Cryotherapy for low rectal and anal cancer: recommendation and indications.

Low rectal cancer is a common gastrointestinal malignancy. Organ preservation in the treatment of low rectal cancer is a challenge. By combining surgical resection with freezing-a complementary treatment for low rectal cancer-the anus can be preserved in some patients.

Suitable T stage for cryosurgery to spare the anus in patients with low rectal cancer.

Sphincter preserving therapy is a key research focus for treating low rectal cancer; however, the role of cryotherapy in this process has seldom been reported in the literature. Therefore, we conducted a comprehensive report on the role of cryoablation in sphincter preservation and explored its effect in rectal cancers. An observational study used longitudinal observation and follow-up.

A novel treatment approach for a patient with advanced low rectal cancer: A case report and literature review.

Rationale: In the treatment of low rectal cancer (LRC), preserving the anal sphincter is increasingly attracting the attention of colorectal surgeons. Many patients refused to perform a colostomy. Here, we report a case of LRC in a middle-aged woman and the clinical implications of the symptom, the treatment process of LRC, and the complications.

Knockdown of carboxypeptidase A4 () inhibits gastric cancer cell progression via cell cycle arrest and apoptosis.

Background: Gastric cancer is one of the most prevalent cancers, with a low survival rate at the later stages. Carboxypeptidase A4 () is associated with the aggressiveness and growth in cancer. However, its regulatory role in gastric cancer remains unknown.

Deep-Learning-Based Automatic Detection of Photovoltaic Cell Defects in Electroluminescence Images.

Photovoltaic (PV) cell defect detection has become a prominent problem in the development of the PV industry; however, the entire industry lacks effective technical means. In this paper, we propose a deep-learning-based defect detection method for photovoltaic cells, which addresses two technical challenges: (1) to propose a method for data enhancement and category weight assignment, which effectively mitigates the impact of the problem of scant data and data imbalance on model performance; (2) to propose a feature fusion method based on ResNet152-Xception. A coordinate attention (CA) mechanism is incorporated into the feature map to enhance the feature extraction capability of the existing model.

Immune Cytolytic Activity for Comprehensive Insights of the Immune Landscape in Endometrial Carcinoma.

Immune checkpoint blockade (ICB) has been explored as a therapeutic strategy to recover the antitumor immune activities against endometrial cancer (EC) escaping from immune surveillance. Increasing evidence has indicated that microsatellite instability (MSI) is a promising biomarker to stratify patients for the ICB therapy. However, even in patients with MSI-High (MSI-H) endometrial cancers, PD-L1 inhibitors, avelumab, and durvalumab have shown only 27% of response rates.

Identification of hub genes associated with prognosis, diagnosis, immune infiltration and therapeutic drug in liver cancer by integrated analysis.

Background: Liver cancer is one of the most common cancers and causes of cancer death worldwide. The objective was to elucidate novel hub genes which were benefit for diagnosis, prognosis, and targeted therapy in liver cancer via integrated analysis.

Methods: GSE84402, GSE101685, and GSE112791 were filtered from the Gene Expression Omnibus (GEO).

Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.

Adipocytes and adipocyte lipid metabolism are closely related with obesity and type 2 diabetes, but the molecular mechanism still needs further investigation. The aim of this study is to discover the adipocyte genes and pathways involved in obesity and type 2 diabetes using bioinformatics analysis. The GSE27951 gene expression profile was obtained.

Characteristics of the Microbial Community in the Production of Chinese Rice-Flavor Baijiu and Comparisons With the Microflora of Other Flavors of Baijiu.

Rice-flavor baijiu is one of the four basic flavor types of Chinese baijiu. Microbial composition plays a key role in the classification of baijiu flavor types and the formation of flavor substances. In this study, we used high-throughput sequencing technology to study the changes of microbial community in the production of rice-flavor baijiu, and compared the microbial community characteristics during production of rice-, light-, and strong-flavor baijiu.

Bioinformatic Identification of Hub Genes and Analysis of Prognostic Values in Colorectal Cancer.

The purpose of this study is to discover novel hub genes which are helpful for diagnosis, prognosis, and targeted therapy in colorectal cancer (CRC) by using bioinformatics analysis. GSE74602, GSE110225, and GSE113513 were extracted from the gene expression omnibus (GEO). Differentially expressed genes (DEGs) in expression profiles were identified by GEO2R.