Publications by authors named "Xinyi Zhu"

The effective and precise processing of visual information by the human eye primarily relies on the diverse contrasting functions achieved through synaptic regulation of ion transport in the retina. Developing a bio-inspired retina that uses ions as information carriers can more accurately replicate retina's natural signal processing capabilities, enabling high-performance machine vision. Herein, an ion-confined transport strategy is proposed to construct a bio-inspired retina by developing artificial synapses with inhibitory and excitatory contrasting functions.

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Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years. This review firstly discusses the mechanism of molecular hydrogen of alleviating oxidative stress. Considering the current antioxidant demand in clinical dental treatment, we summarize the progress and future potential of hydrogen's application in periodontitis.

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Neuromorphic devices are designed to replicate the energy-efficient information processing advantages found in biological neural networks by emulating the working mechanisms of neurons and synapses. However, most existing neuromorphic devices focus primarily on functionally mimicking biological synapses, with insufficient emphasis on ion transport mechanisms. This limitation makes it challenging to achieve the complexity and connectivity inherent in biological systems, such as ephaptic coupling.

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Achieving both low solid content and printability for cellulose nanofiber inks remains challenging. In this study, mild hydroxyl-yne click chemistry was used to chemically crosslink dipropiolate ester of polyethylene glycol (DA-PEG) with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) oxidized cellulose nanofibers (TOCN), forming TOCN-PEG (TP) inks. This crosslinking network allowed for effective viscosity control, with TP ink viscosity increasing by 128.

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Background: Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family. It has been reported that HPK1 negatively regulates the activation of T cells. Several compounds have been developed and tested in clinical trials to target HPK1 for cancer immunotherapy.

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Background: Intraflagellar transport 80 (IFT80) is vital for primary cilia which can sense and transduce mechanical signals. Mechanical stimuli expedite osteoblastic differentiation and bone formation in mesenchymal stem cells (MSCs). However, how IFT80 regulates mechanical transduction in MSCs remains unclear.

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In this paper, we present a method for measuring weak light pulses using a single-photon detector, with a focus on detecting non-synchronized repetitive pulsed light. The proposed approach, based on interval distribution counting, enables accurate reconstruction of both the repetition rate and phase of weak pulses, facilitating the determination of the average photon number and pulse width. Specifically, the error in reconstructing the repetition rate is below ±0.

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This study evaluates the developmental and cardiotoxic effects of cyhalofop-butyl, a commonly used herbicide in rice agriculture, on zebrafish (Danio rerio) embryos. Despite its widespread application, the risk assessment of cyhalofop-butyl for aquatic organisms, especially fish, is still lacking. Focusing on the cardiac system, we used a zebrafish model to evaluate developmental abnormalities, changes in cardiac morphology and function, markers of oxidative stress, and altered gene expression.

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In living organisms, the modulation of ion conductivity in ion channels of neuron cells enables intelligent behaviors, such as generating, transmitting, and storing neural signals. Drawing inspiration from these natural processes, researchers have fabricated ionic devices that replicate the functions of the nervous system. However, this field remains in its infancy, necessitating extensive foundational research in ionic device preparation, algorithm development, and biological interaction.

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Introduction/aims: Myasthenia Gravis (MG) is a common neuromuscular junction disorder that is primarily mediated by anti-acetylcholine receptor antibodies (AChR-Ab). However, using AChR-Ab titers to predict MG severity and improvement remains controversial. This study aims to explore the relationship between AChR-Ab titers and AChR-Ab rate of change (RR-AChR-Ab, %) and MG scores.

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Ten new resin glycosides, controlins I-X (-), were isolated from the seeds of . Their structures were established by spectroscopic analysis as well as by chemical means. Compounds were identified as glycosidic acid methyl esters, considered as artifacts generated via transesterification with MeOH from natural resin glycosides.

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Objective: Neuroendocrine cervical carcinoma (NECC) is a rare but highly aggressive tumor. The clinical management of NECC follows neuroendocrine neoplasms and cervical cancer in general. However, the diagnosis and prognosis of NECC remain dismal.

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Skin, as the first line of defence of the human body, is exposed to dangers such as overheating substances, ultraviolet rays, and environmental pollutants, and the incidence of skin diseases is increasing annually. Oxidative stress plays a dominant role in most skin diseases. Abelmoschus manihot (L.

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The intestinal microbiota is a key environmental factor in the development of colorectal cancer (CRC). Here, we report that, in the context of mild colonic inflammation, the microbiota protects against colorectal tumorigenesis in mice. This protection is achieved by microbial suppression of the long non-coding RNA (lncRNA) Snhg9.

