Exploration of high-value pathways for lignin: From catalyst preparation to product development.

Considering the facts of fossil fuel depletion and environmental issues, the conversion of biomass into high value-added chemicals is of great importance. In this work, Ni and Co were encapsulated in lignin-derived phenolic resin spheres to obtain NiCo@LRS, which was then employed as a sacrificial template for the synthesis of the bimetallic catalyst NiCo@LC-RS. The Ni and Co act as the acid and dehydrogenation sites for the catalytic transfer hydrogenolysis of 2-phenoxy-1-phenylethanol (pp-ol) and corncob lignin, respectively, and exhibit a synergistic enhancement effect.

Genome-Wide Exploration and Characterization of the Gene Family's Expression Patterns in Response to Abiotic Stresses in Siberian Wildrye ( L.).

Siberian wildrye ( L.), a model Gramineae plant, has high eco-economic value but limited seed and forage yield. transcription factors are widely regarded as influencing yield and quality and being crucial for growth and development; still, this gene family in Siberian wildrye remains unexplored.

Multi-target microfluidic loop-mediated isothermal amplification technology for the detection of foodborne pathogens in various food matrices.

Background: Nutritional foods are susceptible to foodborne pathogens. Loop-mediated isothermal amplification (LAMP) technology has great potential in detecting foodborne pathogens, but conventional LAMP suffers from drawbacks such as complex operation and low detection throughput. Therefore, there is an urgent need to develop a multi-targeted and simultaneous LAMP detection platform to identify pathogens across various food matrices, in order to effectively manage food quality and safeguard human health.

Corrigendum: Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome.

[This corrects the article DOI: 10.3389/fendo.2023.

[Therapeutic Effect of Cang-Ai Volatile Oil on High-Altitude Rats With Cardiac Hypertrophy Through Modulation of Oxidative Stress Response].

Objective: To explore the therapeutic effect of Cang-ai volatile oil (CAVO) on rats with myocardial hypertrophy (MH) exposed to the hypobaric hypoxic environment of the Qinghai-Tibet Plateau using 7.0-tesla (7.0T) cardiac magnetic resonance imaging (CMR).

STK11 genetic alterations in metastatic EGFR mutant lung cancer.

This study was conducted to investigate the relationship between STK11 genetic alterations and the outcomes of patients with metastatic EGFR mutant lung cancer. Clinical characteristics and genomic data were downloaded from the cBioPortal database. The information of the case with STK11 mutation was collected from Jiangyin People's Hospital.

One lung ventilation during thoracoscopic lobectomy alters lung microbiome miversity and composition.

Current research indicates that the lungs are not sterile and maintain their own unique microecological balance, which can be disrupted by mechanical ventilation.One-lung ventilation (OLV) induces ischemia-reperfusion (IR) injury in the non-ventilated lung, a common contributor to acute lung injury during the perioperative period. This study investigates alterations in the pulmonary microbiome following one-lung ventilation during thoracoscopic lobectomy and evaluates the impact of differential microbiota on inflammatory responses.

Efficacy comparison of optimal natural orifice specimen extraction for robotic middle rectal cancer resection in women: transanal or transvaginal orifice.

Purpose: This study aimed to determine the optimal natural orifice specimen extraction (NOSE) method for robotic-assisted mid-rectal cancer resection in women.

Methods: This retrospective propensity score-matched (PSM) study was to analyze the clinical data prospectively collected from female rectal cancer patients who underwent either robotic-assisted transvaginal specimen extraction (RATV) or robotic-assisted transanal specimen extraction (RATA) at our center between June 2016 and December 2022. The main outcome measures were urinary, anal, and sexual function.

Palmitic acid induces cardiomyocyte apoptosis by enhancing the KLF4/cMLCK signaling pathway.

