Myristica fragrans water extract modulates multiple biological processes to pre-protect anhydrous ethanol-induced gastric ulcers via Akt/JNK/Nrf2 pathway activation.

Ethnopharmacological Relevance: Myristica fragrans (Nutmeg) is a commonly used Chinese herbal medicine and edible spice. According to Pharmacopoeia of People's Republic of China, it has the effects of warming the middle and promoting qi, astringent intestines, and antidiarrheal. In the record of Compendium of Materia Medica, it is the myristica fragrans water extract (MFWE) that is utilized for therapeutic purposes of gastrointestinal disorders frequently.

CircRNA-RBAC induces cardiac repair by promoting ribosome biogenesis and cell cycle progression in cardiomyocytes.

Ribosome biogenesis (RiBi) is an essential process that controls the protein synthesis rate, but its function in regulating endogenous cardiac regeneration remains unknown. Herein, we investigated the function and underlying mechanism of RiBi-associated circRNAs in cardiomyocyte (CM) proliferation and cardiac regeneration. We used high-throughput sequencing, quantitative PCR and in situ hybridization techniques to identify an adult downregulated circRNA, RiBi-associated circRNA (RBAC), in CMs.

Low-cost spatially variable polarizers via polarization holography.

In this study, we propose a novel, to the best of our knowledge, method for designing low-cost, continuously spatially variable polarizers using polarization holography. We use these devices to generate vector vortex beams and detect scalar vortex beams. Our approach begins with designing polarization holograms that act as polarizers, each with distinct transmission axes recorded at various polar angles on polarization-sensitive materials using a dynamic recording system.

Generation of polygonal non-diffracting beams via angular spectral phases.

In this study, an effective approach for generating polygonal non-diffracting beams (PNDBs) is demonstrated using optical caustics and cross-phases. The resulting structured light beams display a polygonal transverse structure and exhibit a significant intensity gradient and phase gradient. Diverse PNDBs can be generated by flexibly controlling the exponent factor of the cross-phases.

Neutrophil N1 polarization induced by cardiomyocyte-derived extracellular vesicle miR-9-5p aggravates myocardial ischemia/reperfusion injury.

Neutrophil polarization contributes to inflammation and its resolution, but the role of neutrophil polarization in myocardial ischemia/reperfusion (I/R) injury remains unknown. Cardiomyocytes (CMs) participate in cardiac inflammation by secreting extracellular vesicles (EVs). Therefore, we investigated the role of neutrophil polarization in myocardial I/R injury and the mechanism by which CM-derived EVs regulated neutrophil polarization.

Mathieu ray-wave structured light with self-healing elliptical accelerating vortices.

Ray-wave structured vortex beams have attracted increasing attention due to their unique spatial geometric coupling to control complex orbital angular momentum (OAM). Still, current models were constrained by circular symmetry with limited modulation freedom. Herein, we propose a generalized class of ray-wave light fields called Mathieu geometric modes (MGMs) fulfilling the form of a stationary coherent state but based on a set of helical Mathieu modes (HMMs), in which geometrically tunable elliptical accelerating vortices are obtained by tuning their eccentricity-related parameters.

Tert promotes cardiac regenerative repair after MI through alleviating ROS-induced DNA damage response in cardiomyocyte.

Telomerase reverse transcriptase (Tert) has been found to have a protective effect on telomeric DNA, but whether it could improve the repair of reactive oxygen species (ROS)-induced DNA damage and promote myocardial regenerative repair after myocardial infarction (MI) by protecting telomeric DNA is unclear. The immunofluorescence staining with TEL-CY3 and the TeloTAGGG Telomerase PCR ELISA kit were used to show the telomere length and telomerase activity. The heart-specific Tert-deletion homozygotes were generated by using commercial Cre tool mice and flox heterozygous mice for mating.

Where is the orbital angular momentum in vortex superposition states?

In this paper, we explore the distribution of the orbital angular momentum (OAM) in the coaxial vortex superposition states based on the independent propagation principle of light in this interference process. We find that in this case, some specific singular points exist in the spatial intensity distribution. The first type of singular point is located at the center point of the spatial intensity distribution.

Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching.

Introduction: Sympathetic hyperinnervation plays an important role in modulating the vascular smooth muscle cell (VSMC) phenotype and vascular diseases, but its role in abdominal aortic aneurysm (AAA) is still unknown.

Objectives: This study aimed to investigate the role of sympathetic hyperinnervation in promoting AAA development and the underlying mechanism involved.

Methods: Western blotting and immunochemical staining were used to detect sympathetic hyperinnervation.

Inhibiting the Aggregation of Aβ by Natural Product Molecules.

The abnormal aggregation of Aβ has been considered one of the primary causative factors for Alzheimer's disease. Diverse molecular entities have been developed to mitigate the formation of toxic Aβ aggregates within the brain by inhibiting Aβ aggregation. Recognizing that many FDA-approved drugs are derived from natural products, we present a summary of recent discoveries involving natural product molecules with inhibitory effects on Aβ aggregation.

Switchable hybrid-order optical vortex lattice.

Optical vortex (OV) modulation is a powerful technique for enhancing the intrinsic degrees-of-freedom in structured light applications. Particularly, the lattices involving multiple OVs have garnered significant academic interest owing to their wide applicability in optical tweezers and condensed matter physics. However, all OVs in a lattice possess the same order, which cannot be modulated individually, limiting its versatile application.

