Long-term predictions of COVID-19 waves in China based on an improved SEIRS-Q model of antibody failure.

Introduction: China had already experienced two COVID-19 epidemics since the promulgation of 10 new prevention and control measures in December 2022.

Methodology: In response to the current frequent epidemics of severe acute respiratory syndrome coronavirus 2 variants in China and the gradual relaxation of prevention and control policies, we built and ran a susceptible-exposed-infective-removed-susceptible-quarantined model incorporating self-isolation to predict future cases of COVID-19.

Results: Four waves of outbreaks were predicted to occur in November 2023, and in April, July, and November 2024.

Unveiling the drivers of vancomycin-resistant enterococcus in China: A comprehensive ecological study.

Background: Vancomycin resistant enterococci (VRE) are now considered a global public health issue. In this study, we explored the relationship between vancomycin resistance incidence and various demographic and climatic factors.

Methods: This retrospective study was performed between January 1st, 2014 and December 31st, 2021.

An MDR Salmonella Enteritidis sublineage associated with gastroenteritis outbreaks and invasive disease in China.

Objectives: Salmonella enterica serovar Enteritidis (S. Enteritidis) is a commonly reported pathogen which adapts to multiple hosts and causes critical disease burden at a global level. Here, we investigated a recently derived epidemic sublineage with multidrug resistance (MDR), which have caused extended time-period and cross-regional gastroenteritis outbreaks and even invasive nontyphoidal Salmonella disease (iNTS) in China.

The effect of molecular chaperone mediated autophagy on ApoE expression in retinal pigment epithelial cells: Molecular structure and protein action mechanism.

Chaperone mediated autophagy (CMA) represents a specialized mechanism of lysosomal protein breakdown, playing a crucial role as a metabolic pathway that helps to regulate and sustain cellular and systemic physiological equilibrium. Within the CMA process, proteins that contain sequences similar to KFERQ are specifically identified by the heat shock cognate protein 70. These proteins are then chaperoned to the lysosomes for subsequent degradation, a process facilitated by the lysosome associated membrane protein 2A.

Relationship between the morphology of the posterior pole of the eyeball and changes in choroidal structure and blood flow in myopia.

Background: The eyeball axial length (AL) is an important biological indicator of myopia, which has been widely studied. However, little research has been conducted on the relationship between eye shape and fundus structural changes in myopia. This study aimed to analyze the relationship between the shape of the posterior pole of the eye, and choroidal characteristics by comparing with the relationship between AL and choroidal characteristics.

Transgenic expression of artificial microRNA targeting soybean mosaic virus P1 gene confers virus resistance in plant.

RNA silencing is an innate immune mechanism of plants against invasion by viral pathogens. Artificial microRNA (amiRNA) can be engineered to specifically induce RNA silencing against viruses in transgenic plants and has great potential for disease control. Here, we describe the development and application of amiRNA-based technology to induce resistance to soybean mosaic virus (SMV), a plant virus with a positive-sense single-stranded RNA genome.

Analysis of pelvic floor muscle electromyography parameters in women with or without sexual dysfunction.

Background To investigate the differences in pelvic floor muscle (PFM) electromyography (EMG) parameters between women with or without sexual dysfunction (FSD) and their correlations. Methods Women who voluntarily participated in a questionnaire-based survey on sexual function and underwent PFM EMG in Weifang People's Hospital during the period from March 2021 to December 2021 were retrospectively enrolled. The female sexual (dys)function was measured using the Female Sexual Function Index.

Targeting the chromatin structural changes of antitumor immunity.

Epigenomic imbalance drives abnormal transcriptional processes, promoting the onset and progression of cancer. Although defective gene regulation generally affects carcinogenesis and tumor suppression networks, tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes, which may have significant implications for the development and application of epigenetic therapy, cancer immunotherapy, and their combinations. Herein, we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes, DNA methylation, histone post-translational modification, and chromatin structure in tumor immunogenicity, and introduce these epigenetic research methods.

Indirubin-3'-monoxime exhibits potent antiviral and anti-inflammatory effects against human adenoviruses in vitro and in vivo.

Human adenovirus (HAdV) infection is a major cause of respiratory disease, yet no antiviral drugs have been approved for its treatment. Herein, we evaluated the antiviral and anti-inflammatory effects of cyclin-dependent protein kinase (CDK) inhibitor indirubin-3'-monoxime (IM) against HAdV infection in cells and a transgenic mouse model. After evaluating its cytotoxicity, cytopathic effect reduction, antiviral replication kinetics, and viral yield reduction assays were performed to assess the anti-HAdV activity of IM.

Genomic insights and antimicrobial resistance profiles of CRKP and non-CRKP isolates in a Beijing geriatric medical center: emphasizing the carrying high-risk clones and their spread.

Background: The escalating resistance of , a prevalent pathogen in healthcare settings, especially its carbapenem-resistant (CRKP), to a wide array of antibiotics, notably β-lactams, constitutes a formidable challenge for healthcare and global public health management.

