are excellent nonlinear elements in designing chaotic maps. However, research on the dynamical behaviors dependent on the internal frequency within these boundary functions is not yet sufficient. Hence, in this paper, a novel chaotic map is proposed.

Spastic pelvic floor syndrome and puborectalis syndrome: the different stages of the same disease.

Purpose: The diagnosis and treatment of puborectalis syndrome (PRS) and spastic pelvic floor syndrome (SPFS) are still up for debate. This study aims to investigate and examine the similarities and differences between PRS and SPFS.

Methods: This study recruited 13 PRS cases, 10 SPFS cases, and 16 controls.

Investigation on the Interaction of Dendritic Core Multi-Shell Nanoparticles with Human Red Blood Cells.

The use of nanoparticles is becoming increasingly apparent in a growing number of medical fields. To exploit the full potential of these particles, it is essential to examine their behavior in the blood and their possible interactions with blood cells. Dendritic core multi-shell DendroSol™ nanoparticles (DS-NPs) are able to penetrate into viable layers of human skin, but nothing is known about their interaction with blood cells.

A nomogram for predicting adverse perinatal outcome with fetal growth restriction: a prospective observational study.

Background: Fetal growth restriction (FGR) is a major determinant of perinatal morbidity and mortality. Our study aimed to develop a prediction model for the risk of FGR developing adverse perinatal outcome (APO) and evaluate its performance.

Methods: This was a prospective observational cohort study of consecutive singleton gestations meeting the ACOG-endorsed criteria for FGR from January 2022 to June 2023 at Obstetrics and Gynecology Hospital of Fudan University.

Coordination-in-pipe engineering of Pt-based intermetallic compounds with nanometer to angstrom precision.

The simultaneous regulation of particle size, surface coordinated environment and composition for Pt-based intermetallic compound (Pt-IMC) nanoparticles to manipulate their reactivity for energy storage is of great importance. Herein, we report a general synthetic method for Pt-IMCs using SBA-15 for coordination-in-pipe engineering. The particle size can be regulated to 3-9 nm by carrying out the coordination in pipes with different diameters and the coordination number of the interface metal atoms can be adjusted by altering the N source.

Yiqi Juanshen decoction alleviates renal interstitial fibrosis by targeting the LOXL2/PI3K/AKT pathway to suppress EMT and inflammation.

Chronic kidney disease (CKD) is a major health concern, with renal interstitial fibrosis (RIF) as a key feature. Effective management of RIF is crucial for treating CKD. Yiqi Juanshen decoction (YQJSD), as traditional Chinese medicine, has shown promising results in CKD treatment.

All-round enhancement induced by oxophilic single Ru and W atoms for alkaline hydrogen oxidation of tiny Pt nanoparticles.

Anion exchange membrane fuel cells (AEMFCs) are one of the ideal energy conversion devices. However, platinum (Pt), as the benchmark catalyst for the hydrogen oxidation reaction (HOR) of AEMFCs anodes, still faces issues of insufficient performance and susceptibility to CO poisoning. Here, we report the Joule heating-assisted synthesis of a small sized RuPt single-atom alloy catalyst loaded on nitrogen-doped carbon modified with single W atoms (s-RuPt@W/NC), in which the near-range single Ru atoms on the RuPt nanoparticles and the long-range single W atoms on the support simultaneously modulate the electronic structure of the active Pt-site, enhancing alkaline HOR performance of s-RuPt@W/NC.

PEGylation of Dipeptide Linker Improves Therapeutic Index and Pharmacokinetics of Antibody-Drug Conjugates.

Hydrophobic payloads incorporated into antibody-drug conjugates (ADCs) typically are superior to hydrophilic ones in tumor penetration and "bystander killing" upon release from ADCs. However, they are prone to aggregation and accelerated plasma clearance, which lead to reduced efficacies and increased toxicities of ADC molecules. Shielding the hydrophobicity of payloads by incorporating polyethylene glycol (PEG) elements or sugar groups into the ADC linkers has emerged as a viable alternative to directly adopting hydrophilic payloads.

Simultaneous Quantification of Total Antibody and Conjugated Payload for DS001 in Rat Serum Using a Hybrid Immuno-Capture LC-MS/MS.

Antibody-drug conjugates (ADCs) are intricate compounds that pose significant challenges in bioanalytical characterization. Therefore, multiple bioanalytical methods are required to comprehensively elucidate their pharmacokinetic (PK) profiles. In this study, we investigated DS001, an ADC consisting of a humanized monoclonal antibody (hRS7), a cleavable chemical linker, and the microtubule inhibitor monomethyl auristatin E (MMAE), with a drug-to-antibody ratio (DAR) of 8.

Hemoglobin in Submicron Particles (HbMPs) Is Stabilized Against Oxidation.

Superoxide dismutase (SOD) and Catalase (CAT) play a crucial role as the first line of defense antioxidant enzymes in a living cell. These enzymes neutralize the superoxide anion from the autooxidation of oxyhemoglobin (Oxy-Hb) and convert hydrogen peroxides into water and molecular oxygen. In this study, we fabricated hemoglobin submicron particles (HbMPs) using the Coprecipitation Crosslinking Dissolution (CCD) technique and incorporating first-line antioxidant enzymes (CAT, SOD) and second-line antioxidant (ascorbic acid, Vit.

Substance migration in the synthesis of single-atom catalysts.

Substance migration is universal and crucial in the synthesis of catalysts, which directly affects their existing form and the micro-structure of their active sites. Realizing migration during the synthesis of single-atom catalysts (SACs) is beneficial for not only increasing their metal loading capacity but also manipulating the electronic structures (coordination structure, long-range interactions, ) of their metal sites. This review summarizes the thermodynamics and kinetic processes involved in the synthesis of SACs to unveil the fundamental principles involved in their synthesis.

Quantification of serum daratumumab in multiple myeloma patients by LC-MS/MS, comparison with ELISA.

Daratumumab is a fully human immunoglobulin G1 monoclonal antibody employed for treating relapsed/refractory multiple myeloma and light-chain amyloidosis. Quantifying monoclonal antibodies in serum presents challenges due to interference from biological matrices. This research aimed to develop and verify an liquid chromatography tandem-mass spectrometry (LC-MS/MS) approach for quantifying serum daratumumab, employing immunoglobulin G purification without alkylation, and to assess its applicability in patients with multiple myeloma receiving intravenous daratumumab.

Anterior capsulotomy and accumbensotomy of obsessive-compulsive disorder with obsessional slowness: a case report.

Unlabelled: Obsessional slowness (OS) is characterized by a syndrome of extreme slowness in doing ordinary, day-to-day activities. Several scholars regarded OS as secondary to obsessive compulsive disorder (OCD). Therefore, it is commonly thought to be the consequence of extensive rituals and has been paid minimal attention in its own right.

Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin.

Background: Obstructed defecation syndrome (ODS) represents the most prevalent form of chronic constipation, affecting a diverse patient population, leading to numerous complications, and imposing a significant burden on healthcare resources. Most ODS patients have insufficient rectal propulsion, but the exact mechanism underlying the pathogenesis of ODS remains unclear.

Aim: To explore the molecular mechanism underlying the pathogenesis of ODS.