Publications by authors named "Xinyun Shang"
Importance: Childhood adverse experiences have been linked with long-term risk of cardiovascular disease (CVD), yet the transgenerational associations between interparental behaviors and CVD remain poorly understood.
Objectives: To explore the association between exposure to childhood interparental physical violence and the subsequent risk of CVD and to examine whether the association is modified by adult depressive symptoms.
Design, Setting, And Participants: This population-based cohort study included data from the China Health and Retirement Longitudinal Study (CHARLS), an ongoing study recruiting individuals aged 45 years or older, dated between June 1, 2011, and December 31, 2020, with a follow-up duration of 9 years.
Article Synopsis
- - The study examined the relationship between remnant cholesterol and low-density lipoprotein cholesterol (LDL-C) and their impact on stroke risk in two large Chinese health cohorts (CHARLS and CHNS), focusing on individuals aged 45 and older.
- - Researchers found that participants with elevated remnant cholesterol had a higher risk of stroke, and those in the "discordantly high" remnant cholesterol group had significantly increased stroke risks compared to those with "discordantly low" remnant cholesterol levels.
- - The findings suggest that discrepancies between remnant cholesterol and LDL-C levels are linked to stroke risk among Chinese adults, even in those with normal LDL-C levels, highlighting the importance of remnant cholesterol in cardiovascular health.
Background: Triglyceride and glucose (TyG) index, a surrogate marker of insulin resistance, has been validated as a predictor of cardiovascular disease. However, effects of TyG-related indices combined with obesity markers on cardiovascular diseases remained unknown. We aimed to investigate the associations between TyG index and modified TyG indices with new-onset cardiovascular disease and the time-dependent predictive capacity using a national representative cohort.
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- The study investigated how the triglyceride-glucose (TyG) index and inflammation (measured by high-sensitivity C-reactive protein or hsCRP) together affect the risk of cardiovascular diseases in middle-aged and older Chinese adults using data from a national study (CHARLS).
- Involving 8,658 participants free of cardiovascular diseases at the start, the research found that those with high levels of both TyG and hsCRP had significantly higher risks of developing heart disease and stroke during the 7-year follow-up.
- The study also revealed that inflammation (hsCRP) contributed to 13.4% of the link between the TyG index and cardiovascular diseases,
Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study.
Front Endocrinol (Lausanne)
April 2024
Purpose: The debate over the causal and longitudinal association between cystatin C and stroke in older adults persists. Our aim was to assess the link between cystatin C levels, both measured and genetically predicted, and stroke risk.
Methods: This study employed a retrospective cohort design using samples of the China Health and Retirement Longitudinal Study (CHARLS), which is a nationally representative cohort recruiting individuals aged 45 years or above.