Characterization, antioxidant activity and stability of cattle bone collagen peptides‑selenium chelate.

In this study, cattle bone collagen peptides-selenium chelate (CCP-Se) was prepared and its structure, oxidation resistance and stability were characterized. The selenium binding capacity was 33.65 ± 0.

Effect of prognostic nutritional index on laboratory parameters and survival in metastatic colorectal cancer patients treated with fruquintinib: a retrospective study.

Objective: Fruquintinib, a novel anti-angiogenic targeted drug, has gained widespread application in the treatment of metastatic colorectal cancer. This study aims to investigate the impact of the prognostic nutritional index (PNI) on the safety and survival outcomes of patients undergoing fruquintinib treatment for metastatic colorectal cancer.

Methods: A cohort of 106 patients with metastatic colorectal cancer, treated with fruquintinib at Zhejiang Cancer Hospital between 2019 and 2023, was included in this study.

Clathrin-Mediated Endocytosis of Multiple Nanoparticles Tends to Be Less Cooperative: A Computational Study.

The internalization of nanoparticles is of great significance for their biological applications. Clathrin-mediated endocytosis (CME) is one of the main endocytic pathways. However, there is still a lack of a fundamental understanding regarding the internalization of multiple nanoparticles via CME.

Conversion of monocropping to intercropping promotes rhizosphere microbiome functionality and soil nitrogen cycling.

Intercropping can increase soil nutrient availability and provide greater crop yields for intensive agroecosystems. Despite its multiple benefits, how intercropping influences rhizosphere microbiome assemblages, functionality, and complex soil nitrogen cycling is not fully understood. Here, a three-year field experiment was carried out on different cropping system with five fertilization treatments at the main soybean production regions.

Efficacy of endometrial receptivity testing for recurrent implantation failure in patients with euploid embryo transfers: study protocol for a randomized controlled trial.

Background: Embryo implantation remains a critical barrier in assisted reproductive technologies. One of the main causes of unsuccessful embryo implantation is window of implantation (WOI) displacement, particularly in patients with recurrent implantation failure (RIF). Therefore, a reliable diagnostic tool for identifying the optimal WOI is essential.

A lateral flow immunoassay method for the rapid detection of acetochlor and alachlor in vegetable oil by sensitivity enhancement by using dimethyl-β-cyclodextrin.

Acetochlor is an endocrine disruptor. The acetochlor residue is strongly lipophilic and can be enriched into products during the manufacturing process. In this study, we found that dimethyl-β-cyclodextrin (DM-β-CD) solution could decrease the apparent oil/water partition coefficient () of acetochlor and increase the sensitivity of fluorescence lateral flow immunoassay (LFIA) for acetochlor simultaneously.

Potential roles of enteric glial cells in Crohn's disease: A critical review.

Enteric glial cells in the enteric nervous system are critical for the regulation of gastrointestinal homeostasis. Increasing evidence suggests two-way communication between enteric glial cells and both enteric neurons and immune cells. These interactions may be important in the pathogenesis of Crohn's disease (CD), a chronic relapsing disease characterized by a dysregulated immune response.

SPP1 as a risk factor for patients with acute on chronic liver failure undergoing liver transplantation.

Background: Acute on chronic liver failure (ACLF) is characterized by systemic inflammation and significant mortality, calling for accurate assessment due to the diverse prognosis of liver transplantation (LT).

Methods: 8 patients with ACLF and 4 normal controls (NC) underwent peripheral blood mononuclear cells (PBMCs) transcriptomics, whereas 9 patients with ACLF and 3 NC had hepatic CD45 T cells transcriptomics. Thecandidateindicatorfoundinthetranscriptomicswas confirmedbya retrospective cohort (n = 137) and one prospective cohort (n = 68).

Fertilizing-induced alterations of microbial functional profiles in soil nitrogen cycling closely associate with crop yield.

Fertilization and rhizosphere selection are key regulators for soil nitrogen (N) cycling and microbiome. Thus, clarifying how the overall N cycling processes and soil microbiome respond to these factors is a prerequisite for understanding the consequences of high inputs of fertilizers, enhancing crop yields, and formulating reasonable nitrogen management strategies under agricultural intensification scenarios. To do this, we applied shotgun metagenomics sequencing to reconstruct N cycling pathways on the basis of abundance and distribution of related gene families, as well as explored the microbial diversity and interaction via high throughput sequencing based on a two-decade fertilization experiment in Loess Plateau of China semiarid area.

