Publications by authors named "Xinzhan Peng"
Article Synopsis
- The phthalocyanine photosensitizer Pc 4 targets mitochondria and endoplasmic reticulum membranes, causing photodamage to proteins like Bcl-2 and triggering apoptosis in cells when exposed to light.
- Researchers synthesized various analogs of Pc 4, with those featuring aminopropylsiloxy ligands showing better cell uptake and effectiveness, leading to stronger fluorescence and higher binding affinity to liposomes.
- Hydroxyl-bearing axial ligands in these analogs reduce aggregation, enhance lysosomal localization, and lead to significantly higher cell death rates compared to Pc 4, although they trigger apoptosis more slowly and through a different mechanism.
We report here a novel, water-soluble, nonfluorescent dye that efficiently quenches fluorescence from a broad range of visible and near-infrared (NIR) fluorophores in Förster resonance energy transfer (FRET) systems. A model FRET-based caspase-3 assay system was used to test the performance of the quencher dye. Fluorogenic caspase-3 substrates were prepared by conjugating the quencher, IRDye QC-1, to a GDEVDGAK peptide in combination with fluorescein (emission maximum approximately 540 nm), Cy3 (approximately 570 nm), Cy5 (approximately 670 nm), IRDye 680 (approximately 700 nm), IRDye 700DX (approximately 690 nm), or IRDye 800CW (approximately 790 nm).
View Article and Find Full Text PDFReported herein is a combination of experimental and DFT/TDDFT theoretical investigations of the ground and excited states of 1,4,8,11,15,18,22,25-Octabutoxyphthalocyaninato-nickel(II), NiPc(BuO)(8), and the dynamics of its deactivation after excitation into the S(1)(pi,pi) state in toluene solution. According to X-ray crystallographic analysis NiPc(BuO)(8) has a highly saddled structure in the solid state. However, DFT studies suggest that in solution the complex is likely to flap from one D(2)(d)-saddled conformation to the opposite one through a D(4)(h)-planar structure.
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