Methods: This research compared the resistance phenotypes and genomic profiles of CRKP and Non-CRKP isolates in a Beijing hospital, focusing on high-risk gene-bearing CRKP clones and the structure of mobile genetic elements facilitating their spread across hospital departments. Forty isolates were collected from various departments of the hospital and subjected to antimicrobial susceptibility testing and whole-genome sequencing to analyze their resistance phenotypes and genomic features.

A novel humanized tri-receptor transgenic mouse model of HAdV infection and pathogenesis.

Human adenovirus (HAdV) is a highly virulent respiratory pathogen that poses clinical challenges in terms of diagnostics and treatment. Currently, no effective therapeutic drugs or prophylactic vaccines are available for HAdV infections. One factor contributing to this deficiency is that existing animal models, including wild-type and single-receptor transgenic mice, are unsuitable for HAdV proliferation and pathology testing.

Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine.

Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days.

A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China.

Antimicrobial resistance of Shigella sonnei has become a global concern. Here, we report a phylogenetic group of S. sonnei with extensive drug resistance, including a combination of multidrug resistance, coresistance to ceftriaxone and azithromycin (cefazi), reduced susceptibility to fluoroquinolones, and even colistin resistance (col).

Rapid surface reconstruction strategies for oxygen evolution reactions: chemical grafting of MXene quantum dots on Ni-Co layered double hydroxides.

The surface reconstruction of transition metal-based catalysts with their specific catalytic mechanism is currently one of the hotspots and difficulties in the electrocatalytic oxygen evolution reaction (OER). Herein, a chemical grafting strategy was proposed to facilitate the surface reconstruction of Ni-Co layered double hydroxide@MXene quantum dot (Ni-Co LDH@MQDs) electrocatalysts to optimize the OER kinetics. The surface reconstruction of Ni-Co LDH@MQDs was predicted and monitored by a combination of molecular dynamics, density functional theory and experimental verification.

An outbreak of acute respiratory disease caused by HAdV-55 in Beijing, China, 2020.

Human adenoviruses (HAdVs) can cause acute respiratory diseases (ARDs) worldwide, and HAdV-55 is a reemergent pathogen in recent years. In the study, we investigated an outbreak of ARD at a school due to HAdV-55 in Beijing, China, during the early outbreak of coronavirus disease 2019 (COVID-19). The epidemic prevention team was dispatched to the school to collect epidemiologic data and nasopharyngeal samples.

Structural Modifications and Biological Activities of Natural α- and β-Cembrenediol: A Comprehensive Review.

As one of the most characteristic ingredients of glandular trichome secretions from L. (tobacco), natural cembrenediols, namely, (1,2,4,6,7,11)-2,7,11-cembratriene-4,6-diol (α-cembrenediol/α-CBD) and its C-4 epimer (β-cembrenediol/β-CBD), have attracted considerable attention for their potent antitumor, neuroprotective, antimicrobial, and other activities. Many researchers are committed to exploring the possibility of utilizing these two cembrenediols and their derivatives both in human medicine and in agricultural fungicides.

Corrigendum: A Severe Gastroenteritis Outbreak of Serovar Enteritidis Linked to Contaminated Egg Fried Rice, China, 2021.

[This corrects the article DOI: 10.3389/fmicb.2021.

Genetic Characterization of -Positive Multidrug-Resistant Serotype Typhimurium Isolated From Intestinal Infection in Children and Pork Offal in China.

With the rapid emergence of plasmid-mediated colistin resistance gene , the increased resistance of has attracted extensive attention. This study reports on 11 multidrug-resistant serovar Typhimurium strains harboring in China. They all presented resistance to colistin, and additionally, one that was isolated from a child's stool sample was also resistant to ceftriaxone and azithromycin.

A Severe Gastroenteritis Outbreak of Serovar Enteritidis Linked to Contaminated Egg Fried Rice, China, 2021.

contamination of eggs and egg shells has been identified as a public health problem worldwide. Here, we reported an outbreak of severe gastrointestinal symptoms caused by serovar Enteritidis (. enteritidis) in China.

Pneumonia Patients Caused by Co-infection With SARS-CoV-2 and Human Adenovirus in China.

To data, no patients with obvious epidemiological relationship co-infected with SARS-CoV-2 and other pathogens have been reported. Here, we investigated 10 patients caused by co-infection with SARS-CoV-2 and human adenovirus (HAdV), resulting in third-generation transmission. From Jan 15, 2020, we enrolled 10 patients with pneumonia in Hunan Province, China.

Source-tracking of the Chinese Chikungunya viruses suggests that Indian subcontinent and Southeast Asia act as major hubs for the recent global spread of Chikungunya virus.

Background: Chikungunya fever, caused by the Chikungunya virus (CHIKV), has become a major global health concern, causing unexpected large outbreaks in Africa, Asia, Europe, and the Americas. CHIKV is not indigenous to China, and its origin in the country is poorly understood. In particular, there is limited understanding of the recent global spread of CHIKV in the context of the CHIKV epidemic.