The relationship between telomere length and aging-related diseases.

The intensifying global phenomenon of an aging population has spurred a heightened emphasis on studies on aging and disorders associated with aging. Cellular senescence and aging are known to be caused by telomere shortening. Telomere length (TL) has emerged as a biomarker under intense scrutiny, and its widespread use in investigations of diseases tied to advancing age.

Tremella-Like Ni-NiO with O-Vacancy Heterostructure Nanosheets Grown In Situ on MXenes for Highly Efficient Hydrogen and Oxygen Evolution.

Electronic modulation via heterostructures or vacancies has been recently regarded as an effective strategy to improve electrocatalytic activity by optimizing the adsorption free energies of hydrogen evolution reaction (HER) or oxygen evolution reaction (OER) active intermediates during the reaction. Herein, tremella-like Ni-NiO with O-vacancy heterostructure nanosheets grown in situ on TiCT MXenes (Ni-NiO/TiCT MXene) are fabricated via a facile strategy. Benefitting from the heterointerfaces between Ni and NiO, the synergetic coupling effects of MXenes and Ni-NiO heterostructures, the O-vacancies, and the unique architecture, the as-prepared Ni-NiO/TiCT MXene showed superior activity toward the HER and OER in alkaline electrolyte, only requiring overpotentials of 72 mV for the HER and 248 mV for the OER to offer 10 mA cm.

Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study.

Background: Proteinuria is one of the common manifestations of patients with preeclampsia (PE), but whether the severity of proteinuria is related to the pregnancy outcome of patients with preeclampsia remains controversial. The present study aimed to determine the relationship between 24-h proteinuria and adverse outcomes in patients with preeclampsia.

Methods: The present retrospective study included 329 pregnant women in Chongqing, China.

Fibrinogen-like protein 2 deficiency aggravates renal fibrosis by facilitating macrophage polarization.

Renal fibrosis has no effective target for its prevention or reversal. Fibinogen-like protein 2 (Fgl2) is a novel prothrombinase exhibiting coagulation activity and immunomodulatory effects. Although Fgl2 is known to play a vital role in the development of liver and interstitial fibrosis, its function in renal fibrosis remains unclear.