Publications by authors named "Xinyi Su"
Background: eHealth has enormous potential to support the self-management of depressive symptoms in people living with HIV. However, a lack of personalization is an important barrier to user engagement with eHealth. According to goal-directed design, personalized eHealth requires the identification of user personas before concrete design to understand the goals and needs of different users.
View Article and Find Full Text PDFObjectives: To determine the association between telomere length (TL) and age-related macular degeneration (AMD) and examine the potential variations with sex and ethnicity.
Methods: Population-based, cross-sectional study. A total of 52,083 participants from the UK Biobank were included.
[Absorption mechanism of iron oxide nanoparticles in Caco-2 cell model].
Wei Sheng Yan Jiu
November 2024
Objective: To explore the possible mechanism of absorption of iron oxide nanoparticles into the human body through the gastrointestinal tract.
Methods: This article used Caco-2 monolayer cells as a cell model, prepared characterized iron oxide nanoparticles(Fe_2O_3 NPs) as suspensions, and intervened in Caco-2 cells. CCK-8 method, transwell method, and atomic spectrophotometer method were used to explore the effect of Fe_2O_3 NPs on the activity of Caco-2 cells and the absorption and transport of them through the Caco-2 monolayer cell model.
Purpose: To assess the clinical and genetic characteristics of patients with Bietti crystalline dystrophy (BCD) with a focus on potential of microperimetry in monitoring macular function.
Methods: A total of 208 genetically-confirmed BCD patients were enrolled in this retrospective study. The patients were categorized into subgroups based on their fundus characteristics (fovea sparing and fovea involved), optical coherence tomography (OCT) findings (presence/absence of retinal pigment epithelium [RPE] or ellipsoid zone [EZ] line at the fovea/parafovea), and genetic profiles (Mis/Mis, Tru/Mis, Tru/Tru).
Advances in retinal pigment epithelial cell transplantation for retinal degenerative diseases.
Stem Cell Res Ther
October 2024
Article Synopsis
- * RPE transplantation is a promising cell therapy that aims to restore vision, and recent clinical trials have focused on different approaches, such as scaffold-free methods and various biomaterial scaffolds for RPE cell delivery.
- * The review discusses critical factors for successful RPE implantation, including preparation methods, delivery systems, and the importance of ensuring integration and compatibility of the grafts, while also noting ongoing research to improve these techniques.
Article Synopsis
- This study investigated how applying Zoledronic Acid (ZA) with a collagen sponge affects the healing of tooth extraction sites in rabbits over 4, 8, and 12 weeks.
- Results showed that the ZA group had significantly higher bone density compared to the group that only received the collagen sponge, especially at 8 and 12 weeks.
- While there was no noticeable difference in ridge height and width between the two groups, the ZA group showed a higher volume of collagen and fewer indicators of bone resorption, suggesting better quality of the new bone formed.
Article Synopsis
- A study in Hunan, China analyzed the late diagnosis (LD) of HIV among 22,504 people living with HIV (PLWH) from 2018 to 2021, finding that 66.6% of cases were diagnosed late.
- Older individuals (50 and above) had a higher rate of late diagnosis (71.2%), with specific factors like male gender, Han ethnicity, and regional registration linked to increased LD risk.
- In younger PLWH, additional factors such as low education level, non-student status, and being divorced or widowed contributed to LD risk, highlighting the need for targeted interventions to address these disparities, particularly for older populations.
Practice Patterns and Challenges in Managing Inherited Retinal Diseases Across Asia-Pacific: A Survey from the APIED Network.
Asia Pac J Ophthalmol (Phila)
October 2024
Article Synopsis
- The paper looks at how inherited retinal diseases (IRD) are diagnosed and treated in the Asia-Pacific region.
- They surveyed 36 centers about their practices, including how they collect patient information and provide help for low vision.
- The results showed there are important gaps, like many centers not having a database for patients, not enough genetic counselors, and a need for better support for low-vision rehabilitation.
