Publications by authors named "Xinzhao Wei"
Cancer Lett
November 2024
Article Synopsis
- Recent RET tyrosine kinase inhibitors (TKIs) show promise for treating RET-rearranged non-small cell lung cancer (NSCLC) and RET-mutated thyroid cancer, but resistance limits their effectiveness over time.*
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- A CRISPR/Cas9 screening identified genes related to drug-tolerant persister cells, revealing that loss of MED12 or MIG6 increases these resistant cells and activates EGFR, leading to treatment failure.*
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- Combining EGFR inhibitors with RET TKIs proved effective in overcoming resistance, and further experiments indicated that targeting either EGFR or RET enhances sensitivity to treatments in resistant cancer models.*
