Resonance features integration of multiple terahertz metamaterials sensors for qualification and quantification of trace fluoroquinolone antibiotics.

Background: The residual fluoroquinolone antibiotics (FQs) in the environment and food has raised public concerns over their potential impact on human health. Terahertz metamaterial sensors (TMSs) have garnered significant attention due to their capability to enhance the interaction between terahertz waves and antibiotic molecules, enabling the detection of trace antibiotics. However, conventional quantitative and qualitative methods based on TMSs suffer from low accuracy and cumbersome processes, respectively.

Ginsenoside CK Promotes Cell Apoptosis via Regulating P53 Signal Pathway in Non-Small Cell Lung Cancer.

Non-small cell lung cancer (NSCLC) is a malignant tumor with high morbidity and mortality. Ginsenosides have been shown to have strong antitumor activity, inhibiting tumor cell growth and promoting apoptosis. In this paper, the effects of ginsenoside CK on the proliferation and apoptosis of NSCLC 95D and NCI-H460 cells were investigated by CCK8, colony formation assay, flow cytometry, fluorescence staining assay, and Western Blot, and it was found that ginsenoside CK could significantly inhibit the growth and proliferation of non-small cell lung cancer, and it was also clarified that the mechanism of its action was realized by the mitochondrial apoptosis pathway.

Efficacy assessment of glycyrrhetinic acid-modified liposomes loaded with doxorubicin hydrochloride and cucurbitine B for synergistic treatment of hepatocellular carcinoma.

Objective: Hepatocellular carcinoma (HCC) is characterized by a high incidence rate, aggressive invasion and metastasis, and a significant postoperative recurrence rate. Targeted therapy plays a crucial role in the precise treatment of HCC. Studies have demonstrated that Glycyrrhetinic acid (GA) specific receptors are overexpressed on the surface of HCC cells.

Examining the influence of two emotion regulation strategies on anxiety in Chinese college students: insights from cross-lagged and moderated network models.

Background: Anxiety, a prevalent and detrimental mental disorder, usually emerges in late adolescence and emerging adulthood. Emotion regulation strategies, namely expressive suppression and cognitive reappraisal, share a close relation with the onset and maintenance of anxiety. Yet the relation between anxiety and emotion regulation strategies remains controversial and warrants further clarification.

Travertine Mineralogical Characteristics and Spatial Distribution in Huanglong, China, a World Natural Heritage: Derived from Late Pleistocene to Early Holocene Glacial U-Shaped Valley Carbonate Deposits.

In the long and complex process of geological evolution, the rise of the Himalayan movement and the strong Quaternary glacial movement 400,000 years ago have shaped the highly distinctive travertine landform landscape of Huanglong, China. The overflow of karst water in the high travertine layer has formed magnificent waterfalls and wonderful karst caves as well as the world's largest open-air travertine beaches and pools. The unique travertine landscape has entered the public's vision.

Two thermochromic laminated veneer cellulose-based alizarin/stearic acid/nano‑silicon dioxide/hexagonal boron nitride composites encapsulated with xanthan gum and wood wax oil films, that have excellent temperature-responsive and thermal-storing capabilities.

Thermochromic wood-based phase change material (TWPCM) is a temperature-responsive, smart material that actively manages thermal energy in response to ambient temperature fluctuations. The material has become a central focus in research on thermal energy storage and temperature sensing in recent years. A key research direction is the incorporation of delignified veneer impregnated with thermochromic phase change material (TPCM) into a multi-layered structure to enhance the thermal energy storage capacity of TWPCM.

mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets.

Diabetic nephropathy is a prevalent complication of diabetes and stands as the primary contributor to end-stage renal disease. The global prevalence of diabetic nephropathy is on the rise, however, due to its intricate pathogenesis, there is currently an absence of efficacious treatments to enhance renal prognosis in affected patients. The mammalian target of rapamycin (mTOR), a serine/threonine protease, assumes a pivotal role in cellular division, survival, apoptosis delay, and angiogenesis.

Review of the Bioactivities and Mechanisms of Fungus Extracts and Compounds in Colon Cancer.

