Promising Proteolysis-Targeting Chimera for Mutant p53-R175H.

The tumor suppressor protein p53 is among the most commonly mutated proteins across a variety of cancer types. Notably, the p53 R175H mutation ranks as one of the most prevalent hotspot mutations. Proteolysis-targeting chimeras (PROTACs) represent a class of bifunctional molecules capable of harnessing the cellular ubiquitin-proteasome pathway to facilitate targeted protein degradation.

Antiparallel G-Quadruplex Formation Hinders Conversion to a Parallel Topology.

G-quadruplexes (G4s) are four-stranded structures formed by guanine-rich sequences. While their structures, properties, and applications have been extensively studied, an understanding of their folding processes remains limited. In this study, we investigated the folding of the sequence d[(GT)G] in potassium solutions, focusing on the impact of a folding intermediate on the overall folding process.