Article Synopsis
- * Results from 21 studies with 822 participants showed that RAGT significantly improved scores in lower limb motor function, walking ability, balance, and endurance in stroke patients.
- * For optimal improvement in lower limb function, the study suggests training should be 40-60 minutes per session, 2-5 times per week, over a duration of 8-12 weeks.
Introductin: Improper gait patterns, impaired balance and foot drop consistently plague stroke survivors, preventing them from walking independently and safely. Neuromuscular electrical stimulation (NMES) technology can help patients reactivate their muscles and regain motor coordination. This study aims to systematically review and summarize the evidence for the potential benefits of NMES on the improvement of gait patterns after stroke.
View Article and Find Full Text PDFArticle Synopsis
- iPSC technology has enabled the creation of cellular models for inherited retinal diseases (IRDs), which aim to understand disease processes for better treatment options.
- There is a need for consistency and quality control in developing these models, as standard metrics are not yet commonly implemented.
- The review outlines a toolkit for generating effective iPSC-derived models and discusses key factors, scientific challenges, and future prospects in this research area.
Article Synopsis
- - Excess hydrogen peroxide produced during retinal cell metabolism can cause oxidative damage to retinal pigment epithelium (RPE), contributing to blindness, but dietary antioxidants can help prevent this problem.
- - The study tested the potential protective effects of lutein against oxidative stress in ARPE-19 cell models exposed to hydrogen peroxide on specially designed 3D scaffolds.
- - Results showed that lutein pretreatment reduced oxidative stress, preserved cell functions, and decreased inflammatory cytokines, indicating that lutein could be beneficial for eye health in oxidative stress conditions.
Article Synopsis
- Temperature-responsive hydrogels, known as thermogels, are effective for delivering both small drugs and larger biological therapeutics, with properties influenced by the polymer's hydrophilic-hydrophobic balance and molecular characteristics.
- A new study focused on enhancing hydrogen bonding by creating amphiphilic polymers with urea linkages, leading to improved hydration and better gel properties, such as phase transition temperature and stiffness.
- Results indicated that these urea linkages significantly changed the drug release profile of Aflibercept, showcasing the potential to optimize drug delivery outcomes by adjusting hydrogen bonding in polymer structures.
Article Synopsis
- A new sensor design enables the in situ detection of solid-state biomarkers found on human skin, providing significant health insights while avoiding issues related to accessing biofluids like sweat.
- The technology utilizes an ionic-electronic bilayer hydrogel that allows for the effective dissolution, diffusion, and electrochemical analysis of both water-soluble and water-insoluble solid-state analytes, achieving ultra-sensitive detection limits.
- Clinical studies show that these stretchable wearable sensors accurately correlate solid-state epidermal biomarkers with blood markers and physiological activities, paving the way for convenient and non-invasive biomarker monitoring.
Article Synopsis
- The study aimed to examine how oral exposure to iron oxide nanoparticles (Fe₂O₃NPs) affects male rat reproduction.
- Forty rats were divided into control and three dose groups, receiving different amounts of Fe₂O₃NPs for 28 days, with measures taken on body weight, reproductive organ weights, and sperm analysis.
- Results showed significant disorganization in sperm production and increased sperm deformities in higher dose groups, but no major changes in overall body weight or certain enzyme activities were observed.
Article Synopsis
- * The impacts of this absorption not only hinder the quality of tobacco but also increase health risks from smoking, necessitating proactive measures to reduce heavy metal uptake.
- * This paper aims to address the lack of comprehensive reviews on control strategies by evaluating the effects of heavy metals on tobacco and health, and exploring various methods such as chemical immobilization and agronomic adjustments that can help lower heavy metal content in tobacco plants.
Article Synopsis
- Reducing immunogenicity is crucial for the success of the biobetter Erbitux (CMAB009), as immune responses can decrease treatment effectiveness and cause side effects.
