Advances in A-to-I RNA editing in cancer.

RNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers. One of the most prevalent forms of RNA modifications in humans is adenosine-to-inosine (A-to-I) editing, catalyzed by the enzyme adenosine deaminase acting on RNA (ADAR) in double-stranded RNA (dsRNA).

Bisphenol S exposure interrupted human embryonic stem cell derived cardiomyocytes differentiation through ER-NF-κB/ERK signaling pathway.

Bisphenol S (BPS) has been put into production as a wide range of Bisphenol A (BPA) alternatives, while little is known regarding its cardiac developmental toxicity. To explore the effect of BPS on cardiomyocyte differentiation and its mechanism, our study established the human embryonic stem cell-cardiomyocyte differentiation model (hESC-CM), which was divided into early period of differentiation (DP1:1-8d), anaphase period of differentiation (DP2:9-16d) and whole stage of differentiation (DP3:1-16d) exposed to human-related levels of BPS. We found that the survival rate of cardiomyocytes was more sensitive to BPS at the early stage of differentiation than at the anaphase stage of differentiation, and exposure to higher than 30 µg/mL BPS throughout the differentiation period decreased the expression of cTnT.

Efficient electrochemiluminescence sensor utilizing Zr-PyTCPPMOF for swift hydrogen sulfide detection.

The ultrahigh-sensitive detection of HS is reported using a novel dual-ligand metal-organic framework (MOF) electrochemiluminescence (ECL) sensor. By combining tetrakis(4-carboxyphenyl) porphyrin (TCPP) and 1,3,6,8-tetrakis(4-carboxyphenyl) pyrene (TBAPy) as ligands and employing zirconium as the metal source, a spindle-shaped Zr-PyTCPPMOF was successfully designed and synthesized. Notably, the multiple nitrogen structures of porphyrin provided abundant binding sites for sulfur (S), further enhancing the ECL signal of Zr-PyTCPPMOF.

Pyrotinib Plus Taxanes or Vinorelbine for the Treatment of Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: Prospective Evaluation of Efficacy and Safety.

Purpose: The clinical benefits of pyrotinib plus taxanes or vinorelbine have not been studied systemically. Consequently, we conducted a prospective evaluation to assess the efficacy and safety of pyrotinib plus taxanes or vinorelbine in patients with human epidermal growth factor 2 (HER2)-positive metastatic breast cancer (MBC).

Methods: Patients with HER2-positive MBC were included to receive pyrotinib combined with taxanes or vinorelbine in Jiangsu Cancer Hospital.

[Spatial-temporal Variations and Driving Factors Analysis of Total Nitrogen Concentration in the Haihe River Basin from 2018 to 2022].

The Beijing-Tianjin-Hebei （Jing-Jin-Ji） Region is home to the most acute economic, resource, and environmental conflicts in the Bohai Sea region, and the rivers entering the sea carry abundant total nitrogen （TN） input into the Bohai Bay, which is the main land-based input causing eutrophication of the bay. The Haihe River Basin in the Jing-Jin-Ji Region was divided into 112 （2018-2019） and 187 （2020-2022） control units, and the spatial and temporal variations in TN concentration in the surface water of the Haihe River Basin in the Jing-Jin-Ji Region were systematically analyzed from 2018 to 2022 by combining the Euclidean distance analysis method and the K-means clustering analysis method. The results showed that the annual average concentration of TN in the region showed a trend of decreasing （2018-2020） and then increasing （2021-2022）, in which the concentration of TN increased significantly from June 2021 to June 2022.

Hyperglycemia Inhibits AAA Expansion: Examining the Role of Lysyl Oxidase.

Abdominal aortic aneurysm (AAA) is a common, progressive and potentially fatal dilation of the most distal aortic segment. Multiple studies with longitudinal follow-up of AAA have identified markedly slower progression among patients affected with diabetes. Understanding the molecular pathway responsible for the growth inhibition could have implications for therapy in nondiabetic AAA patients.

Associations between phthalate metabolites and body composition in children aged 8-19 years.

This study aimed to determine the relationship between individual and combined phthalate metabolites and body composition in children and adolescents using data from the 2015-2018 National Health and Nutrition Examination Survey. Single-exposure analysis indicated that most phthalate metabolites were negatively correlated with areal bone mineral density (aBMD). Quantile g-computation demonstrated a negative relationship between the mixture of phthalate metabolites and aBMD, which was confirmed by the Bayesian kernel machine regression model.

