Publications by authors named "Xinyue Shao"

Glycolysis-related lactic acid overproduction creates an "ion-trapping" barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy. Therefore, normalization of tumor microenvironment via lactic acid neutralization can be a promising avenue for overcoming this therapeutic hurdle. In this study, the flexible liposomes loaded with sodium bicarbonate (NaHCO@Flip) were used as a nano-adjuvant to boost chemoimmunotherapy.

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cGAS/STING pathway, which is highly related to tumor hypoxia, is considered as a potential target for remodeling the immunosuppressive microenvironment of solid tumors. Metal ions, such as Mn, activate the cGAS/STING pathway, but their efficacy in cancer therapy is limited by insufficient effect on immunogenic tumor cell death of a single ion. Here, we evaluate the association between tumor hypoxia and cGAS/STING inhibition and report a polymetallic-immunotherapy strategy based on large mesoporous trimetal-based nanozyme (AuPdRh) coordinated with Mn (Mn@AuPdRh) to activate cGAS/STING signaling for robust adaptive antitumor immunity.

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Article Synopsis
  • The study examined ancient DNA from horse remains found in the Shihuyao tombs, dating back to the Han and Tang Dynasties in Xinjiang (approximately 2200 to 1100 years ago).
  • Researchers sequenced two high-quality mitochondrial genomes, identifying them within maternal haplogroups B and D, and noted a genetic link between Tang Dynasty horses and modern Akhal-Teke horses through the primitive haplotype G1.
  • The findings highlighted the importance of the ancient Silk Road in the spread of these horses and suggested that early domestication of the Akhal-Teke breed was primarily for military use.
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Background: Community-acquired pneumonia (CAP) is a global health concern due to its high rates of morbidity and mortality. Bacterial pathogens are common causes of CAP. It is one of the most common causes of acute respiratory distress syndrome (ARDS), a common severe respiratory system manifestation threatening human health.

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Attention-deficit/hyperactivity disorder (ADHD) lacks objective diagnostic markers. In clinical settings, reliance on subjective judgments can often lead to missed or misdiagnoses. Some biomarkers have been reported to be associated with ADHD, but using one biomarker alone is not enough.

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Ferroptosis has emerged as a promising therapeutic approach for glioma. However, its efficacy is often compromised by the activated GPX4-reduced glutathione (GSH) system and the poor brain delivery efficiency of ferroptosis inducers. Therefore, suppression of the GPX4-GSH axis to induce the accumulation of lipid peroxides becomes an essential strategy to augment ferroptosis.

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Activated platelets promote tumor progression and metastasis through active interactions with cancer cells, especially in promoting epithelial-mesenchymal transition (EMT) of tumor cells and shedding tumor cells into the blood. Blocking platelet-tumor cell interactions can be a potential strategy to inhibit tumor metastasis. Platelet activation requires energy produced from aerobic glycolysis.

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Platelet transfusion is essential in the treatment of platelet-related diseases and the prevention of bleeding in patients with surgical procedures. Platelet transfusion efficacy and shelf life are limited mainly by the development of platelet storage lesion (PSL). Mitigating PSL is the key to prolonging the platelet shelf life and reducing wastage.

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Article Synopsis
  • Cattle have been significant in Chinese history, but the introduction of Chinese taurine cattle remains unclear despite previous ancient DNA studies suggesting they are exotic.
  • Researchers analyzed mitochondrial genomes from 34 ancient taurine cattle samples dated from the late Neolithic to the Qin and Han dynasties, successfully sequencing 14 genomes.
  • The study found genetic exchange among domestic taurine cattle across regions, indicating cultural and trade interactions, and suggests that ancient northern Chinese taurine cattle contributed genetically to modern Tibetan cattle through the spread of agriculture and pottery culture.
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Cardiovascular and cerebrovascular diseases (CCVDs) are two major vasculature-related diseases that seriously affect public health worldwide, which can cause serious death and disability. Lack of targeting effect of the traditional CCVD treatment drugs may damage other tissues and organs, thus more specific methods are needed to solve this dilemma. Micro/nanomotors are new materials that can convert external energy into driving force for autonomous movement, which can not only enhance the penetration depth and retention rates, but also increase the contact areas with the lesion sites (such as thrombus and inflammation sites of blood vessels).

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Human cancers typically express a high level of tumor-promoting mutant p53 protein (Mutp53) with a minimal level of tumor-suppressing wild-type p53 protein (WTp53). In this regard, inducing Mutp53 degradation while activating WTp53 is a viable strategy for precise anti-tumor therapy. Herein, a new carrier-free nanoprodrug (.

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Article Synopsis
  • Fossils from horses, zebras, and asses show how different horse lineages evolved over time, with some dating back to North America and Ethiopia in the Pleistocene.
  • Researchers studied 26 ancient horse specimens from Northern China and sequenced their DNA, revealing that one lineage survived until about 3500 years ago, despite tough times for horses caused by climate change and human activities.
  • The study found that this horse lineage split from its ancestors between 2.3 to 2.7 million years ago, and its small genetic diversity made it harder for them to survive as a species.
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Pueraria lobata is a perennial legume, commonly used as a food source in China. The polysaccharides extracted from P. lobata have demonstrated various biological activities.

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Persulfate-based advanced oxidation technology exhibits great potential for hazardous organic pollutant removal from wastewater. Acceleration of pollutant degradation needs to be elucidated, particularly for heterogeneous catalytic systems. In this study, manganese oxide ordered mesoporous carbon composites (MnO@OMC) were prepared by nano-casting method and used for persulfate activation to degrade phenol.

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Ionic liquids (ILs) are gradually concerned due to their potential environmental and health risks. In this work, the chronic effects of imidazolium-based ILs, using [Cmim]Br as a representative, were evaluated using model animal Caenorhabditis elegans. Our results show that prolonged exposure (72 h) of ILs to the nematodes at concentrations of 5 and 10 mg/L induced adverse effects on the growth, locomotive behaviors and development.

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