Hyperlipidemia and myocardial apoptosis caused by myocardial ischemia are the main causes of high mortality rates in cardiovascular diseases. Previous studies have indicated that Krüppel-like factor 4 (KLF4) is involved in the induction of cardiac myocyte apoptosis under various stress conditions. In current study, we discovered that KLF4 also participates in palmitic acid (PA)-induced cardiac myocyte apoptosis.

Bile acid sequestrant inhibits gluconeogenesis via inducing hepatic cysteine dioxygenase type 1 to reduce cysteine availability.

Bile acid sequestrants such as cholestyramine (ChTM) are gut-restricted bile acid-binding resins that block intestine bile acid absorption and attenuate hepatic bile acid signaling. Bile acid sequestrants induce hepatic bile acid synthesis to promote cholesterol catabolism and are cholesterol-lowering drugs. Bile acid sequestrants also reduce blood glucose in clinical trials and are approved drugs for treating hyperglycemia in type-2 diabetes.

Genome-Wide Identification and Expression Profiling of the Transcription Factor Family in Response to Abiotic Stress in Centipedegrass.

SQUAMOSA promoter-binding protein-like (SPL) transcription factors play a critical role in the regulation of gene expression and are indispensable in orchestrating plant growth and development while also improving resistance to environmental stressors. Although it has been identified across a wide array of plant species, there have been no comprehensive studies on the gene family in centipedegrass [ (Munro) Hack.], which is an important warm-season perennial C4 turfgrass.

A novel salt-adapted bifunctional glucanase/mannanase from Klebsiella pneumoniae and its application in oligosaccharide production.

Klebsiella pneumoniae exhibits extensive glycohydrolase activity in the gut microbiota. However, there are few studies on glucomannanase of Klebsiella pneumoniae. This study cloned and characterized a bifunctional mannanase/glucanase (GH8-3995) of K.

Integration of machine learning and genome-wide association study to explore the genomic prediction accuracy of agronomic trait in oats (Avena sativa L.).

Machine learning (ML) has garnered significant attention for its potential to enhance the accuracy of genomic predictions (GPs) in various economic crops with the use of complete genomic information. Genome-wide association studies (GWAS) are widely used to pinpoint trait-related causal variant loci in genomes. However, the simultaneous integration of both methods for crop genome prediction necessitates further research.

Whole-exome sequencing association study reveals genetic effects on tumor microenvironment components in nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC) presents a substantial clinical challenge due to the limited understanding of its genetic underpinnings. Here we conduct the largest scale whole-exome sequencing association study of NPC to date, encompassing 6,969 NPC cases and 7,100 controls. We unveil 3 germline genetic variants linked to NPC susceptibility: a common rs2276868 in RPL14, a rare rs5361 in SELE, and a common rs1050462 in HLA-B.

Xuanhong Dingchuan Tang suppresses bronchial asthma inflammation via the microRNA-107-3p/PTGS2/MAPK axis.

This study aimed to investigate the mechanism of Xuanhong Dingchuan Tang (XHDCT) in delaying bronchial asthma inflammation via the microRNA (miR)-107-3p/prostaglandin endoperoxide synthase 2 (PTGS2)/mitogen-activated protein kinase (MAPK) axis. Based on the network pharmacological analysis, XHDCT chemical constituents and targets of each chemical constituent were screened through the TCMSP database, and differential-expressed genes of bronchial asthma were obtained from the GEO database, which were intersected to get XHDCT potential anti-inflammatory targets. The key anti-inflammatory targets of XHDCT were acquired by protein-protein interaction (PPI) analysis of the candidate targets.

Higher oxidative balance score is associated with lower female infertility: a cross-sectional study.

Background: An imbalance of the pro-oxidant and antioxidant profiles in the body contributes to the development of diseases, including female infertility.

Methods: In this study, we performed a secondary analysis of the National Health and Nutrition Examination Survey and calculated the values of oxidative balance score (OBS). A weighted logistic regression model was used to explore the potential relationship between OBS (continuous factor and quartile set) and female infertility, and the P for trend was calculated.

Observation of tunable accidental bound state in the continuum in silicon nanodisk array.

