Global Gac/Rsm regulatory system activates the biosynthesis of mupirocin by controlling the MupR/I quorum sensing system in sp. NCIMB 10586.

The biosynthesis of mupirocin, a clinically significant antibiotic produced by sp. NCIMB 10586, is activated by the -acyl homoserine lactone (AHL) MupR/I quorum sensing (QS) system. However, to date, limited research has focused on the influence of global regulators such as the GacS/A two-component system (TCS) on the MupR/I QS system or mupirocin biosynthesis.

Prevalence of malnutrition among adult inpatients in China: a nationwide cross-sectional study.

Malnutrition substantially contributes to adverse clinical outcomes. However, no national survey has been conducted to characterize its epidemiology in hospital settings in China. We conducted the China Nutrition Fundamental Data 2020 project among a multistage stratified cluster sample of adult inpatients from 291 study sites across 30 provinces, autonomous regions and municipalities (except for Hong Kong, Macao, Taiwan Province, and the Xizang Autonomous Region, please see MATERIALS AND METHODS for details of the causes) of China to generate reliable data on the prevalence of malnutrition and explore the associated risk factors.

Photothermal nanofiber-mediated photoporation for gentle and efficient intracellular delivery of macromolecules.

Photoporation with free photothermal nanoparticles (NPs) is a promising technology for gentle delivery of functional biomacromolecules into living cells, offering great flexibility in terms of cell types and payload molecules. However, the translational use of photoporation, such as for transfecting patient-derived cells for cell therapies, is hampered by safety and regulatory concerns as it relies on direct contact between cells and photothermal NPs. A solution is to embed the photothermal NPs in electrospun nanofibers, which form a substrate for cell culture.

Efficacy of Nebulized Budesonide and Systemic Corticosteroids During Hospitalization on All-Cause Mortality in AECOPD Patients: A Real-World Study.

Background: Guidelines specify steroids as therapy for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the duration of survival benefit associated with steroids and the optimal dosage of nebulized budesonide (NB) during hospitalization remain unclear.

Methods: We conducted a retrospective study of hospitalized AECOPD patients.

The First Molecular Ferroelectric Mott Insulator.

With the discovery of colossal magnetoresistance materials and high-temperature superconductors, Mott insulators can potentially undergo a transition from insulating state to metallic state. Here, in molecular ferroelectrics system, a Mott insulator of (CHN)VO has been first synthesized, which is a 2D organic-inorganic ferroelectric with composition of layered vanadium oxide and quinuclidine ring. Interestingly, accompanied by the ferroelectric phase transition, (CHN)VO changes sharply in conductivity.

LINC01305 and LAD1 Co-Regulate CTTN and N-WASP Phosphorylation, Mediating Cytoskeletal Reorganization to Promote ESCC Metastasis.

Esophageal squamous cell carcinoma (ESCC) is prone to metastasis and is a leading cause of mortality. The cytoskeleton is closely related to cell morphology and movement; however, little research has been conducted on ESCC metastasis. In this study, we found that the anchoring filament protein ladinin 1 (LAD1) specifically binds to LINC01305 for co-regulating the level of modulating cortactin proteins (CTTN) and neuronal Wiskott-Aldrich syndrome protein (N-WASP) phosphorylation, which mediates cytoskeletal reorganization and affects the metastasis of ESCC cells.

Phonon thermal transport in BiTe/SbTe monolayer superlattices: a neural network potential study.

Superlattices are significant means to reduce the lattice thermal conductivity of thermoelectric materials and optimize their performance. In this work, using high-precision first-principles based neural network potentials combined with non-equilibrium molecular dynamics simulations and the phonon Boltzmann transport equation, the lattice thermal conductivities of BiTe monolayer and lateral BiTe/SbTe monolayer superlattices are thoroughly investigated. As the period length increases, the thermal conductivity shows a trend of an initial decrease followed by an increase, which aligns with conventional observations.

Molecular ferroelectric self-assembled interlayer for efficient perovskite solar cells.

The interfacial molecular dipole enhances the photovoltaic performance of perovskite solar cells (PSCs) by facilitating improved charge extraction. However, conventional self-assembled monolayers (SAMs) face challenges like inadequate interface coverage and weak dipole interactions. Herein, we develop a strategy using a self-assembled ferroelectric layer to modify the interfacial properties of PSCs.

Integrating network pharmacology and experimental verification to reveal the ferroptosis-associated mechanism of Changpu-Yizhi-Wan in the treatment of Alzheimer's disease.

To explore the pharmacological mechanism of Changpu-Yizhi-Wan (CYW) in the treatment of Alzheimer's disease (AD) from the perspective of ferroptosis based on network pharmacology and experimental verification. The Encyclopedia of Traditional Chinese Medicine 2.0 (ETCM2.

Molecular Ferroelectrics for Highly Sensitive Detection Toward Low-Frequency Sound Recognition.

Human hearing cannot sensitively detect sounds below 100 Hz, which can affect the physical well-being and lead to dizziness, headaches, and nausea. Piezoelectric acoustic sensors still lack sensitivity to low-frequency sounds owing to the low piezoelectric coefficient or high elastic modulus of materials. The low elastic modulus and substantial piezoelectric coefficient of molecular ferroelectric materials make them excellent candidates for acoustic sensors.

Genomic insights into the specialisation and selection of the Jinding duck.