Unraveling the Impact of Stabilizers on Nanocrystal Preparation and Oral Absorption: A Case Study of Poorly Soluble Andrographolide.

Drug nanocrystal engineering is an attractive pharmaceutical approach to enhancing the oral bioavailability of poorly soluble drugs. The mechanism of drug nanocrystal stabilization, however, is unclear. Here we developed andrographolide nanocrystals (AG-NCs) with various nonionic surfactants (Pluronic-F127, TPGS, or Brij-S20).

MOF derived cobalt ferrite cubic rod-like materials for highly efficient electrochemical simultaneous detection of multiple heavy metal ions.

A series of CoFe2O4 materials derived from metal-organic framework were successfully constructed by the solvent-thermal method. The morphology of a typical sample CoFe2O4-1 was mostly in the form of a cubic rod-like structure with a size distribution of 3.2 ± 0.

Progress and Gaps in Respiratory Disease Research and Treatment: Highlights of the IRM 2024 in Shanghai.

Respiratory diseases pose a major public health challenge globally, necessitating collaborative efforts between basic researchers and clinicians for effective solutions. China, which is heavily impacted by a broad spectrum of respiratory disorders, has made notable strides in both research and clinical management of these diseases. The International Respiratory Medicine (IRM) meeting was organized with the primary goal of facilitating the exchange of recent research developments and promoting collaboration between Chinese and American scientists in both basic and clinical research fields.

The Antagonism Hypothesis: A New View on the Emergence of Consciousness.

Purpose: The generation of consciousness poses a complex scientific challenge. Neuroscience and biological sciences have extensively studied this phenomenon, yielding numerous theories and hypotheses. However, to date, no reliable evidence has emerged to exclude any hypothesis conclusively, nor has any theory garnered unanimous agreement.

Gbp2 driving macrophages dynamics in murine heart transplant.

Background And Objective: Organ transplantation is a vital treatment for patients with end-stage organ diseases, and macrophages play a key role in the rejection process. This study seeks to pinpoint key genes responsible for the dynamic changes in macrophages during rejection and to evaluate their impact on macrophage polarization through bioinformatics analysis.

Methods: We selected single-cell sequencing data of mouse heart transplant models from Genome Sequence Archive to construct a dynamic landscape of immune cells during acute rejection.

Gouty arthritis patients' diagnostic, biochemical, and hematological characteristics study: a single-center retrospective study.

Objective: This study aims to investigate the diagnostic, biochemical, and hematological characteristics of patients with gouty arthritis and analyze their correlations with baseline characteristics to guide clinical practice, develop personalized treatment strategies, and improve patient outcomes.

Methods: A single-center retrospective analysis was conducted on 8,344 patients with acute gouty arthritis admitted to our hospital between January 2014 and December 2023. Baseline characteristics and laboratory data, including uric acid, blood glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP), C-reactive protein (CRP), white blood cell count, neutrophil count, lymphocyte count, monocyte count, fibrinogen, and serum albumin, were collected.

Bioactivity Profiling of Chemical Mixtures for Hazard Characterization.

The assessment and regulation of chemical toxicity to protect human health and the environment are done one chemical at a time and seldom at environmentally relevant concentrations. However, chemicals are found in the environment as mixtures, and their toxicity is largely unknown. Understanding the hazard posed by chemicals within the mixture is critical to enforce protective measures.

Impact of SGLT2 inhibitors on cardiovascular outcomes and metabolic events in Chinese han patients with chronic heart failure.

Objective: This study aimed to evaluate the real-world impact of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on the efficacy, safety, and metabolic profiles of patients with chronic heart failure (CHF), both with and without type 2 diabetes mellitus (T2DM).

Methods: A cohort of 1,130 patients with reduced ejection fraction chronic heart failure (HFrEF) was recruited from Zhongnan Hospital of Wuhan University, spanning January 2021 to August 2023. Among these, 154 patients received SGLT2i therapy, while 131 patients were assigned to a non-SGLT2i group, following specified inclusion and exclusion criteria.

Node Classification Method Based on Hierarchical Hypergraph Neural Network.

