Histone Lactylation-Driven GPD2 Mediates M2 Macrophage Polarization to Promote Malignant Transformation of Cervical Cancer Progression.

Cervical cancer (CC) is the most common cancer in women. This study aims to explore the molecular mechanism of lactate secreted by CC cells modulating macrophage polarization in CC via histone lactylation. Normal cervical epithelium (NCE), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), and cervical squamous cell carcinoma (CESC) were collected to assess H3K18la level and macrophage infiltration.

The association between codon72 polymorphism of p53 gene and the risk of endometrial cancer: an updating meta-analysis.

Objective: Controversy still exists in the relationship between p53 codon72 polymorphism and the risk of endometrial cancer.

Materials And Methods: In order to figure out this inconsistency, database on HuGE Navigator, PubMed and Web of Science about the case-control studies were compiled in the present work. Statistic analysis was performed by STATA 12.

Susceptibility of human liver cells to porcine endogenous retrovirus.

Objectives: The risk of porcine endogenous retrovirus infection is a major barrier for pig-to-human xenotransplant. Porcine endogenous retrovirus, present in porcine cells, can infect many human and nonhuman primate cells in vitro, but there is no evidence available about in vitro infection of human liver cells. We investigated the susceptibility of different human liver cells to porcine endogenous retrovirus.