Colon cancer, a malignant tumor caused by a malignant lesion of the colonic mucosal epithelium, has seen a high incidence in recent years. Fungi contain polysaccharides, terpenes, flavonoids, and other chemical components, and the diversity of these components determines the strength of a fungus's biological activity. Studies have shown that the chemical components in fungi can be used as drugs to inhibit the growth of colon cancer.

Study on the lower limit of gas detection based on the snapshot infrared multispectral imaging system.

Snapshot multispectral imaging system is extensively utilized in the petrochemical industry for gas monitoring due to its intuitive imaging, traceability, and ability to monitor a wide range of gases. Determining the detection capability of the different bands of the multispectral camera for the gases to be monitored is a crucial prerequisite for the operationalization of the camera. The current evaluation methods of detection capability are mainly for single-spectrum cameras, which require constructing complex experimental environments and have poor applicability to different gases.

Integrated multi-omics with machine learning to uncover the intricacies of kidney disease.

The development of omics technologies has driven a profound expansion in the scale of biological data and the increased complexity in internal dimensions, prompting the utilization of machine learning (ML) as a powerful toolkit for extracting knowledge and understanding underlying biological patterns. Kidney disease represents one of the major growing global health threats with intricate pathogenic mechanisms and a lack of precise molecular pathology-based therapeutic modalities. Accordingly, there is a need for advanced high-throughput approaches to capture implicit molecular features and complement current experiments and statistics.

Modification and Synergistic Studies of a Novel Frog Antimicrobial Peptide against Biofilms.

The overuse of traditional antibiotics has resulted in bacterial resistance and seriously compromised the therapeutic efficacy of traditional antibiotics, making the exploration of new antimicrobials particularly important. Several studies have shown that bioactive peptides have become an important source of new antimicrobial drugs due to their broad-spectrum antibacterial action and lack of susceptibility to resistance. In this study, a novel bioactive peptide Nigrosin-6VL was characterised from the skin secretion of the golden cross band frog, , by using the 'shotgun' cloning strategy.

Glucocorticoid does not improve the renal prognosis of patients with diabetic nephropathy combined with acute tubulointerstitial nephritis: a retrospective analysis.

Background And Objectives: In clinical practice, some patients are diagnosed with diabetic nephropathy (DN) combined with acute tubulointerstitial nephritis (ATIN) through renal biopsy. There is relatively little research on the treatment and prognosis of such patients, and no consensus exists on the use of glucocorticoid for treatment. Therefore, our study explores the progression of DN combined with ATIN and the renal outcomes after treatment with glucocorticoid.

Ginsenoside Rd reduces cell proliferation of non-small cell lung cancer cells by p53-mitochondrial apoptotic pathway.

Ginsenoside Rd is a tetracyclic triterpenoid derivative, widely existing in , and other traditional Chinese medicines. Many studies have proved that ginsenoside Rd have a variety of significant biological activities on certain types of cancer. However, the mechanism of ginsenoside Rd remains unclear in lung cancer.

Unraveling the interplay of ferroptosis and immune dysregulation in diabetic kidney disease: a comprehensive molecular analysis.

Background: Diabetic kidney disease (DKD) is a primary microvascular complication of diabetes with limited therapeutic effects. Delving into the pathogenic mechanisms of DKD and identifying new therapeutic targets is crucial. Emerging studies reveal the implication of ferroptosis and immune dysregulation in the pathogenesis of DKD, however, the precise relationship between them remains not fully elucidated.

Ginsenoside Rb1 Inhibits the Proliferation of Lung Cancer Cells by Inducing the Mitochondrial-mediated Apoptosis Pathway.

Background: Lung cancer is one of the more common malignant tumors posing a great threat to human life, and it is very urgent to find safe and effective therapeutic drugs. The antitumor effect of ginsenosides has been reported to be a treatment with a strong effect and a high safety profile.

Objective: This paper aimed to investigate the inhibitory effect of ginsenoside Rb1 on 95D and NCI-H460 lung cancer cells and its pathway to promote apoptosis.

Metabolism of ADB-FUBIATA in zebrafish and pooled human liver microsomes investigated by liquid chromatography-high-resolution mass spectrometry.

