Abnormal Ventral Somatomotor Network Homogeneity in Patients With Temporal Lobe Epilepsy.

Background: Abnormalities of functional connectivity in the somatomotor network have been thought to play an essential role in the pathophysiology of epilepsy. However, there has been no network homogeneity (NH) study about the ventral somatomotor network (VSN) in patients with temporal lobe epilepsy (TLE). Therefore, we explored the NH of the VSN in TLE patients in this study.

The combination treatment strategy of lenvatinib for hepatocellular carcinoma: a real-world study.

Purpose: Lenvatinib is recommended as a first-line therapy in unresectable hepatocellular carcinoma (HCC). Combination therapy with local therapy (LT) or PD-1/PD-L1 inhibitors (PI) might improve the antitumor effect of lenvatinib. The objective of this study was to investigate the antitumor effect of lenvatinib-based combination therapies.

SWOLLEN TAPETUM AND STERILITY 1 is required for tapetum degeneration and pollen wall formation in rice.

The pollen wall is important for protecting the male gametophyte and for fertilization. The lipid components of the pollen wall are mainly synthesized and transported from the sporophytic tapetum. Although several factors related to lipid biosynthesis have been characterized, the molecular mechanisms underlying lipid biosynthesis during pollen development in rice (Oryza sativa L.

Ammonium continuous removal by zeolite P synthesized using fly ash combined with bacteria in aqueous solution.

The new composite product synthesized by zeolite P and bacteria consisting of nitrobacteria and denitrobacteria can efficiently and continuously remove ammonium in solution through zeolite adsorption and bacteria degradation. In this study, we used fly ash to prepared zeolite P, and then combined bacteria to synthesize the composite product. The adsorption efficiency and mechanism of products for ammonium were further studied by batch and dynamic experiments, and adsorption model.

Building a novel multivariate nonlinear MGM(1,,|) model to forecast carbon emissions.

With the proposal of the carbon neutrality target, China's attention to carbon emissions has been further enhanced. Effective prediction of future carbon emissions is important for the formulation of carbon neutralization target and action plans in the region. Many factors affecting carbon emissions, cause their development trends may be nonlinear.

IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance.

Objective: To investigate the effect of IL-27 on Th9 differentiation and Th1/Th2 balance.

Methods: C57BL/6 (B6) mice were treated with ovalbumin to establish an allergic asthma (AA) model and subjected to IL-27 overexpression (OV) and empty vector (EV). Hematoxylin-eosin (HE) staining was performed to observe lung tissue inflammation.

Predictive effect of Bayes discrimination in the level of serum protein factors and cognitive dysfunction in schizophrenia.

Finding molecular biomarkers that can be related to the degree of cognitive dysfunction in schizophrenia remains a challenge. The levels of 6 Serum Protein Factors (NGF, BDNF, IL-6, TNF-α, S100β, GFAP) in peripheral blood of patients with schizophrenia were measured. The cognitive function of patients with schizophrenia was assessed by MATRICS Consensus Cognitive Battery (MCCB), a systematic assessment tool of international gold standard for cognitive function assessment of schizophrenia.

Construction of Talent Competency Model for Senior Care Professionals in Intelligent Institutions.

As the problem of the aging population becomes more and more serious, building an intelligent senior care service model and optimizing the senior care service industry become key to the development of the senior care service industry. The key to developing intelligent senior care services is to improve the overall senior care personnel quality and construct a competency model of intelligent institutional senior care professionals. This study used literature research and interviews to establish 31 relevant institutional senior care professional talent competency elements.

High-Rate, Large Capacity, and Long Life Dendrite-Free Zn Metal Anode Enabled by Trifunctional Electrolyte Additive with a Wide Temperature Range.

Aqueous Zn-ion batteries (AZIBs) have been recognized as promising energy storage devices due to their high theoretical energy density and cost-effectiveness. However, side reactions and Zn dendrite generation during cycling limit their practical application. Herein, ammonium acetate (CH COONH ) is selected as a trifunctional electrolyte additive to enhance the electrochemical performance of AZIBs.