Recent Advances in Graphitic Carbon Nitride Based Electro-Catalysts for CO Reduction Reactions.

The electrocatalytic carbon dioxide reduction reaction is an effective means of combating the greenhouse effect caused by massive carbon dioxide emissions. Carbon nitride in the graphitic phase (g-CN) has excellent chemical stability and unique structural properties that allow it to be widely used in energy and materials fields. However, due to its relatively low electrical conductivity, to date, little effort has been made to summarize the application of g-CN in the electrocatalytic reduction of CO.

Computational screening of effective g-CN based single atom electrocatalysts for the selective conversion of CO.

Two-dimensional (2D) material-based single-atom catalysts (SACs) have demonstrated their potential in electrochemical reduction reactions but exploring suitable 2D material-based SACs for the CO reduction reaction (CORR) by experiments is still a formidable task. In this study, theoretical screening of transition metal (TM)-doped graphitic carbon nitride (g-CN) materials as catalysts for the CORR was systematically performed based on density functional theory (DFT) calculations. An indicator for the selective formation of one carbon (C1) products was developed to screen catalysts that are active and selective in the CORR.

Research on the Professional Mentality of Hengdian Drifter's.

Background: Hengdian drifters refer to outsiders who participate in shooting film and television dramas in Hengdian. It is a special group. Single access to information, precarious nature of work, unequal treatment of gender, constraints on development, and inadequate guarantee mechanisms are all to blame.

TNFα-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity.

The heterogeneity and drug resistance of colorectal cancer (CRC) often lead to treatment failure. Isocitrate dehydrogenase 1 (IDH1), a rate-limiting enzyme in the tricarboxylic acid cycle, regulates the intracellular redox environment and mediates tumor cell resistance to chemotherapeutic drugs. The aim of this study was to elucidate the mechanism underlying the involvement of IDH1 acetylation in the development of CRC drug resistance under induction of TNFα.

A time-resolved fluorescence lateral flow immunochromatographic assay based on oriented immobilized antibodies for the ultrasensitive detection of C-peptides in human serum.

C-peptide is a biomarker that has clinical implications for the diagnosis of a variety of diseases. In this study, an ultrasensitive time-resolved fluorescence lateral flow immunochromatographic assay (TRF-LFIA) method was established for the detection of C-peptides in human serum. The key to this method is the oriented immobilization of antibodies anti C-peptide on TRF microspheres that can sufficiently expose the antigen binding site.

A mix-and-detect method based on colloidal gold immunochromatographic assay for on-site detection of zearalenone in edible oils.

The common methods to detect zearalenone (ZEN) in edible oils need organic solvents to extract ZEN and then some sample purification process before detection, so, it is not convenient for on-site use. Here a simple method without organic solvents and a sample purification process was developed for the determination of ZEN in edible oils. The detection process only needs mixing oil with a surfactant solution in the indicated ratio and then loading the mixture onto a colloidal gold immunochromatographic (CGI) strip for detection.

Downward trend in the prevalence of Helicobacter pylori infections and corresponding frequent upper gastrointestinal diseases profile changes in Southeastern China between 2003 and 2012.

This present study aims to determine trends in the prevalence of H. pylori infections in Southeastern China between 2003 and 2012, and investigate corresponding changes in the prevalence of upper gastrointestinal diseases. This retrospective study screened 196,442 patients with a mean age of 47.

Anatomical predilection of intestinal metaplasia based on 78,335 endoscopic cases.

Background/aims: Gastric intestinal metaplasia (IM) is an important risk factor for intestinal-type gastric carcinoma, and successful treatment critically depends on its timely detection. In order to guide appropriate endoscopic surveillance, objective knowledge on the anatomical predilection of intestinal metaplasia development is urgently needed.

Materials And Methods: A total of 78,335 cases who underwent gastroduodenoscopy from 2008 to 2013 in Jiangsu and Anhui provinces in China, were studied.