Surface-enhanced Raman spectroscopy (SERS) has become a revolutionary technique in the biomedical field, providing unparalleled sensitivity for the detection and characterization of biological samples. In this review, recent SERS innovations are comprehensively discussed, including advanced substrate materials, different SERS detection strategies, and multimodal approaches that combine SERS with other biotechnologies. Among them, the role of SERS in the accurate diagnosis of tumors is highlighted, which has promoted accurate molecular analysis and real-time monitoring of treatment effects.
View Article and Find Full Text PDFBiosens Bioelectron
January 2025
Detecting circulating tumor cells (CTCs) from blood has become a promising approach for cancer diagnosis. Surface-enhanced Raman Spectroscopy (SERS) has rapidly developed as a significant detection technology for CTCs, offering high sensitivity and selectivity. Encoded SERS bioprobes have gained attention due to their excellent specificity and ability to identify tumor cells using Raman signals.
View Article and Find Full Text PDFAutologous nerve transplantation (ANT) remains the gold standard for treating nerve defects. However, its efficacy in nerve repair still requires improvement. Mitochondrial dysfunction resulting from nerve injury may be a significant factor limiting nerve function restoration.
View Article and Find Full Text PDFPeptidyl arginine deiminase 4 (PAD4)-mediated neutrophil extracellular traps (NETs) play a crucial role in the pathogenesis of ulcerative colitis (UC). The cGAS-STING intracellular DNA-sensing pathway has been recognized as a pivotal mediator of inflammation. This study aimed to explore how NETs contribute to intestinal inflammation and barrier dysfunction in UC, focusing on the cGAS-STING pathway.
View Article and Find Full Text PDFFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the TUNEL assay data shown in Fig. 1C on p. 2853 and Fig.
View Article and Find Full Text PDFBackground And Objectives: Malnutrition is associated with a higher risk of osteoporosis. We aim to assess the relationship between serum albumin with geriatric nutritional risk index and osteopenia in Chinese elderly men.
Methods And Study Design: This is a nested case-control study from a prospective cohort enrolled 1109 individuals who were followed for seven years.
The efficiency of photocatalytic hydrogen evolution can be significantly enhanced while maintaining cost-effectiveness through the synergistic effect of defect surface engineering and multi-component heterojunctions. The structure and properties of NiCoO nanorods were modified by inducing oxygen vacancies at different temperatures in this study, resulting in improved optical properties and electron adsorption capacity. The presence of oxygen vacancies leads to a reduction in the band gap of NiCoO, thereby enhancing electron transport efficiency through band gap engineering.
View Article and Find Full Text PDFInactivated vaccines play an important role in preventing and controlling the epidemic caused by the H5 subtype avian influenza virus. The vaccine strains are updated in response to alterations in surface protein antigens, while an avian-derived vaccine internal backbone with a high replicative capacity in chicken embryonated eggs and MDCK cells is essential for vaccine development. In this study, we constructed recombinant viruses using the clade 2.
View Article and Find Full Text PDFUlcerative colitis (UC) is an inflammatory bowel disease (IBD) that is currently difficult to treat effectively. Both (BN) and ginseng-soluble dietary fiber (GSDF) are anti-inflammatory and helps sustain the intestinal barrier. In this study, the protective effects and mechanism of the combination of JLCC513 and ginseng-soluble dietary fiber (BG) in DSS-induced UC mice were investigated.
View Article and Find Full Text PDFIn this study, we conducted an analysis of the differences in nutrient composition and protein structure among various fermented soybean products and their impacts on the gut microbiota of rats. Conventional physicochemical analysis was employed to analyze the fundamental physicochemical composition of the samples. Additionally, we utilized high-performance liquid chromatography and ELISA techniques to quantify the presence of antinutritional compounds.
View Article and Find Full Text PDF() is one of the four main, woody, edible oil tree species in the world, while anthracnose is mainly caused by the fungus (), which severely affects the yield of and the quality of tea oil. () CSUFT-BV4 is an antagonistic endophytic bacterium isolated from healthy leaves. This study aimed to investigate the biocontrol potential of strain CSUFT-BV4 against anthracnose and its possible functional mechanism, and to determine its growth-promoting characteristics in host plants.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
February 2024
Background: Astragalus polysaccharides (APS) have been verified to have antioxidative and antiaging activities in the mouse liver and brain. However, the effect of APS on aortic endothelial senescence in old rats and its underlying mechanism are currently unclear. Here, we aimed to elucidate the effects of APS on rat aortic endothelial oxidative stress and senescence in vitro and in vivo and investigate the potential molecular targets.
View Article and Find Full Text PDFOutbreaks of viral infectious diseases, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV), pose a great threat to human health. Viral spread is accelerated worldwide by the development of cold chain logistics; Therefore, an effective antiviral approach is required. In this study, it is aimed to develop a distinct antiviral strategy using nanozymes with low-temperature adaptability, suitable for cold chain logistics.
View Article and Find Full Text PDFSoybean meal (SBM) is a high-quality vegetable protein, whose application is greatly limited due to its high molecular weight and anti-nutritional properties. The aim of this study was to modify the protein of soybean meal via solid-state fermentation of . The fermentation conditions were optimized as, finally, the best process parameters were obtained, namely fermentation temperature of 37 °C, inoculum amount of 12%, time of 47 h, and material-liquid ratio of 1:0.
View Article and Find Full Text PDFThe precursors that appear when geological disasters occur are geotechnical deformations. This paper studies the TDR (Time Domain Reflection) measurement technology for the distributed measurement of geotechnical deformation using parallel spiral wire as a sensor, which is used for monitoring and early warning detection of geological disasters. Based on the mechanism of the electromagnetic field distribution parameters of the parallel spiral sensing wire, the relationship between the stretching amount of the parallel spiral wire and the change in its characteristic impedance is analyzed.
View Article and Find Full Text PDFInfluenza virus with numerous subtypes and frequent variation limits the development of high-efficacy and broad-spectrum antiviral strategy. Here, a novel multi-antiviral metastable iron sulfides (mFeS) against various influenza A/B subtype viruses is developed. This work finds that mFeS induces high levels of lipid peroxidation and •OH free radicals in the conservative viral envelope, which depends on Fe .
View Article and Find Full Text PDFPurpose: Older patients with non-thyroidal illness syndrome (NTIS) have a poor prognosis. However, there are few studies on the association of NTIS and mortality among older inpatients on general wards. In a 7-year retrospective observational study, we aimed to investigate the clinical features of NTIS and the association of NTIS and all-cause mortality in older inpatients.
View Article and Find Full Text PDFSoybean residue is a by-product of soybean product production that is wasted unreasonably at present. Accomplishing the efficient utilization of soybean residue can save resources. A composite microbial system was constructed using lactic acid bacteria (LAB) and (SC), and modified soybean residue was prepared by solid fermentation.
View Article and Find Full Text PDFThis longitudinal cohort study explored the associations of 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), and β-C-terminal telopeptide of type 1 collagen (β-CTX) levels with all-cause mortality in centenarians. The study included 952 centenarians (81.4% female).
View Article and Find Full Text PDFNeuro Endocrinol Lett
November 2022
Objective: Parathyroid carcinoma (PC) is a rare disease with high rates of misdiagnosis and recurrence. This report summarized the clinical and pathological characteristics of 10 patients with PC at our hospital, to improve the early recognition and prognosis of PC.
Methods: The clinical manifestations, imaging findings, pathological features, treatments, and prognostic data of 10 patients diagnosed with PC at the First Medical Center, Chinese PLA General Hospital from 2003 to 2021 were analyzed.