Publications by authors named "Xinyu Zeng"

PA1b-like peptides, which are extracted from the seeds of members of the Fabaceae family, display remarkable hypoglycemic and β-cell-protective activities when administered orally. However, the direct targets and mechanisms of action of these peptides in islet β-cells remain unclear. In this study, we found that PA1b-like peptides were mainly distributed in the cotyledon of soybean, rather than in the germ and seed coat.

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Hyperoxaluria can easily induce calcium oxalate (CaOx) crystals and cause cell damage, thereby increasing the risk of kidney stone formation. In this study, three sulfated polysaccharides (PSPs) were obtained by the sulfur trioxide-pyridine method. The antioxidant activity of PSPs and the inhibitory effects of PSPs on CaOx crystallization, cellular oxidative damage, and cellular inflammation were explored in vitro, and PSPs were used to treat hyperoxaluria-induced crystallization model mice in order to validate the stone-preventive effect of PSPs in vivo.

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Nasal endoscopy is crucial for the early detection of nasopharyngeal carcinoma (NPC), but its accuracy relies heavily on the clinician's expertise, posing challenges for primary healthcare providers. Here, we retrospectively analysed 39,340 nasal endoscopic white-light images from three high-incidence NPC centres, utilising eight advanced deep learning models to develop an Internet-enabled smartphone application, "Nose-Keeper", that can be used for early detection of NPC and five prevalent nasal diseases and assessment of healthy individuals. Our app demonstrated a remarkable overall accuracy of 92.

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Objectives: Pregnant women had a large demand for diagnosis and treatment, but the clinical research was not sufficient, and there were many barriers for pregnant women to participate in clinical research. This study aimed to systematically identify these barriers and facilitators, map them with Theoretical Domains Framework (TDF) and Behavior Change Techniques (BCTs) to inform the development of interventions promoting pregnant women's involvement in clinical research.

Methods: This was a mixed-methods systematic review.

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Article Synopsis
  • Drought significantly hinders seed germination, plant growth, and agricultural production, prompting a detailed examination of drought resilience in 196 rapeseed lines both under normal and drought stress conditions.
  • A genome-wide association study identified 37 significant SNP loci and 136 genes related to drought tolerance, highlighting the gene BnaA01g29390D as a promising target for enhancing drought resistance due to its increased expression in drought-resistant plants.
  • The research outlines critical components in drought response mechanisms, including transcription factors and proteins, and establishes a regulatory network indicating an ABA-dependent pathway that facilitates drought tolerance in rapeseed seedlings, providing a basis for future genetic improvement efforts.
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  • * Conducted in Jiangsu province, China, the research analyzed responses from 32,974 out of 40,000 distributed questionnaires among students aged 16-19 from 129 high schools.
  • * Results showed high levels of anxiety (58.18%) and study stress, revealing significant correlations: higher study stress linked to more anxiety and mobile phone addiction, while increased physical activity was associated with lower study stress and anxiety.
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The preparation of intelligent indicator films containing anthocyanins and their utilization for real-time monitoring of meat freshness represents a prominent research topic of food packaging. In this study, anthocyanins (ALR) were extracted from Lycium ruthenicum (LR) using solvent extraction. Subsequently, these anthocyanins were incorporated into films composed of soybean isolate protein (SPI), xanthan gum (XG) and agar, resulting in SPI/XG/Agar-ALR pH-responsive intelligent indicator films.

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  • The study investigates the importance of lymph node ratio (LNR) as a predictor of survival in patients with locally advanced gastric cancer (LAGC) who have undergone surgery after neoadjuvant immunochemotherapy (NICT).
  • It involves a retrospective analysis of 121 patients, where those with low LNR (≤33%) showed significantly better overall survival (88.5%) and progression-free survival (80.2%) compared to those with high LNR (>33%), with both groups showing p-values <0.001.
  • LNR was identified as an independent prognostic factor for both overall and progression-free survival, suggesting it could be a useful indicator for assessing outcomes in LAGC patients post-treatment.
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Background: Owing to the lack of evidence-based medical studies with large sample sizes, the surgical approach for the radical resection of rectal neuroendocrine tumors remains controversial.

Methods: We retrospectively collected the medical records of patients with rectal neuroendocrine tumors who underwent radical resection at 17 large tertiary care hospitals in China between January 1, 2010, and April 30, 2022. All patients were divided into laparoscopic and open surgery groups.

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Article Synopsis
  • * Researchers analyzed data from 1408 patients and identified key prognostic factors such as tumor grade, size, and nutritional index, forming the basis for the GATIS score.
  • * The GATIS score demonstrated better predictive accuracy for patient outcomes compared to traditional methods like TNM staging and WHO grading, indicating it could significantly enhance prognosis evaluation for R-NENs.
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Background/aim: Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer. The critical importance of circular RNA (circRNA) in a range of cancer types has been lately recognized. However, research on the functions of circRNAs in PTC has been limited thus far.

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Background: Acute myocardial infarction (AMI) is a severe acute coronary syndrome, demonstrating a trend toward affecting younger individuals in recent years. The association between early-onset myocardial infarction and single nucleotide polymorphism necessitates further exploration and evaluation.