Optogenetic Stimulation of the Cardiac Vagus Nerve to Promote Heart Regenerative Repair after Myocardial Infarction.

It had been shown that selective cardiac vagal activation holds great potential for heart regeneration. Optogenetics has clinical translation potential as a novel means of modulating targeted neurons. This study aimed to investigate whether cardiac vagal activation via optogenetics could improve heart regenerative repair after myocardial infarction (MI) and to identify the underlying mechanism.

High-throughput sequencing-based analysis of the composition and diversity of the endophyte community in roots of Stellera chamaejasme.

Stellera chamaejasme (S. chamaejasme) is an important medicinal plant with heat-clearing, detoxifying, swelling and anti-inflammatory effects. At the same time, it is also one of the iconic plants of natural grassland degradation in northwest China, playing a key role in the invasion process.

Generation of arbitrarily structured optical vortex arrays based on the epicycle model.

Optical vortex arrays (OVAs) are complex light fields with versatile structures that have been widely studied in large-capacity optical communications, optical tweezers, and optical measurements. However, generating OVAs with arbitrary structures without explicit analytical expressions remains a challenge. To address this issue, we propose an alternative scheme for customizing OVAs with arbitrary structures using an epicycle model and vortex localization techniques.

Diversity analysis of sea anemone peptide toxins in different tissues of Heteractis crispa based on transcriptomics.

Peptide toxins found in sea anemones venom have diverse properties that make them important research subjects in the fields of pharmacology, neuroscience and biotechnology. This study used high-throughput sequencing technology to systematically analyze the venom components of the tentacles, column, and mesenterial filaments of sea anemone Heteractis crispa, revealing the diversity and complexity of sea anemone toxins in different tissues. A total of 1049 transcripts were identified and categorized into 60 families, of which 91.

Comparative Analysis of Chloroplast Genome of (Papaveraceae) Provides Insights into Their Genomic Evolution and Adaptation to High Elevation.

The species are widely distributed in the Qinghai-Tibet Plateau, Himalayas, and Hengduan Mountains in China, and have high medicinal and ornamental value. The high diversity of plant morphology in this genus poses significant challenges for species identification, given their propensity for highland dwelling, which makes it a question worth exploring how they cope with the harsh surroundings. In this study, we recently generated chloroplast (cp) genomes of two species, () and , and compared them with those of ten cp genomes to comprehend cp genomic features, their phylogenetic relationships, and what part they might play in plateau adaptation.

The complete chloroplast genome of Prain 1894 (Papaveraceae), a high-altitude plant distributed on the Qinghai-Tibet plateau.

Prain 1894 () is a rare herb within the family Papaveraceae of which unique and gorgeous purple flowers are blooming in the flowering phase. In this study, we reported the complete chloroplast (cp) genome of , which was mainly distributed on the Qinghai-Tibet plateau. The complete chloroplast genome sequence of was 153,073 bp in size and was characterized by a typical quadripartite structure consisting of a large single-copy (LSC) region of 83,562 bp, a small single-copy (SSC) region of 178,33 bp and two identical inverted repeats (IR) regions of 25,839 bp.

Tricuspid isthmus ablation with pulsed-field power by linear catheter: a case report.

Background: Pulsed-field ablation using annular or petal-shaped catheters had been proven to be effective for achieving electrical isolation of pulmonary veins in patients with atrial fibrillation. However, the utilization of linear pulse-field power for treating atrial flutter has yet to been documented.

Case Summary: In this report, we present a case involving the successful treatment of tricuspid isthmus-dependent atrial flutter treated with a linear pulsed-field catheter.

Polarization helicity and the optical spin-orbit Hall effect.

The optical spin-orbit Hall effect manifests the separation of the spin angular momentum (SAM) and the orbital angular momentum (OAM), yet it can be obtained for the radially polarized light and well controlled by the initial phase of the polarization state which leads to the twist of its distribution. In this paper, we introduce the polarization helicity to characterize the effect of the initial phase of the polarization states in the optical spin-orbit Hall effect. We find the polarization helicity of the radial polarization state can be modulated by changing its initial phase, and the polarization helicity of the high-order polarization state always is zero.

Cardiovascular disease and depression: a narrative review.

In clinical practice, it is frequently observed that cardiac and psychological disorders frequently co-occur, leading to the emergence of a field known as cardiovascular disease with depression. Depression, in particular, poses a remarkable risk for the evolution of cardiovascular disease and intimately relates to adverse cardiovascular outcomes and mortality. Moreover, individuals who are depressed exhibit a higher susceptibility to developing cardiovascular disease compared to those in good health.

Improved GNSS Ambiguity Fast Estimation Reduction Algorithm.

The fast and accurate solution of integer ambiguity is the key to achieve GNSS high-precision positioning. Based on the lattice theory of high-dimensional ambiguity solving, the reduction time consumption is much larger than the search time consumption, and it is especially important to improve the efficiency of the lattice basis reduction algorithm. The Householder QR decomposition with minimal column pivoting is utilized to pre-sort the basis vectors and reduce the number of basis vector exchanges during the reduction process by partial size reduction and relaxing the basis vector exchange condition to improve the reduction efficiency of the LLL algorithm.