Publications by authors named "Xinyu Hu"

Background: The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) is a novel marker related to atherosclerosis, but its role in diabetic kidney disease (DKD) remains unclear. This study investigated the relationship between NHHR and DKD risk in patients with type 2 diabetes mellitus (T2DM) and evaluated its potential as a marker for early DKD screening.

Methods: Data from adults with T2DM participating in the National Health and Nutrition Examination Surveys (NHANES) from 1999 to 2018 were analyzed.

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The trend of global population aging is becoming increasingly evident, with the proportion of the elderly population continuously rising, making it one of the most profound demographic trends of the 21st century. As people age, their sensory functions generally decline, such as vision, hearing, smell, and taste, which not only affects their food choices and enjoyment but can also lead to health issues like malnutrition and weight loss. In addition, chronic diseases such as diabetes, cardiovascular diseases, and the COVID-19 pandemic can exacerbate sensory impairments in older adults.

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NaFe(PO)(PO) (NFPP) is a promising cathode material for sodium-ion batteries with cost-effectiveness and structural stability. However, its electrochemical behaviors are seriously hindered by its [PO] distortion at high voltage. To address this challenge, we introduce a distortion criterion and optimize the local crystal field environment by incorporating Cr into Fe3 sites adjacent to [PO].

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We present a DNA sensor array for simultaneous detection of four targeted miRNAs in serum for early-stage lung cancer screening. Owing to effective microfluidic enrichment coupled with ultrasensitive solid-liquid capacitive sensing, the detection limit is as low as 12.84-24.

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Background: Journal clubs have proved to be very important in postgraduate education. This method is based on a problem-oriented teaching methodology. However, it is less commonly used in teaching undergraduate medical students.

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Pregnancy disorders in patients with autoimmune diseases or viral infections are often associated with an excessive response of type I interferons. We identify radical S-adenosyl methionine domain containing 2 (RSAD2) as a pathogenic interferon-stimulated gene (ISG) associated with pregnancy complications in systemic lupus erythematosus (SLE). The increased expression of RSAD2 mainly occurs in macrophages and structural cell populations at the maternal-fetal interface of pregnant patients with SLE.

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Low economic returns limit the widespread cultivation of bamboo, which could otherwise offer solutions to several global needs. This study aims to explore the physicochemical properties of nanoparticles (NPs) in protein solutions extracted from Moso bamboo shoots to enhance bamboo shoot applications. A 10 kDa molecular weight cutoff filter is used for protein purification, while amino acid composition analysis, SDS-PAGE, three independent spectroscopic techniques, and light scattering are employed for characterization.

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O3-type cathodes hold considerable promise in achieving rapid commercialization due to high energy density. However, severe structural/interfacial deterioration, along with kinetic hindrance, typically resulting in rapid capacity fading and serious safety risk at elevated cut-off voltages. Herein, inspired from solubility limitation of hetero-elements, synchronous surface-to-bulk multifunctionally full-scale modified O3-NaNiFeMnO is proposed to maintain its state of health (SOH).

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The diabetic foot ulcer is among the most serious diabetes-associated complications, with a long disease course considerably increasing the pain and economic burden of patients, leading to amputation and even death. High blood sugar is characteristic of diabetic foot ulcers, with insufficient blood supply, oxidative stress disorder, and high-risk bacterial infection posing great challenges for disease treatment. Advances in hydrogel dressings have shown potential for the management of diabetic foot ulcers involving multisystem lesions.

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Nocturia is an increasingly prevalent chronic disease that affects the quality of an individual's life. The prevalence of nocturia exceeds 50% among older adults in the U.S.

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Anji Baicha (Camellia sinensis), one of the top 10 teas in China, possesses old leaves rich in bioactive ingredients yet is frequently discarded due to inferior taste. This study evaluated the effects of fermentation with Eurotium cristatum, a probiotic known to enhance bioactivity, on the primary nutrients and on the hypoglycemic and sedative properties of old leaves of Anji Baicha. Results indicated a considerable reduction in free amino acids and tea polyphenols post-fermentation.

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Objective: The purpose of this study was to assess the severity of hemifacial spasm (HFS) through quantitative measures that associated it with neurovascular contact (NVC).

Methods: We enrolled 108 HFS patients (63 severe and 45 mild cases) and implemented a human-in-the-loop approach to develop a quantitative NVC feature package. This process involved using interactive segmentation on three-dimensional volumetric interpolated breath-hold examination (VIBE) MR images to delineate vascular and nerve structures.

