Genetic Variants in METTL16 Affect the Risk of Non-Syndromic Orofacial Clefts.

Objective: N6-methyladenosine (mA) is the most prevalent modification of RNA in eukaryotes which is associated with many cellular processes and diseases. Here, our objective is to explore whether genetic variants in mA modification genes are associated with the risk of non-syndrome orofacial clefts (NSOCs).

Methods: The transmission disequilibrium test (TDT) was performed to calculate the association between single nucleotide polymorphisms (SNPs) in mA modification genes and NSOCs risk in 944 case-parent trios.

Facial soft tissue characteristics of patients with different types of malocclusion.

Background: This study aimed to investigate the facial soft tissue characteristics of patients with different types of malocclusion.

Methods: The 3dMD scanning data of patients with malocclusion admitted to our hospital from January 2018 to April 2022 were analyzed retrospectively. Forty-seven patients with Class I malocclusion, 43 patients with Class II malocclusion and 44 patients with Class III malocclusion were selected.

Exploring Successful Cognitive Aging: Insights Regarding Brain Structure, Function, and Demographics.

In the realm of cognitive science, the phenomenon of "successful cognitive aging" stands as a hallmark of individuals who exhibit cognitive abilities surpassing those of their age-matched counterparts. However, it is paramount to underscore a significant gap in the current research, which is marked by a paucity of comprehensive inquiries that deploy substantial sample sizes to methodically investigate the cerebral biomarkers and contributory elements underpinning this cognitive success. It is within this context that our present study emerges, harnessing data derived from the UK Biobank.

lncRNA Regulates Proliferation and Migration by Targeting Matrix Gla Protein in Nonsyndromic Cleft Lip With or Without Cleft Palate.

Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common craniofacial birth defect with complex etiologies. Recently, the dysregulation of long noncoding RNAs (lncRNAs) has been implicated in many developmental diseases, including NSCL/P. However, the functions and mechanisms of lncRNAs in NSCL/P have not been fully elucidated.

Genetic variants in Mammalian STE20-like protein kinase 2 were associated with risk of NSCL/P.

Aim: Mammalian STE20-like protein kinase 2 (MST2) plays an important role in apoptosis and the development of many disorders. Here, we aim to explore if genetic variants in MST2 are associated with the risk of non-syndromic cleft lip with or without palate (NSCL/P).

Materials And Methods: The association study was performed in a two-stage study of 1,069 cases and 1,724 controls to evaluate the association between genetic variants in the MST2 and NSCL/P risk.

Effects of Patchwise Sampling Strategy to Three-Dimensional Convolutional Neural Network-Based Alzheimer's Disease Classification.

In recent years, the rapid development of artificial intelligence has promoted the widespread application of convolutional neural networks (CNNs) in neuroimaging analysis. Although three-dimensional (3D) CNNs can utilize the spatial information in 3D volumes, there are still some challenges related to high-dimensional features and potential overfitting issues. To overcome these problems, patch-based CNNs have been used, which are beneficial for model generalization.

A review of the application of three-dimensional convolutional neural networks for the diagnosis of Alzheimer's disease using neuroimaging.

Alzheimer's disease (AD) is a degenerative disorder that leads to progressive, irreversible cognitive decline. To obtain an accurate and timely diagnosis and detect AD at an early stage, numerous approaches based on convolutional neural networks (CNNs) using neuroimaging data have been proposed. Because 3D CNNs can extract more spatial discrimination information than 2D CNNs, they have emerged as a promising research direction in the diagnosis of AD.

Characterization of conidial autofluorescence in powdery mildew.

Autofluorescence is produced by endogenous fluorophores, such as NAD(P)H, lipofuscin, melanin, and riboflavin, indicating the accumulation of substances and the state of energy metabolism in organisms. As an obligate parasite, powdery mildew is wildly spread by air and parasitic crops. However, most identification studies have been based on morphology and molecular biology which were far too time- and labor-consuming, thus lacking characteristic, simple, and effective means.

Ectopic Expression of from Improves Resistance to Powdery Mildew Fungi ( UCSC1).

The (Resistance to Powdery Mildew 8) are atypical broad-spectrum resistance genes that provide resistance to the powdery mildew fungi. Powdery mildew of rubber tree is one of the serious fungal diseases that affect tree growth and latex production. However, the homologs in rubber tree and their role of resistance to powdery mildew remain unclear.

First Report of Stemphylium lycopersici Causing Leaf Spot on Hevea brasiliensis in China.

Hevea brasiliensis is widely planted in tropical and subtropical regions and is the main source of natural rubber production. The growth of rubber trees is plagued by various leaf diseases, resulting in decreased rubber production. From January to March in 2020, a severe leaf spots disease on Hevea brasiliensis found in Agricultural Science Base in Haidian campus of Hainan University (20° 03' 31″ N, 110° 19' 07″ E), Haikou, Hainan province, China.

WY195, a New Inducible Promoter From the Rubber Powdery Mildew Pathogen, Can Be Used as an Excellent Tool for Genetic Engineering.

Until now, there are few studies and reports on the use of endogenous promoters of obligate biotrophic fungi. The WY195 promoter in the genome of , the rubber powdery mildew pathogen, was predicted using PromoterScan and its promoter function was verified by the transient expression of the β- () gene. WY195 drove high levels of expression in dicotyledons and monocotyledons.