Unbalanced occlusal loading elicited remodeling responses in growing rat temporomandibular joints and Notch1/Hes1 signaling pathway expression.

Objective: We aimed to assess the impact of unbalanced occlusal loading on the TMJ and the expression of the Notch1/Hes1 signaling pathway using a unilateral occlusal loss rat model.

Methods: We established a unilateral occlusal defect animal model. At three different times, all female Wistar rats were randomized into three groups (4 weeks, 6 weeks, and 10 weeks): (1) unilateral occlusal loss experiment group (extraction of the left mandibular molars and trimming of the left mandibular incisors every other day), (2) restoring incisal occlusion experiment group (extraction of the left mandibular molars and trimming of the left mandibular incisors every other day for 4 weeks, and then the incisor trimming was stopped until 10 weeks), (3) control group (normal loading).

Clinicopathological characteristics, treatment patterns and outcomes in patients with HER2-positive breast cancer based on hormone receptor status: a retrospective study.

Background: Different hormone receptor (HR) expression patterns have significant biological and therapeutic implications in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, the distinction between HR-positive /HER2-positive (HR+/HER2+) and HR-negative/HER2-positive (HR-/HER2+) subtypes remains unclear.

Methods: This retrospective study analyzed 828 patients with HER2-positive breast cancer at the First Affiliated Hospital of Xi'an Jiaotong University from 2012 to 2022.