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This study investigated the protective effects and Pb-excretion mechanisms of yeast glucans (YG) with varying oxidation degrees in Pb-exposed mice. Results demonstrated that all three glucans effectively reduced blood lead levels, alleviated inflammation, and mitigated liver damage in Pb-exposed mice, with highly oxidized yeast glucan (OYG2) exhibiting the greatest efficacy. Furthermore, the glucans attenuated Pb-induced oxidative stress and pathological changes in the kidney by elevating glutathione and superoxide dismutase levels, thereby restoring renal excretory function (blood urea nitrogen and creatinine).

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Defect engineering in SrTiO crystals plays a pivotal role in achieving efficient overall solar water splitting, as evidenced by the influence of Al ions. However, the uneven structural relaxation caused by Al ions has been overlooked, significantly affecting the defect state and catalytic activity. When an AlO crucible is used, optimizing this defect engineering presents a significant challenge.

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Background: The NOD-like receptor protein (NLRP)3 inflammasome is at the signaling hub center to instigate inflammation in response to pathogen infection or oxidative stress, and its tight control is pivotal for immune defense against infection while avoiding parallel intensive inflammatory tissue injury. Acetylation of NLRP3 is critical for the full activation of NLRP3 inflammasome, while the precise regulation of the acetylation and deacetylation circuit of NLRP3 protein remained to be fully understood.

Methods: The interaction between histone deacetylase 10 (HDAC10) and NLRP3 was detected by immunoprecipitation and western blot in the HDAC10 and NLRP3 overexpressing cells.

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The resistance of pathogenic bacteria to various clinical antibiotics is the major problem in treating bacterial keratitis. Dimethyl fumarate (DMF) has good anti-fungal and anti-inflammatory effects in fungal keratitis, but its effect on bacterial keratitis is unclear. This study aims to investigate DMF's anti-inflammatory and antibacterial effects.

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Extracellular vesicles (EVs) have demonstrated considerable potential in the treatment of ischemic bone diseases, such as glucocorticoid-induced osteonecrosis of the femoral head (GIONFH). However, the clinical application of EVs faces challenges such as low yield, poor bioactivity, and lack of targeting. Herein, we have developed a platform of multiengineered extracellular vesicle mimetics (EVMs) to address these challenges.

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Article Synopsis
  • - The study investigates the challenges in diagnosing primary mediastinal large B-cell lymphoma (PMBL) due to its similarities with other lymphomas and low incidence, using data from 51 PMBL cases and 375 diffuse large B-cell lymphoma (DLBCL-NOS) instances.
  • - Results show that RHOF expression is significantly higher in PMBL compared to DLBCL-NOS, indicating that RHOF is a better diagnostic marker than traditional markers like CD23 and CD30, with ROC curve analysis supporting its usefulness.
  • - High levels of RHOF are also linked to poorer overall and progression-free survival in PMBL patients, suggesting that RHOF has potential for improving diagnosis and prognosis in clinical settings.
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  • * Results show that emotional warmth from parents is positively linked to students’ well-being, while rejection and overprotection have negative effects.
  • * Self-concept and emotional intelligence play a significant role as mediators in the relationship between parenting styles and students' subjective well-being, indicating that these factors can enhance or hinder well-being based on parental behavior.
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Schizophrenia is a mental disorder characterized by cognitive impairments, specifically deficits in social recognition memory (SRM). Abnormal hippocampal neurogenesis has been implicated in these deficits. Due to the pathogenetic heterogeneity of schizophrenia, studying the hippocampal neurogenesis and SRM in two models with prenatal and postnatal defects could enhance our understanding of the developmental aspects of the biological susceptibility to schizophrenia.

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Background: Previous research has indicated that engagement in social activities has proven advantageous for diminishing the likelihood of cognitive decline. However, no study has examined whether such cognitive benefits were to a similar extent for the young-old, the old-old, and the oldest-old groups. The purpose of this research was to determine whether aging would have an impact on the changes in cognitive function that would occur in older adults with varying degrees of social involvement.

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Article Synopsis
  • Subarachnoid hemorrhage (SAH) is a serious condition that can lead to early brain injury and is linked to high mortality rates, with neuronal ferroptosis playing a critical role in these outcomes.
  • Researchers created nanoparticles coated with hyaluronic acid to deliver ursolic acid specifically to the affected brain areas in a mouse model of SAH, analyzing how effective this treatment is at improving neurological function.
  • The study found that these nanoparticles not only targeted the injury site effectively but also helped reduce ferroptosis in neurons, potentially enhancing recovery through the activation of specific cellular signaling pathways.
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Article Synopsis
  • Aging is associated with a decline in associative memory, but older adults can still retrieve gist memory under specific conditions.
  • This study used a context reinstatement approach to see if older adults could recall specific memory when prompted with links between objects and background scenes during a recognition task.
  • Findings showed that older adults had better object recognition with reinstated backgrounds and displayed distinct brain activity patterns, suggesting they can involuntarily recall specific associations despite age-related memory challenges.
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