Transparent nanocrystal-in-glass composite fibers for multifunctional temperature and pressure sensing.

The pursuit of compact and integrated devices has stimulated a growing demand for multifunctional sensors with rapid and accurate responses to various physical parameters, either separately or simultaneously. Fluorescent fiber sensors have the advantages of robust stability, light weight, and compact geometry, enabling real-time and noninvasive signal detection by monitoring the fluorescence parameters. Despite substantial progress in fluorescence sensors, achieving multifunctional sensing in a single optical fiber remains challenging.

Ultrafast Synthesis of Layered Transition-Metal Oxide Cathodes from Metal-Organic Frameworks for High-Capacity Sodium-Ion Batteries.

Layered transition-metal oxides are promising candidate cathode materials for sodium-ion batteries due to their abundant raw materials and high theoretical capacity. Nevertheless, a long-time high-temperature heat treatment is required in traditional preparation methods, leading to low synthesis efficiency and waste of energy. Herein, an ultrafast preparation method of layered transition-metal oxides was proposed through minute calcination of metal-organic frameworks (MOFs).

pH Stimuli-Responsive, Rapidly Self-healable Coatings Enhanced the Corrosion Resistance and Osteogenic Differentiation of Mg-1Ca Osteoimplant.

Mg-Ca alloys have emerged as a promising research direction for biomedical implants in the orthopedic field. However, their clinical use is deterred by their fast corrosion rate. In this work, a pH stimuli-responsive silk-halloysite (HNT)/phytic acid (PA) self-healing coating (Silk-HNT/PA) is constructed to slow down the corrosion rate of Mg-1Ca alloy and its cell viability and osteogenic differentiation ability are enhanced.

Systematic Screening of Chemical Constituents in the Traditional Chinese Medicine by UHPLC-Q-Exactive Orbitrap Mass Spectrometry.

(dried root of (Royle) Johnst.) has been used in traditional Chinese medicine (TCM) to treat macular eruptions, measles, sore throat, carbuncles, burns, skin ulcers, and inflammation. Previous studies have shown that shikonins and shikonofurans are two of their main bioactive ingredients.

Detection of multiple human astroviruses in sewage by next generation sequencing.

Human astrovirus (HAstV) composes of classic HAstV serotypes 1-8 and recently discovered novel HAstV-MLB and HAstV-VA strains. A number of studies have demonstrated that wastewater analysis is an effective approach to understand the prevalence and diversity of enteric viruses in local population. However, a comprehensive analysis of classic and novel HAstVs in sewage is still lacking.

Extended Reality (XR) and telehealth interventions for children or adolescents with autism spectrum disorder: Systematic review of qualitative and quantitative studies.

World Health Organization reported that almost one in 100 children is diagnosed with autism spectrum disorder (ASD) worldwide. Extended Reality (XR) and Telehealth interventions are evident to be effective for ASD treatments. While there is no comprehensive systematic review to summarize and evaluate the evidence for promoting the accessibility of different technology-based treatment regiments.

LF-NMR/MRI Determination of Different 6-Benzylaminopurine Concentrations and Their Effects on Soybean Moisture.

In this study, we aimed to clarify the distribution and dynamics of water in the Xudou 20 soybean cultivar post-germination after culturing plants with various concentrations of 6-benzylaminopurine (6-BA). Low-field nuclear magnetic resonance and magnetic resonance imaging (LF-NMR/MRI), as well as principal component analysis (PCA), were used for the investigation. Results showed that low concentrations of 6-BA promoted soybean germination and high concentrations inhibited soybean germination, with 5 mg/l of 6-BA producing the most optimal conditions for growth.

Using health administrative data to identify patients with pulmonary hypertension: A single center, proof of concept validation study in Ontario, Canada.