- A competitive ligand binding (CLB) assay was developed for CMAB009, focusing on high drug and target tolerance through innovative methods that minimize interference during testing.
- The validated NAb assay achieved impressive sensitivity and tolerances, making it a reliable tool for assessing neutralizing antibodies and potentially beneficial for testing other therapeutics.
Rationale and protocol paper for the Asia Pacific Network for inherited eye diseases.
Asia Pac J Ophthalmol (Phila)
February 2024
Article Synopsis
- The Asia-Pacific region, housing about 60% of the world's population, lacks extensive knowledge about hereditary eye diseases, necessitating a regional collaboration to enhance precision medicine for affected patients.
- The Asia-Pacific Inherited Eye Disease (APIED) network, consisting of 55 members from 35 centers across 12 countries, aims to address these gaps in understanding inherited retinal diseases (IRDs) by bringing together experts in the field.
- The network's goals include improving genetic diagnosis of IRDs, standardizing phenotyping practices, and creating high-quality patient registries to support care and research in both regional and international contexts.*
Article Synopsis
- - This letter responds to comments on the effects of pesticide use in fruits and vegetables on eye health, highlighting the risks involved with eye exposure to pesticides.
- - Pesticides can directly affect the eyes, with harmful effects resulting from their absorption into eye tissues.
- - Although organic diets might reduce pesticide exposure, the original studies mentioned do not clearly indicate whether organic diets were actually part of the interventions; more systematic reviews are needed to compare organic and nonorganic diets.
: Oxidative stress is a key risk factor for visual impairment and consuming dietary antioxidant-rich foods may help in managing visual impairments. However, a limited number of studies have investigated the effect of dietary antioxidant-rich food including grapes on eye health in older adults. : To assess the effects on macular pigment accumulation of regular consumption of grapes in Singapore older adults.
View Article and Find Full Text PDFExploration of adaptation process and experience among the HIV/AIDS patients based on the comprehensive task-based adaptation model.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
June 2023
Article Synopsis
- The study investigates how HIV/AIDS patients adapt to their condition, focusing on the emotional and practical challenges they face during this process.
- Researchers conducted in-depth interviews with 43 patients and identified 6 major themes, highlighting the complexity of their adaptation, symbolized by the phrase "the shadow comes along with the sunshine."
- The findings suggest that interventions should consider the unique and shared aspects of adaptation tasks to improve the adjustment and overall outcomes for those living with HIV/AIDS.
Article Synopsis
- Transplanting stem cell-derived retinal pigment epithelial (RPE) cells shows promise as a treatment for age-related macular degeneration (AMD), with previous trials confirming its safety but limited effectiveness.
- A study involving the transplantation of these RPE cells into rabbits revealed that, after one month, the transplanted cells maintained their identity and began to mature toward a state similar to adult human RPE.
- The research suggests that specific transcription factors are activated in the transplanted RPE cells, which helps them adapt to the new environment and may support the function of surrounding photoreceptor cells, providing valuable insights for future AMD treatments.
Present day strategies for delivery of wireless photodynamic therapy (PDT) to deep-seated targets are limited by the inadequacy of irradiance and insufficient therapeutic depth. Here we report the design and preclinical validation of a flexible wireless upconversion nanoparticle (UCNP) implant (SIRIUS) that is capable of large field, high intensity illumination for PDT of deep-seated tumors. The implant achieves this by incorporating submicrometer core-shell-shell NaYF UCNPs into its design, which significantly enhances upconversion efficiency and mitigates light loss from surface quenching.
View Article and Find Full Text PDFRetinal pigment epithelial (RPE) cell dysfunction is a key driving force of AMD. RPE cells form a metabolic interface between photoreceptors and choriocapillaris, performing essential functions for retinal homeostasis. Through their multiple functions, RPE cells are constantly exposed to oxidative stress, which leads to the accumulation of damaged proteins, lipids, nucleic acids, and cellular organelles, including mitochondria.
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