Atomistic Insights into the Ionic Response and Mechanism of Antifouling Zwitterionic Polymer Brushes.

Zwitterionic polymer brushes are not a practical choice since their ionic response mechanisms are unclear, despite their great potential for surface antifouling modification. Therefore, atomic force microscopy and molecular dynamics simulations investigated the ionic response of the surface electrical properties, hydration properties, and protein adhesion of three types of zwitterionic brushes. The surface of PMPC (poly(2-methacryloyloxyethyl phosphorylcholine)) and PSBMA (poly(sulfobetaine methacrylate)) zwitterionic polymer brushes in salt solution exhibits a significant accumulation of cations, which results in a positive shift in the surface potential.

Study of Hydration Repulsion of Zwitterionic Polymer Brushes Resistant to Protein Adhesion through Molecular Simulations.

The fabrication of antifouling zwitterionic polymer brushes represents a leading approach to mitigate nonspecific adhesion on the surfaces of medical devices. This investigation seeks to elucidate the correlation between the material composition and structural attributes of these polymer brushes in preventing protein adhesion. To achieve this goal, we modeled three different zwitterionic brushes, namely, carboxybetaine methacrylate (CBMA), sulfobetaine methacrylate (SBMA), and (2-(methacryloyloxy)ethyl)-phosphorylcholine (MPC).

High-density zwitterionic polymer brushes exhibit robust lubrication properties and high antithrombotic efficacy in blood-contacting medical devices.

High-performance catheters are essential for interventional surgeries, requiring reliable anti-adhesive and lubricated surfaces. This article develops a strategy for constructing high-density sulfobetaine zwitterionic polymer brushes on the surface of catheters, utilizing dopamine and sodium alginate as the primary intermediate layers, where dopamine provides mussel-protein-like adhesion to anchor the polymer brushes to the catheter surface. Hydroxyl-rich sodium alginate increases the number of grafting sites and improves the grafting mass by more than 4 times.

Design, preparation, and characterization of lubricating polymer brushes for biomedical applications.

The lubrication modification of biomedical devices significantly enhances the functionality of implanted interventional medical devices, thereby providing additional benefits for patients. Polymer brush coating provides a convenient and efficient method for surface modification while ensuring the preservation of the substrate's original properties. The current research has focused on a "trial and error" method to finding polymer brushes with superior lubricity qualities, which is time-consuming and expensive, as obtaining effective and long-lasting lubricity properties for polymer brushes is difficult.

Surface modification of polyvinyl chloride with sodium alginate/carboxymethyl chitosan and heparin for realizing the anticoagulation.

Thrombosis of extracorporeal circuits causes significant morbidity and mortality worldwide. In this study, plasma treatment technology and chemical grafting method were used to construct heparinized surfaces on the PVC substrate, which could not only reduce thrombosis but also decrease the side effects of the direct injection of anticoagulants. The PVC substrate was modified by plasma treatment technology firstly to obtain the active surface with the hydroxyl groups used for grafting.

Construction of the Mussel-Inspired PDAM/Lysine/Heparin Composite Coating Combining Multiple Anticoagulant Strategies.

The thrombosis of the extracorporeal circuits leads to serious complications, which affect the life safety of the patients significantly. However, intravenous anticoagulants such as heparin may induce bleeding, hypersensitivity, and other adverse reactions. In this study, the mussel-inspired composite coating consisting of polydopamine (PDAM), lysine, and modified heparin was constructed on the commonly used medical poly(vinyl chloride) (PVC) tubes to reduce thrombosis by combining the immobilization of anticoagulants and the construction of bioinert surface strategies.