We experimentally demonstrate the tuning of accidental bound states in the continuum (A-BICs) in silicon nanodisk arrays. The A-BIC emerges of the destructive interference of multipoles, which are the dominating out-of-plane electric dipole and in-plane magnetic dipole, and weak electric quadrupole and magnetic quadrupole. We further show that the spectral and angular position of the A-BIC can be conveniently tuned by varying the nanodisk size or the lattice period.

Overproduction of Mitochondrial Fission Proteins and Mitochondrial Fission in Podocytes of Lupus Nephritis Patients.

Background: The glomerular injury is associated with different pathogeneses, and podocyte damage is common in various ISN/RPS class lupus nephritis (LN). In podocyte, mitochondrial morphological changes are observed in lupus nephritis (LN) in our previous study. This study aimed to explore mitochondrial fission proteins expression in podocytes using bioinformatics analysis and further to investigate the associations between mitochondrial fission proteins and laboratory features in LN.

Disruption of the odorant receptor co-receptor (Orco) reveals its critical role in multiple olfactory behaviors of a cosmopolitan pest.

The olfactory system of insects plays a pivotal role in multiple, essential activities including feeding, mating, egg laying, and host localization. The capacity of odorant receptors to recognize odor molecules relies on odorant receptor co-receptors forming heterodimers. Here we report the successful engineering a homozygous mutant strain of diamondback moth (Plutella xylostella) in which the odorant receptor co-receptor PxOrco was silenced using CRISPR/Cas9.

GNA14 may be a potential prognostic biomarker in nasopharyngeal carcinoma.

Background: Nasopharyngeal carcinoma (NPC) is a highly invasive malignant tumor. Recurrence and distant metastasis represent the primary causes of treatment failure. This study aimed to identify biomarkers highly associated with NPC and investigate its roles in tumor progression.

Lysophosphatidylcholine 14:0 Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Protecting Alveolar Epithelial Barrier by Activation of Nrf2/HO-1 Pathway.

Background: Acute lung injury (ALI) is characterized by diffuse alveolar injury and acute non-cardiac pulmonary edema, with high morbidity and mortality. Lysophosphatidylcholine 14:0 (LPC14:0) has anti-inflammatory and anti-oxidative effects in sepsis and bacteremia. We hypothesized that LPC14:0 could be a potential treatment for ALI.

16S rRNA Gene Sequencing Combined with Metabolomics to Explore Intestinal Flora and Metabolic Changes in Young Febrile Rats and the Mechanism of Xiangqin Jiere Granules.

Purpose: Xiangqin Jiere Granules (XQJRG), a Chinese patent medicine used to treat acute fever in children caused by colds, seasonal flu, and coronavirus disease 2019 has been proven to have antipyretic and anti-inflammatory effects in young febrile rats. Fever is known to affect the host-gut microbiota crosstalk. However, the pharmacological mechanism of XQJRG in this regard remains unclear.

Development and performance evaluation of a clinical prediction model for sepsis risk in burn patients.

Sepsis is a common and severe complication in burn patients and remains one of the leading causes of mortality. This retrospective study aimed to develop a predictive model for the risk of in-hospital sepsis among burn patients treated at Guangzhou Red Cross Hospital between January 2022 and January 2024, with the goal of improving clinical outcomes through early prevention based on risk stratification. A total of 302 eligible patients were randomly divided into training and validation cohorts in a 7:3 ratio for model development and validation, respectively.

Characterization of a novel cold-active β-Xylosidase from Parabacteroides distasonis and its synergistic hydrolysis of beechwood xylan.

Although β-xylosidases have broad applications in fields such as food and medicine, there is limited research on cold-active β-xylosidases. This study cloned a novel cold-active β-xylosidase XYL13 from Parabacteroides distasonis. The purified XYL13 exhibited the highest activity at 40 °C, with 42 % and 25 % of its maximum activity at 4 °C and 0 °C, respectively.