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The advancement in heat treatment technology has spurred the innovation of various smart cooking appliances, including the steam roaster. Consequently, the technique of synchronized steaming and baking has emerged as a novel form of thermal processing. Therefore, the effects of baking, steaming, steaming-baking heating modes on the flavor of Hu sheep mutton were evaluated.

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Background: Post-traumatic stress disorder (PTSD) is a complex psychiatric condition that emerges following exposure to trauma and significantly affects daily functioning. Current research is focused on identifying effective treatments for PTSD. Advances in bioinformatics provide opportunities to elucidate the underlying mechanisms of PTSD.

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RNase III, a ubiquitously distributed endonuclease, plays an important role in RNA processing and functions as a global regulator of gene expression. In this study, we explored the role of RNase III in mediating the oxidative stress response in Synechocystis sp. PCC 6803.

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Objectives: The prevalence of Alzheimer's disease (AD) is increasing globally, however its pathogenesis is still unclear. The evidence showed that the progression of AD was closely related to the apoptosis of nerve cells. This study amis to explore the role and specific mechanism of miR-15a and Bag5 in the apoptosis of nerve cells induced by beta-amyloid protein (Aβ) in AD.

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Article Synopsis
  • Accurate meteorological observation data is crucial for human activities, but challenges like sensor malfunctions can lead to data inaccuracies.
  • A new deep learning method using autoencoders, SHAP, and Bayesian optimization is proposed for detecting these data anomalies quickly and accurately.
  • This method involves analyzing reconstruction errors in data, assessing the importance of different meteorological elements, setting appropriate anomaly thresholds, and fine-tuning model parameters to enhance detection accuracy, benefiting areas like agriculture and disaster prevention.
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The Platelet-to-Lymphocyte Ratio (PLR) has emerged as a cost-effective biomarker for systemic inflammation and adverse cardiovascular outcomes, yet its prognostic value in critically ill patients with heart failure (HF) remains unclear. Leveraging the MIMIC-IV database, this study investigates the association between PLR and 1-year all-cause mortality in 7,217 ICU patients with HF. Patients were stratified into tertiles (0-126.

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The defoliation quality of mugwort defoliation equipment is an important factor to measure the defoliation efficiency, and the tensile properties of mugwort petiole will have an impact on the defoliation quality, such as the crushing rate and the abscission rate. In order to reduce the crushing rate and improve the abscission rate during mechanical harvesting of mugwort leaves, the tensile properties of mugwort petiole need to be studied. The tensile properties of mugwort petiole are closely related to its macroscopic and microscopic physicochemical parameters.

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In this paper, the interaction between egg white protein (EWP) and giant squid surimi was regulated by changing the ratio of surimi to EWP, and the mechanism of EWP on the gel properties of giant squid surimi was analyzed. The results showed that when the proportion of EWP was 16: 1, the hardness and springiness of surimi gel were the highest, reaching 645.5 g and 1.

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Article Synopsis
  • Two soybean protein isolates (SPI) with differing molecular weights (high - GN, low - DN) were compared, revealing distinct nanoparticle (NP) characteristics in their solutions.
  • GN NPs were larger, more compact, and stable with more negative charges than DN NPs, and both underwent shape changes when diluted.
  • The study highlights how differences in NP properties between the two SPIs can affect their behavior during food processing, providing valuable information for raw materials selection in the food industry.
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Cryptosporidium species can infect humans and more than 260 animal species, including 54 rodent species. However, data on the occurrence and genetic characterizations of Cryptosporidium spp. in laboratory rodents are limited.

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Background: Predicting the survival time of patients at the end of life can provide more accurate treatment and care programs for patients. The purpose of this study was to investigate the factors impacting 14-day survival at the end of life.

Method: This was a retrospective study.

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Fusarium oxysporum is a destructive plant pathogen with robust survival mechanisms, complicating control efforts. This study aimed to develop nanoformulated fungicides, screen antagonistic bacteria, and evaluate their combined efficacy. A novel self-emulsifying nanoemulsion (DZW) was formulated using zein and benzaldehyde-modified wheat gluten (BgWG) as carriers for dimethachlon (DTN).

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Background: With the acceleration of population aging, depressive symptoms in older adults have become an urgent global public health issue. It is critical to understand how to prevent and intervene the epidemic of depressive symptoms. Several studies have reported the prevalence of depressive symptoms among older adults in urban and rural China, but there is a lack of cross-sectional studies on the prevalence of depressive symptoms among older adults in Anhui Province after the COVID-19 pandemic.

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