N-acetylneuraminic acid (NANA) can be used as a biomarker for many types of cancers. Currently, there are various methods for detecting NANA but showing some shortcomings that limit the real-time diagnosis of cancer. In contrast, fluorescence analysis has obvious advantages such as low cost, fast response time, and easy operation, and it also enables visual detection for real-time cancer monitoring.
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January 2025
A novel ratiometric fluorescence nanoprobe was developed to detect tryptophan enantiomers with high selectivity and sensitivity. Fluorescein (FL) was doped into SiO nanoparticles with little dye leakage, acting as an internal reference signal. The chiral center of L-histidine (L-His) was introduced by partially replacing the carboxyl on the surface of SiO.
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