Hypergraph neural networks have gained widespread attention due to their effectiveness in handling graph-structured data with complex relationships and multi-dimensional interactions. However, existing hypergraph neural network models mainly rely on planar message-passing mechanisms, which have limitations: (i) low efficiency in encoding long-distance information; (ii) underutilization of high-order neighborhood features, aggregating information only on the edges of the original graph. This paper proposes an innovative hierarchical hypergraph neural network (HCHG) to address these issues.

The microRNA-29ab1/Zfp36/AR Axis in the Hypothalamus Regulates Male-Typical Behaviors in Mice.

Male-typical behaviors such as aggression and mating, which reflect sexual libido in male mice, are regulated by the hypothalamus, a crucial part of the nervous system. Previous studies have demonstrated that microRNAs (miRNAs), especially , play a vital role in reproduction and the neural control of behaviors. However, it remains unclear whether affects reproduction through the hypothalamus-mediated regulation of male-typical behaviors.

Disulfiram in liver diseases: a double-edged sword.

Disulfiram, a synthetic drug, has historically played a significant role in the treatment of alcoholic liver disease as the first medication approved by the U.S. Food and Drug Administration for alcohol use disorders.

Polycyclic aromatic hydrocarbons exposure in early pregnancy on child neurodevelopment.

The epidemiological evidence from studies on the impact of exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy on child neurodevelopment is inconclusive. This study aimed to assess the associations of PAHs exposure in early pregnancy and neurodevelopmental outcomes in children aged 6-12 months in a prospective cohort. In this study, we included 172 mother-child pairs with complete data in Tianjin City, China.

Polydopamine functionalized TiO with N doping, oxygen vacancies, and carbon layers for enhanced photoelectrocatalytic performance.

The development of a photoelectrode featuring both excellent reusability and a simple preparation process remains exceptionally challenging for TiO-based photoelectrocatalytic technology. Herein, a three-dimensional photoelectrode with N doping, oxygen vacancies (O), and carbon layers (NTC) was prepared via the "carbothermal reduction-pressing-calcination" method. The photoelectrode degraded 97.

A Lipiodol Pickering Emulsion Stabilized by Iron-Doped Carbon Nanozymes for Liver Transarterial Chemoembolization.

Transarterial chemoembolization (TACE) utilizing a water-in-oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the efficiency of TACE. Herein, a novel lobaplatin-loaded lipiodol emulsion (denoted as ICN-LPE) is developed by constructing a lipiodol Pickering emulsion (LPE) stabilized with iron-doped carbon nanozymes (ICN) to mitigate the issue of lipiodol-water separation.

Establishment and bioinformatics analysis of a four-miRNA prognostic signature for pleural mesothelioma.

Pleural mesothelioma (PM), an uncommon yet highly aggressive malignant neoplasm, has a very poor prognosis with a median survival of less than one year after diagnosis, morbidity and mortality due to PM are on the rise year by year worldwide. Our research aims to utilize molecular characteristics and microRNAs (miRNAs) as a breakthrough in predicting the survival of PM patients, hoping to find a molecular mechanism that can predict the survival of PM patients. The miRNA expression profiles and corresponding clinical information of patients with PM were obtained from The Cancer Genome Atlas (TCGA) database, a miRNA-based prognostic signature was developed using Cox regression analysis in the training cohort, which was validated in the testing cohort and complete cohort.

Tailoring microbial fitness through computational steering and CRISPRi-driven robustness regulation.

The widespread application of genetically modified microorganisms (GMMs) across diverse sectors underscores the pressing need for robust strategies to mitigate the risks associated with their potential uncontrolled escape. This study merges computational modeling with CRISPR interference (CRISPRi) to refine GMM metabolic robustness. Utilizing ensemble modeling, we achieved high-throughput in silico screening for enzymatic targets susceptible to expression alterations.

Ultrathin Bioelectrode Array with Improved Electrochemical Performance for Electrophysiological Sensing and Modulation.

To achieve high accuracy and effectiveness in sensing and modulating neural activity, efficient charge-transfer biointerfaces and a high spatiotemporal resolution are required. Ultrathin bioelectrode arrays exhibiting mechanical compliance with biological tissues offer such biointerfaces. However, their thinness often leads to a lack of mechano-electrical stability or sufficiently high electrochemical capacitance, thus deteriorating their overall performance.