The domestication of ducks represents a pivotal evolutionary shift from the unguided propagation of wild species to deliberate human-mediated selection, culminating in distinct behavioural, morphological, and physiological traits that differentiate domesticated ducks from their wild counterparts. This transition has yielded breeds with traits fine-tuned to specific economic roles, such as egg production, meat yield, or dual-purpose functionality. Duck domestication plays a significant role in poultry production globally, meeting the growing demand for eggs and meat in various regions.

Effect of providing at-home opioid disposal kits at discharge after an orthopaedic surgery.

Prescription opioids after surgery may pose a risk if left unused. However, prescribers rely on their best judgement in determining how much their patients need, often resulting in over-prescription of these medications. Opioid disposal is a strategy to reduce the risk of persistent use or misuse of opioids.

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults.

Purpose: To investigate the 10-year changes in visual function and incidence of visual impairment (VI) in highly myopic eyes.

Methods: This longitudinal study enrolled highly myopic individuals who were followed up for 10 years. All participants underwent detailed ophthalmic examinations at baseline and follow-up visits.

Application of additive manufacturing TaBw01 porous tantalum rod in ARCO stage II osteonecrosis of the femoral head.

Purpose: This study aims to investigate the suitable surgical strategies for applying TaBw01 porous tantalum rod across different stages of osteonecrosis of the femoral head (ONFH).

Methods: TaBw01 tantalum rods were fabricated using type FTaY-1 tantalum powder via the foam impregnation-sintering method. Mechanical testing with the Instron 8801 universal testing machine and finite element analysis (FEA) assessed single tantalum rod implantation and impaction bone grafting combined with rod implantation.

CpG islands: Features and distribution in the genomes of porcine parvovirus.

Porcine parvovirus disease is a reproductive disorder caused by the porcine parvovirus (PPV) in sows and is characterised by miscarriage, stillbirth and mummification in pregnant sows. Porcine parvovirus disease poses a significant threat to pork herds and seriously hinders healthy and sustainable development of the pig farming industry. Currently, there is no effective treatment for porcine parvovirus disease except for prevention and control measures.

The mediating role of rumination in the relationship between negative cognitive styles and depression among pregnant women in Guangzhou, China.

Backgrounds: Negative cognitive styles (NCSs) have been identified as risk factor for the onset of depression. However, little empirical evidence is available to support its role in psychological disorders in the perinatal period. Moreover, less is known about the underlying mechanism in the relation between NCSs and depression in pregnant women.

EYE SHAPE DEFORMITY PREDICTS MYOPIC MACULOPATHY PROGRESSION AMONG HIGHLY MYOPIC INDIVIDUALS: A 4-Year Longitudinal Study.

Purpose: To determine the impact of eye shape using three-dimensional magnetic resonance imaging on myopic maculopathy (MM) progression.

Methods: At baseline, 67 participants with high myopia were selected. Eye shape was classified into spheroidal, ellipsoidal, temporally distorted, nasally distorted, conical, and barrel-shape identified from three-dimensional magnetic resonance imaging.

Rural residents' Knowledge, Attitude, and Practice in relation to infection risk during the late stage of an epidemic: a cross-sectional study of COVID-19.

Background: In the field of public health, the prevention and management of infectious diseases in rural regions have always been crucial. This study aims to analyze the factors influencing rural residents' Knowledge, Attitude, and Practices and their correlation with infection risk during the late stage of an epidemic, with a focus on the COVID-19 case.

Methods: A cross-sectional study was conducted in rural regions of China's Guangdong province, using a multi-stage sampling technique to select rural residents for a validated questionnaire survey in February 2023.

Resveratrol and Its Analogues: Anti-ageing Effects and Underlying Mechanisms.

Ageing is a natural process accompanied by functional and structural decline of diverse tissues and organs, which could cause susceptibility to various diseases and death. The anti-ageing interventions have aroused huge research interest with the rapid rise of ageing population in the world. Resveratrol, a polyphenolic stilbene, could be naturally isolated from various plants, such as grapes, blueberries, and peanuts.

Plasma CircCYP24A1 as a Novel Biomarker of Esophageal Squamous Cell Carcinoma.

Background: A clinical challenge in esophageal squamous cell carcinoma (ESCC) remains the lack of applicable plasma biomarkers for screening and diagnosis. Circular RNAs (circRNAs) hold great potential as biomarkers for cancer. The study aims to explore a circRNA as a potential plasma biomarker for screening strategies and diagnostic approaches to ESCC.

A New Heavy-Duty Bearing Degradation Evaluation Method with Multi-Domain Features.

Under heavy load conditions, bearings are subjected to non-uniform and frequently changing loads, which leads to randomness in the spatial distribution of bearing degradation characteristics. Aiming at the problem that the traditional degradation index cannot accurately reflect the degradation state of heavy-duty bearings in the whole life cycle, a new degradation evaluation method based on multi-domain features is proposed in this paper, which aims to capture the early degradation point of heavy-duty bearings and characterize their degradation trend. Firstly, the energy entropy feature is obtained by improving the wavelet packet decomposition, and the original multi-domain feature set is constructed by combining the time domain and frequency domain features.

Genome-Wide Identification and Characterization of the Laccase Gene Family in and Its Potential Roles in Response to Salt and Drought Stresses.

Laccase (, EC 1.10.3.