Publications by authors named "Xinyuan Kong"
J Affect Disord
June 2024
Article Synopsis
- The study aimed to create a predictive model for SSRI effectiveness in treating major depressive disorder (MDD) using cognitive neuropsychological theory and machine learning.
- Participants included 69 MDD patients and 36 healthy controls, assessed on clinical symptoms, negative biases, and EEG, before and after an 8-week SSRI treatment.
- Key findings indicated significant differences between MDD patients and controls in social support and cognitive biases, leading to the development of a machine-learning model with 83% accuracy in predicting treatment outcomes.
Psychol Med
September 2023
Article Synopsis
- The study investigates how individuals with obsessive-compulsive personality disorder (OCPD) respond to guilt in interpersonal situations compared to healthy controls (HCs).
- Researchers used two tasks to measure guilt-related behaviors, focusing on cooperation driven by anticipatory guilt and compensation after causing harm.
- Results reveal that those with OCPD display less guilt aversion and compensation behaviors, suggesting their reduced sensitivity to guilt may contribute to interpersonal difficulties.
J Affect Disord
July 2022
Article Synopsis
- The study aimed to explore decision-making patterns and cognitive characteristics in patients with major depressive disorder (MDD) across different clinical stages, using assessments and the balloon analogue risk task.
- Findings revealed that while remitted MDD patients showed improvements in certain psychological traits compared to first-episode patients, they still differed significantly from healthy controls, maintaining a conservative decision-making strategy.
- The study concluded that MDD patients exhibited stable risk-avoidance behaviors regardless of depressive state, with specific neural indicators (like FRN and P3 components) suggesting both state-dependent and state-independent impairments in decision-making processes.
J Affect Disord
December 2021
Article Synopsis
- Patients with major depressive disorder (MDD) show difficulties in decision-making, with neurophysiological mechanisms inadequately understood.
- A study involving MDD patients and healthy controls revealed that while the groups performed similarly on risk-taking tasks (BART), MDD patients displayed greater stability in risk aversion and larger brain responses to losses (FRN).
- The research suggests that heightened sensitivity to negative feedback may intensify depressive symptoms, with FRN potentially serving as a marker for this hypersensitivity in MDD.
