Publications by authors named "Xinyi Wan"

Electrolyzing CO into ethylene (CH) is a promising strategy for CO utilization and carbon neutrality since CH is an important industrial feedstock. However, selectively converting CO into CH the CO electro-reduction reaction (CO ERR) is still a great challenge. Herein, Cu-CuO nanoparticles anchored on reduced graphene oxide nanosheets (Cu-CuO/rGO) were prepared from copper hydroxide nanostrands (CHNs) and graphene oxide (GO) nanosheets electrochemical reduction.

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MAT2B works together with MAT2A to synthesize S-Adenosyl methionine (SAM) as the primary methyl donor. MAT2B, despite lacking catalytic activity, exerts regulatory control over the enzymatic activity of MAT2A. In addition to the enzymatic activity regulation, we find that, in an NADP-dependent manner, MAT2B binds and stabilizes MAT2A.

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Allogeneic chimeric antigen receptor (CAR)-T cells hold great promise for expanding the accessibility of CAR-T therapy, whereas the risks of allograft rejection have hampered its application. Here, we genetically engineered healthy-donor-derived, CD19-targeting CAR-T cells using CRISPR-Cas9 to address the issue of immune rejection and treated one patient with refractory immune-mediated necrotizing myopathy and two patients with diffuse cutaneous systemic sclerosis with these cells. This study was registered at ClinicalTrials.

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Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft-tissue tumors prevalent in neurofibromatosis type 1 (NF1) patients, posing a significant risk of metastasis and recurrence. Current magnetic resonance imaging (MRI) imaging lacks decisiveness in distinguishing benign peripheral nerve sheath tumors (BPNSTs) and MPNSTs, necessitating invasive biopsies. This study aims to develop a radiomics model using quantitative imaging features and machine learning to distinguish MPNSTs from BPNSTs.

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Background: Food allergies are a growing concern worldwide, with soy proteins being important allergens that are widely used in various food products. This study investigated the potential of transglutaminase (TGase) and lactic acid bacteria (LAB) treatments to modify the allergenicity and structural properties of soy protein isolate (SPI), aiming to develop safer soy-based food products.

Results: Treatment with TGase, LAB or their combination significantly reduced the antibody reactivity of β-conglycinin and the immunoglobulin E (IgE) binding capacity of soy protein, indicating a decrease in allergenicity.

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Article Synopsis
  • The study aims to develop a model that combines radiomics, clinical risk factors, and machine learning algorithms to predict lymph node metastasis in esophageal squamous cell carcinoma.
  • The researchers analyzed data from 361 patients, extracting 1024 radiomics features and employing multiple algorithms to create various predictive models, ultimately finding the KNN model to be the best performer.
  • The combined model, which integrates both radiomics and clinical data, showed high predictive accuracy (AUC of 0.97 in training and 0.86 in testing), suggesting it can effectively guide personalized treatment strategies.
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Electrochromic smart windows have attracted great attention due to their dynamic regulation of the solar spectrum. NiO and MnO are typical anodic coloration materials and widely investigated as complementary electrodes with WO. However, NiO and MnO films often cannot be bleached to complete transparency, resulting in low transmittances and low optical modulations in the short-wavelength visible region.

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Brown carbon (BrC) is one of the important light absorption substances that have high light absorption ability under short wavelength light. However, limit studies have focused on the BrC emission from ships. In this study, size-segregated particulate matters (PM) were collected from three different types of ships, light absorption characteristics and size distribution of methanol-soluble BrC and water-soluble BrC in PM from ship exhausts were investigated.

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Complex organisms generate differential gene expression through the same set of DNA sequences in distinct cells. The communication between chromatin and RNA regulates cellular behavior in tissues. However, little is known about how chromatin, especially histone modifications, regulates RNA polyadenylation.

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Tn5 transposon tagments double-stranded DNA and RNA/DNA hybrids to generate nucleic acids that are ready to be amplified for high-throughput sequencing. The nucleic acid substrates for the Tn5 transposon must be explored to increase the applications of Tn5. Here, we found that the Tn5 transposon can transpose oligos into the 5' end of single-stranded DNA longer than 140 nucleotides.

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The distinguishing feature of a quantum system is interference arising from the wave mechanical nature of particles which is clearly central to macroscopic electronic properties. Here, we report the signature of quantum interference effect in inter-layer transport process. Via systematic magneto-drag experiments on graphene-based electronic double-layer systems, we observe low-field correction to the Coulomb-scattering-dominated inter-layer drag resistance in a wide range of temperature and carrier density, with its characteristics sensitive to the band topology of graphene layers.

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An acetic acid mediated regioselective [3 + 3] cycloaddition of substituted cyclopropane-1,1-dicarbonitriles with in situ generated mercaptoacetaldehyde was developed for the synthesis of highly stereoselective tetrahydrothiopyranols. This transformation created two new bonds in a single operation for generating complexity in tetrahydrothiopyrans. This method is characterized by cheap and readily available starting materials, simple operation, and mild reaction conditions.

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Histone marks, carriers of epigenetic information, regulate gene expression. In mammalian cells, H3K36me3 is mainly catalyzed by SETD2 at gene body regions. Here, we find that in addition to gene body regions, H3K36me3 is enriched at promoters in primary cells.

