Genetic evidence of the causal relationships between psychiatric disorders and cardiovascular diseases.

Objective: Our primary objective is to investigate the causal relationships between 12 psychiatric disorders (PDs) and atrial fibrillation (AF), coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF).

Methods: Firstly, we used linkage disequilibrium score regression to calculate the genetic correlations between 12 PDs and 4 cardiovascular diseases (CVDs). Subsequently, we performed two-sample and bidirectional Mendelian randomization (MR) analyses of phenotypes with significant genetic correlations to explore the causal relationships between PDs and CVDs.

Biologically generated turbulent energy flux in shear flow depends on tensor geometry.

It has been proposed that biologically generated turbulence plays an important role in material transport and ocean mixing. Both experimental and numerical studies have reported evidence of the nonnegligible mixing by moderate Reynolds number swimmers, such as zooplankton, in quiescent water, especially at aggregation scales. However, the interaction between biologically generated agitation and the background flow, as a key factor in biologically generated turbulence that could reshape our previous knowledge of biologically generated turbulence, has long been ignored.

WRKY41/WRKY46-miR396b-5p-TPR module mediates abscisic acid-induced cold tolerance of grafted cucumber seedlings.

Grafting is one of the key agronomic measures to enhance the tolerance to environmental stresses in horticultural plants, but the specific molecular regulation mechanism in this tolerance largely remains unclear. Here, we found that cucumber grafted onto figleaf gourd rootstock increased cold tolerance through abscisic acid (ABA) activating WRKY41/WRKY46-miR396b-5p-TPR (tetratricopeptide repeat-like superfamily protein) module. Cucumber seedlings grafted onto figleaf gourd increased cold tolerance and induced the expression of miR396b-5p.

A novel social distance model reveals the sidewall effect at bottlenecks.

Intermittent and periodic outbreaks of infectious diseases have had profound and lasting effects on societies throughout human history. During the global spread of SARS-CoV-2 and the resulting coronavirus disease (COVID-19), social distance has been imposed worldwide to limit the spread of the virus. An additional deliberate intention of keeping a minimum safety distance from neighbors can fundamentally alter the "social force" between individuals.

Bell Diagonal and Werner State Generation: Entanglement, Non-Locality, Steering and Discord on the IBM Quantum Computer.

We propose the first correct special-purpose quantum circuits for preparation of Bell diagonal states (BDS), and implement them on the IBM Quantum computer, characterizing and testing complex aspects of their quantum correlations in the full parameter space. Among the circuits proposed, one involves only two quantum bits but requires adapted quantum tomography routines handling classical bits in parallel. The entire class of Bell diagonal states is generated, and several characteristic indicators, namely entanglement of formation and concurrence, CHSH non-locality, steering and discord, are experimentally evaluated over the full parameter space and compared with theory.

Gibberellin mediates spermidine-induced salt tolerance and the expression of GT-3b in cucumber.

Numerous studies have demonstrated that spermidine (Spd) plays a critical role in salt tolerance in plants, but the associated mechanism remains largely unknown. In this study, we investigated the role of gibberellin (GA) in Spd-induced salt tolerance and the expression of GT-3b transcription factor in cucumber. The results showed that exogenous Spd significantly increased the salt tolerance of cucumber plants, while its effects were compromised in the presence of methylglyoxal bis-guanylhydrazone (MGBG), an inhibitor of Spd biosynthesis.