Sarcopenic obesity and the risk of atrial fibrillation in non-diabetic older adults: A prospective cohort study.

Background: Evidence of an association between sarcopenic obesity (SO) and the risk of long-term atrial fibrillation (AF) is lacking, and the underlying involvement of insulin resistance (IR) and inflammation is not clear.

Methods: This community-based prospective cohort study evaluated sarcopenia, obesity, and baseline clinical characteristics in 4321 non-diabetic older adults between 2007 and 2011. Sarcopenia was identified using skeletal muscle mass/body weight (SMM/BW), appendicular lean mass (ALM)/BW, and handgrip strength (HGS), and obesity was identified by fat mass (FM)/BW.

Inhibition of IP3 (Inositol 1,4,5-Trisphosphate) Receptors Retards SARS-CoV-2-Induced Endothelial von Willebrand Factor Secretion and Thrombosis.

Patients with coronavirus disease 2019 (COVID-19) are at high risk of developing a hypercoagulable state and thrombosis. The von Willebrand factor (vWF) produced by endothelial cells (ECs) is a critical thrombosis regulator. We previously found that cytoskeleton-associated protein 4 (CKAP4) is a novel receptor for the spike protein of severe acute respiratory syndrome coronavirus-2 and is involved in COVID-19-associated coagulopathy.

A novel mode of WRKY1 regulating PR1-mediated immune balance to defend against powdery mildew in apple.

Powdery mildew (PM), caused by the biotrophic fungus Podospharea leucotricha, poses a significant threat to apple production. Salicylic acid (SA) signaling plays a crucial role in enhancing resistance to biotrophic pathogens. While PR1, a defense protein induced by SA, is essential for plant immunity, its excessive accumulation can be detrimental.

Study on SARS-CoV-2 infection in middle-aged and elderly population infected with hepatitis virus: a cohort study in a rural area of northeast China.

Background: To investigate the symptoms, the level of antibody, the progression of liver disease after SARS-CoV-2 infection in middle-aged and elderly population infected with hepatitis virus.

Methods: The study was based on a cohort of high-risk liver cancer and the participants was recruited in April 2023. Blood sample were collected and information was obtained through questionnaires.

RGS1 can serve as a long-term prognostic marker in gastric cancer by promoting the infiltration and polarization of macrophages.

Gastric cancer (GC) remains a prevalent and aggressive malignancy worldwide, characterized by significant morbidity and mortality. The regulator of G-protein signaling 1 (RGS1) plays an oncogenic role in various cancers, including GC, but its clinical relevance and mechanisms remain underexplored. In this pilot study, we investigated RGS1 expression in GC tissues and its potential as a prognostic marker, laying the groundwork for future research.

Multicentre, multitime, multidimension, prospective follow-up cohort study on patients during the first wave of COVID-19 in China: a study protocol.

Introduction: During the first wave of the COVID-19 outbreak in China, the surge of COVID-19 cases was rapid and drastic. Emerging evidence suggests that beyond the acute phase, patients with COVID-19 may experience a wide range of postacute or long COVID sequelae. However, the mechanism and burden of COVID-19, especially long COVID, have not yet been comprehensively clarified.

Highly Antibacterial and Antifungal Cotton Fabric for Effective Odor Adsorption and Durable Waterproofing.

The demand for antibacterial, antifungal, and deodorant textiles has grown significantly with the increasing concern for health and hygiene. In this study, novel functional cotton fabric (EE) with long-lasting antibacterial, antifungal, and deodorant activity was prepared by graft modification with triclosan and eugenol. EE shows more than 99% antibacterial and antifungal activity against , , , and through mechanisms such as inhibiting enzyme activity and disrupting cell structure.

Injectable biomimetic hydrogel based on modified chitosan and silk fibroin with decellularized cartilage extracellular matrix for cartilage repair and regeneration.

Cartilage defect repair remains a challenge for clinicians due to the limited self-healing capabilities of cartilage. Microenvironment-specific biomimetic hydrogels have shown great potential in cartilage regeneration because of their excellent biological properties. In this study, a hydrogel system consisting of p-hydroxybenzene propanoic acid-modified chitosan (PC), silk fibroin (SF) and decellularized cartilage extracellular matrix (DCM) was prepared.

Risk and correlates of prolonged grief disorder in bereaved Chinese university students.

Bereavement can present significant challenges for university students, yet the proportion at risk of prolonged grief disorder (PGD) remains unclear. This study examined the proportion at risk of PGD and associated factors among Chinese university students. Using an online survey administered to bereaved university students in mainland China ( = 948), 424 students (=21.

Akkermansia muciniphila Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via PI3K/Akt Pathway.

Acetaminophen induced acute liver injury (ALI) has a high incidence and is a serious medical problem, but there is a lack of effective treatment. The enterohepatic axis is one of the targets of recent attention due to its important role in liver diseases. Disulfiram (DSF) is a multitarget drug that has been proven to play a role in a variety of liver diseases and can affect intestinal flora, but whether it can alleviate ALI is not clear.

A unified framework for cell-type-specific eQTL prioritization by integrating bulk and scRNA-seq data.

Genome-wide association studies (GWASs) have identified numerous genetic variants associated with complex traits, yet the biological interpretation remains challenging, especially for variants in non-coding regions. Expression quantitative trait locus (eQTL) studies have linked these variations to gene expression, aiding in identifying genes involved in disease mechanisms. Traditional eQTL analyses using bulk RNA sequencing (bulk RNA-seq) provide tissue-level insights but suffer from signal loss and distortion due to unaddressed cellular heterogeneity.