Case Description: We present a case of a patient experiencing early-onset and recurrent myocardial infarction.

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To investigate the protective role of immune response gene 1 (IRG1) and exogenous itaconate in autoimmune hepatitis (AIH) and elucidate the underlying mechanisms. Wild-type and IRG1 AIH mouse models were established, and samples of liver tissue and ocular blood were collected from each group of mice to assess the effects of IRG1/itaconate on the expression of pro- and anti-inflammatory cytokines. The levels of liver enzymes and related inflammatory factors were determined using enzyme-linked immunosorbent assay and real-time quantitative polymerase chain reaction (PCR).

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  • Limited studies exist on the optimal treatment for rectal neuroendocrine tumors (R-NETs) measuring 1-2 cm, with this research exploring long-term outcomes and quality of life for affected patients.
  • The study analyzed data from 272 patients, comparing outcomes between those undergoing local excision (LE) and radical resection (RR), finding no significant differences in survival but better quality of life and fewer complications with LE.
  • The findings suggest that LE is preferable for patients without lymph node metastasis, while RR may be necessary for those with specific high-risk features like higher tumor location or elevated neutrophil-to-lymphocyte ratio.
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Article Synopsis
  • A study was conducted to compare the effectiveness of local excision versus radical resection for treating grade 2 rectal neuroendocrine tumors, as there is limited research on the subject.
  • A total of 144 patients from 17 medical centers in China were analyzed, revealing no significant differences in cancer survival for tumors ≤1.5 cm, but a notable difference in relapse-free survival for tumors >1.5 cm, favoring radical resection.
  • Limitations of the study include its retrospective nature and relatively short follow-up period, which may impact the reliability of the findings.
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Matrine, an alkaloid derived from the dried roots of Aiton, has been utilized for the treatment of liver diseases, but its potential hepatotoxicity raises concerns. However, the precise condition and mechanism of action of matrine on the liver remain inconclusive. Therefore, the objective of this systematic review and meta-analysis is to comprehensively evaluate both the hepatoprotective and hepatotoxic effects of matrine and provide therapeutic guidance based on the findings.

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The high incidence of adolescent depression has become the focus of social and academic attention. Exercise is an important method to improve adolescent depression, but its intervention effect is still controversial. This study first compares and analyzes the relevant studies at home and abroad and finds that exercise prescription in adolescent depression intervention is not accurate enough.

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Background: Renal interstitial fibrosis is the pathophysiological basis of type 2 diabetes mellitus (T2DM). Exercise appears to improve kidney interstitial fibrosis in T2DM, in which silent information regulator factor 2-related enzyme 1 (Sirt1) is a critical regulator. However, the role of Sirt1 in mediating exercise on renal tissue as well as its mechanism remains unknown.

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In 2009, a novel H1N1 influenza virus caused the first influenza pandemic of the 21st century. Studies have shown that the influenza M gene played important roles in the pathogenicity and transmissibility of the 2009 H1N1 pandemic ((H1N1)pdm09), whilst the underlying mechanism remains unclear. The influenza M gene encodes two proteins, matrix protein 1 and matrix protein 2, which play important roles in viral replication and assembly.

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Background: The prognostic nutritional index (PNI), alkaline phosphatase (ALP), and lymph node ratio (LNR) are reportedly related to prognosis. The aim of this study was to elucidate the clinical importance of the LNR and hematological parameters in patients with high grade rectal neuroendocrine neoplasms (HG-RNENs) who were undergoing radical resection.

Methods: We reviewed the medical records of patients with HG-RNENs from 17 large-scale medical centers in China (January 1, 2010-April 30, 2022).

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Ethnopharmacological Relevance: Gardenia jasminoides J.Ellis is widely used to treat liver diseases in traditional Chinese medicine. Geniposide, a major active constituent of Gardenia jasminoides J.

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In algae-bacteria symbiotic wastewater treatment, the excellent settling performance of algae-bacteria aggregates is critical for biomass separation and recovery. Here, the composition of extracellular polymeric substances (EPS), microbial profiles, and functional genes of algae-bacteria aggregates were investigated at different solid retention times (SRTs) (10, 20, and 40 d) during partial nitrification in photo sequencing bioreactors (PSBRs). Results showed that SRTs greatly influenced the nitrogen transformation and the formation and morphological structure of algae-bacteria aggregates.

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The mechanism behind the onset of depression has been the focus of current research in the neuroscience field. Silent information regulator 1 (SIRT1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g.

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Background: The drug selection of radical surgery (RS), with hyperthermic intraperitoneal chemotherapy (HIPEC), in pT4 colorectal cancer (CRC) remains controversial.

Methods: Adverse events after HIPEC were estimated by common terminology criteria for adverse events version 5.0.

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Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) in T4 colorectal cancer (CRC) remains controversial. The study aimed to explore the safety and efficacy of radical surgery (RS) with HIPEC in T4 CRC.

Methods: Adverse events after HIPEC were estimated by Common Terminology Criteria for Adverse Events version 5.

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