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In type II CRISPR systems, the guide RNA (gRNA) comprises a CRISPR RNA (crRNA) and a hybridized trans-acting CRISPR RNA (tracrRNA), both being essential in guided DNA targeting functions. Although tracrRNAs are diverse in sequence and structure across type II CRISPR systems, the programmability of crRNA-tracrRNA hybridization for Cas9 is not fully understood. Here, we reveal the programmability of crRNA-tracrRNA hybridization for Streptococcus pyogenes Cas9, and in doing so, redefine the capabilities of Cas9 proteins and the sources of crRNAs, providing new biosensing applications for type II CRISPR systems.

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Amid the burgeoning environmental concerns, electrochemical energy storage is of great demand, inspiring the rapid development of electrolytes. Quasi-liquid solid electrolytes (QLSEs) demonstrate exciting properties that combine high ionic conductivity and safety. Herein, a QLSE system is constructed by confining ionic liquids (ILs) into 2D materials-based membranes, which creates a subtle platform for the investigation of the nanoconfined ion transport process.

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A Yb(OTf)-mediated annulation of cyclopropane-1,1-dicarbonitriles and 2-aminobenzaldehydes for the synthesis of polysubstituted quinolines in generally good yields was investigated. In the cascade reaction, the protocol includes ring opening, intermolecular nuclophilic addition, intramolecular nuclophilic addition, and demalononitrile aromatization, in which the malononitrile group serves as a deciduous directing group mediated by Yb(OTf).

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Separation and purification of surfactant-stabilized oil-in-water nanoemulsions is a great environmental challenge. Membrane-based separation strategies are more effective over conventional methods in the treatment of nanoemulsion waste water. In this paper, we construct a superhydrophilic membrane by coating a thin photothermal-responsive iron tetrakis(4-carboxyphenyl)porphyrin (Fe-TCPP) nanofibrous metal organic framework (MOF) selective layer on a macroporous polyethersulfone membrane.

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Piperidine-mediated [3 + 3] cyclization of 2-amino-4-chromen-4-ones and substituted 2-benzylidenemalononitriles was developed for the synthesis of 2-amino-4-aryl-5-chromeno[2,3-]pyridin-5-one derivatives. This novel transformation provides a highly efficient and facile route to functionalized 5-chromeno[2,3-]pyridines from readily available substrates under mild reaction conditions.

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Synthetic biology offers new tools and capabilities of engineering cells with desired functions for example as new biosensing platforms leveraging engineered microbes. In the last two decades, bacterial cells have been programmed to sense and respond to various input cues for versatile purposes including environmental monitoring, disease diagnosis and adaptive biomanufacturing. Despite demonstrated proof-of-concept success in the laboratory, the real-world applications of microbial sensors have been restricted due to certain technical and societal limitations.

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Though evaporation-driven electricity generation has emerged as a novel eco-friendly energy and attracted intense interests, it is typically demonstrated in pure water or a very low salt concentration. Integrating evaporation-driven electricity generation and solar steam desalination simultaneously should be more promising. Herein, a polyaniline coated metal-organic frameworks (MOFs) nanorod arrays membrane is synthesized which inherits the merits of both polyaniline and MOFs, demonstrating nice stability, good interfacial solar steam desalination, and evaporation-driven electricity generation.

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Versatile tools for gene expression regulation are vital for engineering gene networks of increasing scales and complexity with bespoke responses. Here, we investigate and repurpose a ubiquitous, indirect gene regulation mechanism from nature, which uses decoy protein-binding DNA sites, named DNA sponge, to modulate target gene expression in Escherichia coli. We show that synthetic DNA sponges can be designed to reshape the response profiles of gene circuits, lending multifaceted tuning capacities including reducing basal leakage by >20-fold, increasing system output amplitude by >130-fold and dynamic range by >70-fold, and mitigating host growth inhibition by >20%.

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Periodontitis is a bacterial infectious disease leading to the loss of periodontal supporting tissues and teeth. The current guided tissue regeneration (GTR) membranes for periodontitis treatments cannot effectively promote tissue regeneration for the limited antibacterial properties and the excessively fast degradation rate. Besides, they need extra tailoring according to variform defects before implantation, leading to imprecise match.

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Hybrid heterogeneous solid acid catalysts polyoxometalate-decorated metal organic framework (POM@MOFs) thin films were synthesized from POMs and metal hydroxide nanostrands via a self-confinement method at room temperature, which show high hydrolyzing activity (1027.5 μmol g min) for ethyl acetate with durable stability and an easy recovery. This provides a general way to easily prepare nano POM@MOF thin film catalysts.

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The growing population of peri-implant diseases (PIDs) has become a public obsession, mainly due to the lack of antibacterial ability and osteogenic promotion of titanium (Ti) implants. Herein, inspired by tremella, we reported zinc oxide (ZnO)@collagen type I (Col-I)-decorated Ti for PIDs treatments. Compared with pure Ti implants, ZnO@Col-I-decorated Ti could be activated by a safe visible yellow light and showed excellent broad-spectrum antibacterial properties.

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