Effective denitrification from landfill leachate using magnetic PVA/CMC/DE carrier immobilized microorganisms.

Ammonia nitrogen (NH-N) discharge has caused eutrophication of water bodies and harm to humans and organisms. In this work, polyvinyl alcohol (PVA), sodium carboxymethyl cellulose (CMC), diatomite (DE), and FeO were used to prepare magnetic immobilized carriers by encapsulating microorganisms for the treatment of NH-N wastewater. The response surface methodology was used to explore the optimal ratio of the immobilized carriers.

Low shear stress induces vascular endothelial cells apoptosis via miR-330 /SOD2 /HSP70 signaling pathway.

Atherosclerosis (AS) is a chronic disease initiated by vascular endothelial dysfunction, with low shear stress (SS) being a critical inducing factor in this dysfunction. Apoptosis, a form of programmed cell death, is closely associated with AS progression. However, the impact of low SS on endothelial apoptosis and its specific molecular mechanisms remains unclear.

Simultaneously improving tabletability and solubility of diclofenac by cocrystallization with picolinamide.

Diclofenac (DIC) is a nonsteroidal anti-inflammatory drug with poor tabletability and water solubility. In the present study, a new diclofenac-picolinamide cocrystal (DIC-PIC) was prepared to simultaneously improve its tabletability and solubility. The cocrystal was characterized using multiple techniques, such as X-ray diffraction, thermal methods and spectral analyses.

Obesity modifies the association between abnormal glucose metabolism and atrial fibrillation in older adults: a community-based longitudinal and prospective cohort study.

Objective: To investigate the modifying role of obesity in the association between abnormal glucose metabolism and atrial fibrillation (AF) risk in older individuals.

Methods: From April 2007 to November 2011, 11,663 participants aged ≥60 years were enrolled in the Shandong area. Glucose metabolic status was determined using fasting plasma glucose and hemoglobin A1c levels, and obesity was determined using body mass index (BMI), waist-to-hip ratio (WHR), and visceral fat area (VFA).

Effects of wetland disturbance on methane emissions and influential factors: A global meta-analysis of field studies.

Wetlands, one of the largest source of methane (CH) on Earth, are undergoing extensive disturbance globally, resulting in profound impacts on global changes. This study conducted a comprehensive global meta-analysis of field studies to assess the effects of wetland disturbance on CH emissions and the key factors influencing these changes. Our analysis indicates that while CH emissions generally decrease following wetland disturbance, the global warming potential does not necessarily diminish compared to that of natural wetlands.

Integrative pan-cancer analysis and experiment validation identified GLS as a biomarker in tumor progression, prognosis, immune microenvironment, and immunotherapy.

Glutaminase (GLS), a crucial gene regulating glutaminolysis, has received much attention as it was found to regulate tumor metabolism and copper-induced cell death. However, its biological roles and mechanisms in human cancers remain obscure. Consequently, the integrated pan-cancer analyses and biological experiments were conducted to elucidate its oncological functions.

Exploratory review on the effect of on signaling pathways.

Background: Bunge [Fabaceae; ] (AM), a traditional Chinese medicinal (TCM) botanical drug, has been used for centuries and is gaining growing recognition in medical research for its therapeutic potential. The currently accepted scientific name is Astragalus mongholicus Bunge, with Astragalus membranaceus Fisch. ex Bunge recognized as a taxonomic synonym.

Mechanistic insight of fungal-microalgal pellets in photobioreactor for heavy-metal wastewater bioremediation.

The high cost of harvesting microalgae limits their industrial application. Fungal-microalgal pellets can efficiently harvest microalgae and enhance heavy-metal adsorption. However, the molecular response mechanism of fungal-microalgal pellets under heavy-metal stress remains unclear.

Patterns and relationships of prolonged grief, post-traumatic stress, and depressive symptoms in Chinese shidu parents: Latent profile and network analyses.

Parents who experience the trauma of losing an only child are called "shidu" parents in China. There are individual differences in post-loss outcomes.1,061 Chinese shidu parents were asked to complete questionnaires assessing prolonged grief, post-traumatic stress, and depressive symptoms.

Stimulus-responsive magnetic enzyme-encapsulated coordination polymer for the potential field monitoring of alkaline phosphatase using personal glucometer.

Alkaline phosphatase (ALP) is an enzyme that can hydrolyze phosphate groups, and its activity is related to algal bloom outbreaks in eutrophic waters. A magnetic ALP-responsive material named FeO@INV/Zn-AMP was synthesized at room temperature by using zinc ions and adenosine monophosphate (AMP) as building blocks integrated invertase (INV). When ALP is present, it hydrolyzes the phosphate group of AMP, causing the disassembly of the FeO@INV/Zn-AMP material and the release of signaling molecule (INV).

Association of Dietary Vitamin C Intake with the Risk of Metabolic Syndrome Among Adults: NHANES 2007-2018.

There has been discussion over the association between vitamin C intake and the risk of metabolic syndrome (MetS). This study examined the relationship between dietary vitamin C intake and the risk of MetS in a sizable adult American population. We examined the relationship between dietary vitamin C intake and the risk of MetS in 12,943 persons from the 2007 to 2018 National Health and Nutrition Examination Survey (NHANES).

Dietary strategies and nutritional supplements in the management of heart failure: a systematic review.

Background And Objective: Heart failure (HF) is a syndrome of increased intracardiac pressure or decreased cardiac output. There is a lack of conclusive evidence to recommend the regular use of any dietary supplement in patients with HF. However, certain studies have shown nutritional interventions to be beneficial for patients with HF.