Publications by authors named "Xinyou Xie"

Whole genome sequencing (WGS) potentially represents a rapid approach for antimicrobial resistance genotype-to-phenotype prediction. However, the challenge still exists to predict fully minimum inhibitory concentrations (MICs) and antimicrobial susceptibility phenotypes based on WGS data. This study aimed to establish an artificial intelligence-based computational approach in predicting antimicrobial susceptibilities of multidrug-resistant from WGS and gene expression data.

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  • - Emerging research indicates that the APOBEC family plays a significant role in various cancers, including clear cell renal cell cancer (ccRCC), suggesting it could be a target for cancer detection and treatment.
  • - The study categorized ccRCC patients into two subtypes, APOBEC pattern cancer subtype 1 (APCS1) and subtype 2 (APCS2), revealing distinct differences in clinical features, tumor immune environment, and treatment responses between them.
  • - The aggressive APCS1 subtype is associated with poorer prognosis due to higher tumor mutation loads and immune dysfunction, while a predictive risk model based on APOBEC-related biomarkers shows promise for improving prognosis assessments in ccRCC patients.
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Breast cancer (BC) is currently the most prevalent malignancy worldwide, and finding effective non-invasive biomarkers for routine clinical detection of BC remains a significant challenge. Here, we performed non-targeted and targeted metabolomics analysis on the screening, training and validation cohorts of serum samples from 1,947 participants. A metabolite biomarker model including glutamate, erythronate, docosahexaenoate, propionylcarnitine, and patient's age was established for detecting BC.

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  • Human species are increasingly recognized as opportunistic pathogens that contribute to various health issues, including genitourinary tract infections, infertility, and neonatal morbidities.
  • The review aims to fill gaps in understanding the molecular epidemiology, antimicrobial resistance, and pathogenic processes related to these infections.
  • It covers conventional and molecular detection methods, global antibiotic resistance trends, the development of novel antibiotics, and discusses the pathogenic mechanisms of these pathogens, such as adhesion and immune evasion.
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  • Cell cycle dysregulation is crucial in breast cancer, and 1-methyl-nicotinamide (1-MNA), a product of the enzyme NNMT, is identified as a key factor driving cell-cycle progression in this disease.* -
  • High NNMT levels in breast cancer tissues correlate with more aggressive tumors, and reducing NNMT significantly inhibits cell growth and causes a halt in the early stages of the cell cycle.* -
  • 1-MNA promotes the breakdown of the p27 protein, which regulates the cell cycle, by enhancing a process called neddylation, ultimately facilitating cancer progression and potentially altering the tumor's environment.*
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Mycoplasma hominis, a commensal bacterium that commonly inhabits the genital tract, leading to infections in both the genitourinary and extragenital regions. However, the antimicrobial resistance and pathogenic mechanisms of M. hominis isolated from extra-urogenital cystic abscess is largely unknown.

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Prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) has compromised antimicrobial efficacy against severe infections worldwide. To monitor global spread, we conducted a comprehensive genomic epidemiologic study comparing sequences from 21 bla-carrying CRKP isolates from China with K. pneumoniae sequence type (ST) 15 strains from 68 countries available in GenBank.

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Lung cancer remains the leading cause of cancer deaths worldwide and is the most common cancer in males. Immune-checkpoint inhibitors (ICIs) that target programmed cell death protein-1 (PD-1) or programmed cell death-ligand 1 (PD-L1) have achieved impressive efficacy in the treatment of non-small-cell lung cancer (NSCLC) (Pardoll, 2012; Champiat et al., 2016; Gao et al.

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Colorectal cancer liver metastasis is a major risk factor of poor outcomes, necessitating proactive interventions and treatments. Cancer-associated fibroblasts (CAFs) play essential roles in metastasis, with a focus on metabolic reprogramming. However, knowledge about associations between Cancer-associated fibroblasts metabolic phenotypes and immune cell is limited.

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Background: Hepatic immune tolerance might contribute to the development of therapeutic resistance to immunotherapy. However, addressing this issue is challenging since the efficacy of immunotherapy in the context of liver metastasis (LM) remains poorly studied. Here, we aimed to establish an LM common immune feature (LMCIF) score to quantify the characteristics of LM immunotolerance across cancer types for assisting clinical disease management.

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Colistin is considered as one of the last-resort antimicrobial agents for treating multidrug-resistant bacterial infections. Multidrug-resistant has been increasingly isolated from clinical patients, which posed a great challenge for antibacterial treatment. This study aimed to report a and co-carrying clinical isolate 5549 conferred a high-level resistance against colistin.

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Article Synopsis
  • This study explores the prevalence and antibiotic resistance of certain bacteria in outpatients from Hangzhou, China, over six years (2013-2019), examining 135,263 patients.
  • The overall prevalence of these bacteria was found to be 38.1%, with females, particularly those aged 14-20, showing significantly higher rates than males.
  • Results indicate that while some antibiotics like josamycin, tetracycline, and doxycycline remain effective (<5% resistance), others, such as ofloxacin and ciprofloxacin, have high resistance rates (>70%).
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Elucidating the mechanism for high metastasis capacity of triple negative breast cancers (TNBC) is crucial to improve treatment outcomes of TNBC. We have recently reported that nicotinamide N-methyltransferase (NNMT) is overexpressed in breast cancer, especially in TNBC, and predicts poor survival of patients undergoing chemotherapy. Here, we aimed to determine the function and mechanism of NNMT on metastasis of TNBC.

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Background: The purpose of this study was to analyze the application of individual factors, blood cell related indicators, and blood donation frequency in predicting the risk of iron deficiency of plateletpheresis donors.

Methods: A total of 801 plateletpheresis donors were included in this study. The relationship between risk factors and iron deficiency was retrospectively analyzed by univariate analysis and logistic regression analysis.

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Background: Breast cancer (BC) is the most commonly diagnosed cancer. Currently, mammography and breast ultrasonography are the main clinical screening methods for BC. Our study aimed to reveal the specific metabolic profiles of BC patients and explore the specific metabolic signatures in human plasma for BC diagnosis.

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The activity of two new fluoroquinolones, delafloxacin and finafloxacin, were evaluated against and spp. The MICs of delafloxacin, finafloxacin, and two classical fluoroquinolones (moxifloxacin and levofloxacin) were tested against 29 and 67 spp. isolates using the broth microdilution method.

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Background: N6-methyladenosine (mA) RNA methylation plays a critical role in key genetic events for various cancers; yet, how mA functions within the tumor microenvironment (TME) remains to be elucidated.

Methods: A total of 65,362 single cells from single-cell RNA-seq data derived from 33 CRC tumor samples were analyzed by nonnegative matrix factorization (NMF) for 23 mA RNA methylation regulators. CRC and Immunotherapy cohorts from public repository were used to determine the prognosis and immune response of TME clusters.

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Background: In this study, we enrolled 862 patients with Crohn's disease (CD) in China to investigate the correlation between serum vitamin D (SVD) and serum lipids, inflammatory biomarkers, and important clinical parameters.

Materials And Methods: 25(OH)D was measured by LS/MS/MS. Correlation analysis, chi-square tests, and logistic regression analysis were performed to determine the correlations between vitamin D and potential risk factors when vitamin D levels were lower than 10 ng/mL or 20 ng/mL.

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