Real-world identification of pulmonary hypertension (PH) is largely based on the use of administrative databases identified by ICD codes. This approach has not been validated. The aim of this study was to validate a diagnosis of PH and its comorbidities using ICD 9/10 codes.

The Prevalence of Irritable Bowel Syndrome Among Chinese University Students: A Systematic Review and Meta-Analysis.

Background: Irritable bowel syndrome (IBS) has become a common public health issue among university students, impairing their physical and mental health. This meta-analysis aimed to examine the pooled prevalence of IBS and its associated factors among Chinese university students.

Methods: Databases of PubMed, EMBASE, MEDLINE ( EBSCO), CINAHL ( EBSCO), Wan Fang, CNKI and Weipu ( VIP) were systematically searched from inception date to May 31, 2021.

Forecasting carbon emissions using MGM(1,m|λ,γ) model with the similar meteorological condition.

Carbon emission is a common concern of the international community and effectively predicting its future trend is necessary for emission reduction planning. Considering that the change trend of carbon emissions is unstable, more attention should be paid to the correction effect of new information on the development trend. Therefore, based on the traditional MGM(1,m) model, this paper introduces the new information priority operator λ and nonlinear parameter γ to strengthen the role of new information, further constructs three comparison models of MGM(1,m|λ), MGM(1,m|γ) and MGM(1,m|λ,γ).

DEAP1 encodes a fasciclin-like arabinogalactan protein required for male fertility in rice.

Arabinogalactan proteins (AGPs) are widely distributed in plant cells. Fasciclin-like AGPs (FLAs) belong to a subclass of AGPs that play important roles in plant growth and development. However, little is known about the biological functions of rice FLA.

Monitoring cardiovascular disease severity using near-infrared mechanoluminescent materials as a built-in indicator.

Artificial vascular grafts (AVGs) are widely used to treat cardiovascular diseases (CVDs). But none of the reported AVGs can also monitor the CVD severity. Because CVDs affect the blood pressure, we proposed to employ a force-sensing material that emits near-infrared (NIR) light upon force loading, a NIR mechanoluminescent (ML) material (CaZnOS:Nd), as an indicator in AVGs to tackle this challenge.

Docosahexaenoic acid supplementation represses the early immune response against murine cytomegalovirus but enhances NK cell effector function.

Background: Docosahexaenoic acid (DHA) supplementation is beneficial for several chronic diseases; however, its effect on immune regulation is still debated. Given the prevalence of cytomegalovirus (CMV) infection and because natural killer (NK) cells are a component of innate immunity critical for controlling CMV infection, the current study explored the effect of a DHA-enriched diet on susceptibility to murine (M) CMV infection and the NK cell effector response to MCMV infection.

Results: Male C57BL/6 mice fed a control or DHA-enriched diet for 3 weeks were infected with MCMV and sacrificed at the indicated time points postinfection.

Comparative study on molecular epidemiology of measles H1 outbreak and sporadic cases in Shandong Province, 2013-2019.

Background: Measles caused by measles virus (MeV) is a highly contagious viral disease which has also been associated with complications including pneumonia, myocarditis, encephalitis, and subacute sclerosing panencephalitis. The current study isolated 33 strains belonging to 2 groups, outbreak and sporadic strains, in 13 cities of Shandong province, China from 2013 to 2019. Comparison of genetic characterization among 15 outbreak strains and 18 sporadic strains was performed by analyzing nucleotide sequences of the C-terminal region of N protein gene (N-450).

Abnormal global alternative RNA splicing in COVID-19 patients.

Viral infections can alter host transcriptomes by manipulating host splicing machinery. Despite intensive transcriptomic studies on SARS-CoV-2, a systematic analysis of alternative splicing (AS) in severe COVID-19 patients remains largely elusive. Here we integrated proteomic and transcriptomic sequencing data to study AS changes in COVID-19 patients.