Rationale: ADB-FUBIATA is one of the most recently identified new psychoactive substance (NPS) of synthetic cannabinoids. The co-use of in vitro (human liver microsomes) and in vivo (zebrafish) models offers abundant metabolites and may give a deep insight into the metabolism of NPS.

Methods: In vivo and in vitro metabolic studies of new synthetic cannabinoid ADB-FUBIATA were carried out using zebrafish and pooled human liver microsome models.

Review on active components and mechanism of natural product polysaccharides against gastric carcinoma.

One of the malignant tumors with a high occurrence rate worldwide is gastric carcinoma, which is an epithelial malignant tumor emerging from the stomach. Natural product polysaccharides are a kind of natural macromolecular polymers, which have the functions of regulating immunity, anti-oxidation, anti-fatigue, hypoglycemia, etc. Natural polysaccharides have remarkable effectiveness in preventing the onset, according to studies, and development of gastric cancer at both cellular and animal levels.

CRISPR/Cas9-based genome editing of 14 lipid metabolic genes reveals a sporopollenin metabolon ZmPKSB-ZmTKPR1-1/-2 required for pollen exine formation in maize.

Lipid biosynthesis and transport are essential for plant male reproduction. Compared with Arabidopsis and rice, relatively fewer maize lipid metabolic genic male-sterility (GMS) genes have been identified, and the sporopollenin metabolon in maize anther remains unknown. Here, we identified two maize GMS genes, ZmTKPR1-1 and ZmTKPR1-2, by CRISPR/Cas9 mutagenesis of 14 lipid metabolic genes with anther stage-specific expression patterns.

ApoE-modified liposomes encapsulating resveratrol and salidroside alleviate manifestations of Alzheimer's disease in APP/PS-1 mice.

Objective: Alzheimer's disease (AD) is a neurodegenerative disease that is associated with aging and is influenced by both genetic and environmental factors. Several studies and clinical trials have demonstrated that resveratrol (Res) and salidroside (Sal) are not only biologically safe but also influence AD biomarker trajectories. However, their clinical applications have been quite limited due to poor specificity, low solubility, and insufficient blood-brain barrier (BBB) penetration.

In vitro and in vivo metabolism of 3-Methoxyeticyclidine in human liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography-high-resolution mass spectrometry.

3-Methoxyeticyclidine (3-MeO-PCE), a phencyclidine-type substance, has a higher N-methyl-D-aspartate receptor binding affinity than phencyclidine and an involvement in fatal intoxication cases. The aim of this study was to identify new biomarkers and biotransformation pathways for 3-MeO-PCE. In vitro models were established using zebrafish and human liver microsomes for analysis of the phases I and II metabolites of 3-MeO-PCE by liquid chromatography-high-resolution mass spectrometry.

Hydrochemical characteristics and driving factors of travertine deposition in Huanglong, Sichuan, SW, China.

The hydrochemical characteristics were analyzed by mathematical statistics, the hydrochemical types were analyzed by Piper three line diagram, and the sources and influencing factors of main ions in surface water were discussed by Gibbs diagram and ion correlation analysis. The results show that the TDS of surface water in the study area is 109-559 mg·L, and the average value is 318.67 mg·L; The pH value is 6.

Triphasic regulation of ZmMs13 encoding an ABCG transporter is sequentially required for callose dissolution, pollen exine and anther cuticle formation in maize.

Introduction: ATP Binding Cassette G (ABCG) transporters are associated with plant male reproduction, while their regulatory mechanisms underlying anther and pollen development remain largely unknown.

Objectives: Identify and characterize a male-sterility gene ZmMs13 encoding an ABCG transporter in modulating anther and pollen development in maize.

Methods: Phenotypic, cytological observations, and histochemistry staining were performed to characterize the ms13-6060 mutant.

The ZmMYB84-ZmPKSB regulatory module controls male fertility through modulating anther cuticle-pollen exine trade-off in maize anthers.

Anther cuticle and pollen exine are two crucial lipid layers that ensure normal pollen development and pollen-stigma interaction for successful fertilization and seed production in plants. Their formation processes share certain common pathways of lipid biosynthesis and transport across four anther wall layers. However, molecular mechanism underlying a trade-off of lipid-metabolic products to promote the proper formation of the two lipid layers remains elusive.